Anhedonia is associated with suicidal ideation independently of depression: A meta-analysis

Ducasse, Déborah; Loas, Gwenolé; Dassa, Déborah; Gramaglia, Carla; Zeppegno, Patrizia; Guillaume, Sébastien; Olié, Émilie; Courtet, Philippe

doi:10.1002/da.22709

Cited by 176 publications

(112 citation statements)

References 60 publications

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“…Anhedonia has been found to be predictive of future suicidal thoughts, attempts, and behavior (Ballard et al, ; Spijker et al, ; Winer et al, ). A recent meta‐analysis found that anhedonia was significantly related to current suicidal ideation, even while controlling for depression and other psychiatric diagnoses (Ducasse et al, b). Though many previous accounts report the effect of high levels of chronic anhedonia, our recent research suggests that it is acute anhedonia, rather than chronic, that is prospectively predictive of suicide (Hawes et al, ).…”

Section: Suicide Crisis Syndromementioning

confidence: 99%

Suicide Crisis Syndrome: A review of supporting evidence for a new suicide‐specific diagnosis

Schuck

Calati

Barzilay

et al. 2019

Behavioral Sci & The Law

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Suicide is a major public health problem, and suicide rates are still on the rise. Current strategies for identifying individuals at risk for suicide, such as the use of a patient's self‐reported suicidal ideation or evidence of past suicide attempts, have not been sufficient in reducing suicide rates. Recently, research groups have been focused on determining the acute mental state preceding a suicide attempt. The development of an acute suicidal diagnosis, the Suicide Crisis Syndrome (SCS), is aimed at capturing this state to better treat individuals. The SCS has five main evidence‐based components—entrapment, affective disturbance, loss of cognitive control, hyperarousal, and social withdrawal. The SCS may provide clinicians with the ability to identify individuals who are experiencing an acute pre‐suicidal mental state, regardless of their self‐reported suicidal ideation. Future research leading to the incorporation of this diagnosis into clinical practice could improve the quality of care and reduce the personal, societal, and legal burden of suicide.

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Section: Suicide Crisis Syndromementioning

confidence: 99%

Suicide Crisis Syndrome: A review of supporting evidence for a new suicide‐specific diagnosis

Schuck

Calati

Barzilay

et al. 2019

Behavioral Sci & The Law

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“…Consistent with prior studies, higher State‐A was associated with greater depressive symptoms, whereas trait anticipatory and consummatory anhedonia both were not significantly associated with depression (Gard et al, ; Loas et al, ). Some studies found that State‐A (recent changes and acuity) was especially predictive of suicidal ideation independently of depressive symptoms (Ducasse et al, ; Hawes et al, ; Winer et al, ; Winer et al, ). Other studies found that State‐A mediated the positive association between depressive symptoms/perceived burdensomeness/thwarted belongingness and suicidality (Loas et al, ; Zielinski et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Anhedonia, defined as a lowered ability to experience pleasure, has been identified as a suicide risk factor (Loas, ). Recent works suggested taking into account the severity and the type of anhedonia when examining suicidal ideation (SI) (Ducasse et al, ; Loas et al, ). Anhedonia has been defined as both a state and a trait, dependent on whether it is thought of as an aspect of a depressive state or a personality trait (Loas & Pierson, ).…”

mentioning

confidence: 99%

“…Anhedonia has been defined as both a state and a trait, dependent on whether it is thought of as an aspect of a depressive state or a personality trait (Loas & Pierson, ). Several studies have reported a high level of state anhedonia to be associated with a high risk of suicide (Ducasse et al, ; Winer et al, ; Winer et al, ), while a high level of trait anhedonia has been found to be unrelated or negatively associated with suicide (Loas, ; Loas et al, ). Recently, trait anticipatory and trait consummatory anhedonia have been clearly defined as two separate components with distinct neural networks (Treadway & Zald, ).…”

mentioning

confidence: 99%

“…Although state anhedonia has a significant direct effect on SI (Ducasse et al, ; Hawes et al, ), little research has been conducted on indirect influences on state and trait anhedonia such as potential moderators. A dynamic relationship may exist between internal anhedonia and external stress.…”

mentioning

confidence: 99%

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Stress and Suicidal Ideation: The Role of State or Trait Anhedonia in a Moderated Mediation Model

Yang

Wang

Liu

et al. 2019

Suicide & Life Threat Behav

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Background Recent works suggested taking into account the severity and the type of anhedonia when examining suicidal ideation. The present study investigated a moderated mediation model addressing the psychosocial mechanisms that account for the association between state or trait anhedonia and suicidal ideation. Methods State anhedonia was assessed using the Snaith‐Hamilton Pleasure Scale, while trait anhedonia was assessed using the Temporal Experience of Pleasure Scale. A total number of 1,361 of undergraduates completed questionnaires at three different times, with one‐year intervals. Results The direct effect of stress on suicidal ideation was significantly greater for those students who had lower trait anticipatory and consummatory anhedonia, whereas the indirect effect from stress on suicidal ideation through depression was significantly greater for those who had higher state anhedonia. Moreover, trait consummatory anhedonia moderated the relationship between stress and suicidal ideation after one year, and trait anticipatory anhedonia moderated the relationship between stress and suicidal ideation after two years. Conclusions Low levels of trait anhedonia were associated with elevated suicidal ideation, while high levels of state anhedonia were associated with elevated suicidal ideation. Trait consummatory anhedonia was associated with short‐term suicidal ideation, while trait anticipatory anhedonia was associated with long‐term suicidal ideation.

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Modulation of habenular and nucleus accumbens functional connectivity by ketamine in major depression

Taraku,

Loureiro,

Sahib

et al. 2024

Brain and Behavior

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IntroductionMajor depressive disorder (MDD) is associated with dysfunctional reward processing, which involves functional circuitry of the habenula (Hb) and nucleus accumbens (NAc). Since ketamine elicits rapid antidepressant and antianhedonic effects in MDD, this study sought to investigate how serial ketamine infusion (SKI) treatment modulates static and dynamic functional connectivity (FC) in Hb and NAc functional networks.MethodsMDD participants (n = 58, mean age = 40.7 years, female = 28) received four ketamine infusions (0.5 mg/kg) 2−3 times weekly. Resting‐state functional magnetic resonance imaging (fMRI) scans and clinical assessments were collected at baseline and 24 h post‐SKI. Static FC (sFC) and dynamic FC variability (dFCv) were calculated from left and right Hb and NAc seeds to all other brain regions. Changes in FC pre‐to‐post SKI, and correlations with changes with mood and anhedonia were examined. Comparisons of FC between patients and healthy controls (HC) at baseline (n = 55, mean age = 32.6, female = 31), and between HC assessed twice (n = 16) were conducted as follow‐up analyses.ResultsFollowing SKI, significant increases in left Hb‐bilateral visual cortex FC, decreases in left Hb‐left inferior parietal cortex FC, and decreases in left NAc‐right cerebellum FC occurred. Decreased dFCv between left Hb and right precuneus and visual cortex, and decreased dFCv between right NAc and right visual cortex both significantly correlated with improvements in mood ratings. Decreased FC between left Hb and bilateral visual/parietal cortices as well as increased FC between left NAc and right visual/parietal cortices both significantly correlated with improvements in anhedonia. No differences were observed between HC at baseline or over time.ConclusionSubanesthetic ketamine modulates functional pathways linking the Hb and NAc with visual, parietal, and cerebellar regions in MDD. Overlapping effects between Hb and NAc functional systems were associated with ketamine's therapeutic response.

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Anhedonia is associated with suicidal ideation independently of depression: A meta-analysis

Cited by 176 publications

References 60 publications

Suicide Crisis Syndrome: A review of supporting evidence for a new suicide‐specific diagnosis

Suicide Crisis Syndrome: A review of supporting evidence for a new suicide‐specific diagnosis

Stress and Suicidal Ideation: The Role of State or Trait Anhedonia in a Moderated Mediation Model

Modulation of habenular and nucleus accumbens functional connectivity by ketamine in major depression

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