Anhedonia in Depression and Bipolar Disorder

Whitton, Alexis E.; Pizzagalli, Diego A.

doi:10.1007/7854_2022_323

Cited by 16 publications

(11 citation statements)

References 84 publications

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“…20 It originates from the Greek language, where “an” means without and “hedeone” means pleasure. 21 Originally, anhedonia was referred to as the total loss of pleasure, both physical and psychic. Currently, according to the fifth edition of The Diagnostic and Statistical Manual of Mental Disorders (DSM-V), anhedonia is defined as a lack of enjoyment from, engagement in, or energy for life’s experiences as well as deficits in the capacity to feel pleasure and take interest in things.…”

Section: Discussionmentioning

confidence: 99%

“…Anhedonia is a common symptom of major depressive disorder. 10 , 21 , 22 Having a personal history of depression, bipolar disorder, alcoholism, and other mental disorders is considered a risk factor for anhedonia. Anhedonia has also been treated as a trait or a state.…”

Section: Discussionmentioning

confidence: 99%

“… 22 It has been suggested that severe and/or chronic illness, like cancer, chronic pain, or heart disease, may influence the appearance of anhedonia. 21 , 23–27 Anhedonia was also demonstrated to be more common in females with polycystic ovary syndrome (PCOS) 28 PCOS Polish patients showed pronounced features of type D personality (higher scores for distress, anxiety and depression). 29 As PCOS is associated with acne 30 it was of importance that all our female patients did not present with any signs of polycystic ovary syndrome.…”

Section: Discussionmentioning

confidence: 99%

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Anhedonia in Acne Vulgaris: A Cross-Sectional Study of 104 Consecutive Acne Patients

Szepietowska,

Stefaniak,

Krajewski

et al. 2024

CCID

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Background Anhedonia is defined as a reduced ability to experience or even a total loss of pleasure. Purpose This study was undertaken to evaluate anhedonia in 104 consecutive acne patients. Material and Methods Acne severity was assessed with Investigator Global Assessment (IGA), anhedonia was studied with the Snaith-Hamilton Pleasure Scale (SHAPS), Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS) and Temporal Experience of Pleasure Scale (TEPS). Moreover, the quality of life (QoL) and stigmatization, as well as depression and anxiety (Hospital Anxiety and Depression Scale – HADS), were additionally evaluated. Results Anhedonia was found in 20.19% of acne patients and was more common (p=0.007) in males (34.29%) than in females (13.04%). Based on SHAPS, males with acne showed significantly (p=0.049) higher levels of anhedonia (2.39 ± 3.18 points) than acne females (1.26 ± 2.36 points). Anhedonia significantly correlated with the clinical acne severity (SHAPS: r=0.205, p=0.038 and ACIPS: r=−0.222, p=0.026). Although the intensity of anhedonia did not show any relationship with QoL and stigmatization assessments, there was a significant correlation between anhedonia and depressive symptoms (SHAPS: r=0.310, p<0.001; ACIPS: r=−0.364, p<0.001). Such dependency was not documented for anxiety. Conclusion Anhedonia seems to be a common phenomenon in acne and should be considered in the holistic approach to acne patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Anhedonia in Acne Vulgaris: A Cross-Sectional Study of 104 Consecutive Acne Patients

Szepietowska,

Stefaniak,

Krajewski

et al. 2024

CCID

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“…Recent advances in the eld of fMRI have revealed compelling evidence suggesting that individuals in good health exhibit substantial activation in striatal regions (namely, the NAc, caudate, and putamen) while undergoing reward processing. Conversely, individuals experiencing anhedonia often exhibit diminished activity in these striatal regions whether with MDD or not [32][33][34][35] .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of real versus sham DLPFC-NAc rTMS for depressed adolescents with anhedonia using resting-state functional magnetic resonance imaging (fMRI): a study protocol for a randomized placebo-controlled trial

Lv,

Cai,

Tang

et al. 2023

Preprint

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Introduction Anhedonia is considered one of the core symptoms of major depressive disorder (MDD), which predicts adverse outcomes among adolescents, including illness severity, antidepressant refractoriness, recurrence of MDD and suicide. Patients who suffer from anhedonia have a faint response to selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioral therapy (CBT). Previous research has indicated associations between anhedonia and abnormalities within the reward circuitry, highlighting the potential of the nucleus accumbens (NAc) as a viable target. Considering deep location of the NAc, repetitive transcranial magnetic stimulation (rTMS) has potential to modulate this specific region. Recent methodological advances suggest that treatment technology has significant potential in precisely targeting the left dorsolateral prefrontal cortex (DLPFC) and modulating the functional connectivity (FC) between DLPFC and NAc for adolescent patients with anhedonia. We will conduct a study to explore the safety and effectiveness of using resting-state fcMRI-guided rTMS for treating anhedonia in adolescents diagnosed with MDD. Methods and analysis This article presents a study protocol for a randomized, double-blind, placebo-controlled, parallel-group experiment. A quantity of 88 patients will be recruited and randomly assigned to receive either active rTMS or sham rTMS. The primary outcome is to determine the percentage change in the severity of anhedonia, as assessed through the Snaith-Hamilton Pleasure Scale (SHAPS), from the beginning to the end of the follow-up period (from baseline to 8 weeks after treatment). Secondary outcome measures will include fMRI measurements, Hamilton rating scale for depression (HAMD-17), Montgomery Asberg depression rating scale (MADRS), Chinese version of temporal experience of pleasure scale (CV-TEPS), Chinese version of Beck scale for suicide ideation (BSI-CV), clinical global impression (CGI) and monitoring adverse events. Assessments will be conducted at baseline, as well as at 1, 2, 4, and 8 weeks. Ethics and dissemination The study protocol received approval from the ethics committee of Xijing Hospital in September 2022 (Protocol ID: KY20222165-F-1). The study findings will be published in peer-reviewed journals. Trial registration number ClinicalTrials.gov, NCT05544071

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“…Anhedonia is present in approximately 70-95% of depressed individuals, with notable variations in severity (Dichter, 2010;Whitton & Pizzagalli, 2022). Recent research has focused on anhedonia rather than depression with symptoms of anhedonia, revealing the detrimental effects on mental health (Ducasse et al, 2018) in both clinical and nonclinical samples (Heininga et al, 2019;Pizzagalli et al, 2005).…”

Section: Anhedoniamentioning

confidence: 99%

Anhedonia and Daily Emotional Experiences Among Mothers of Preschool Children: An Experiential Sampling Study

Takamatsu

2024

Preprint

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Positive emotions induced by child cuteness are critical components of the human parenting system. However, anhedonia, which is characterized by reduced subjective experiences of pleasure, may undermine parenting experiences by reducing responses to child cuteness. Using the experiential sampling method, the current research examined associations among parental anhedonia, responses to child cuteness, and daily parenting experiences. Eighty-two mothers of preschool children participated in the 5-day survey and reported momentary positive and negative emotions and parental experiences. They also completed an end-of-day survey in which they rated the interaction quality with their child and perceived fatigue. The results showed that compared to the control, mothers with high anhedonia reported dampened cuteness in child and elevated negative emotions (anxiety and frustration). In addition, they were more likely to report their child’s mood more negative relative to the control. At the end of day, the high anhedonia group reported lower interaction quality. Self-rated fatigue did not differ among groups. These results suggest that anhedonia undermines parenting experiences by diminishing cuteness-induced positive emotions while amplifying negative emotions.

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Anhedonia in Depression and Bipolar Disorder

Cited by 16 publications

References 84 publications

Anhedonia in Acne Vulgaris: A Cross-Sectional Study of 104 Consecutive Acne Patients

Anhedonia in Acne Vulgaris: A Cross-Sectional Study of 104 Consecutive Acne Patients

Efficacy of real versus sham DLPFC-NAc rTMS for depressed adolescents with anhedonia using resting-state functional magnetic resonance imaging (fMRI): a study protocol for a randomized placebo-controlled trial

Anhedonia and Daily Emotional Experiences Among Mothers of Preschool Children: An Experiential Sampling Study

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