Anhedonia and Abstinence as Predictors of the Subjective Pleasantness of Positive, Negative, and Smoking-Related Pictures

Guillot, Casey R.; Halliday, Teresa M; Kirkpatrick, Matthew G.; Pang, Raina D.; Leventhal, Adam M.

doi:10.1093/ntr/ntx036

Cited by 48 publications

(6 citation statements)

References 50 publications

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“…This suggests that the altered ratings of pleasant and unpleasant images was accounted for by the OAT group's elevated anhedonia, and that effects on ratings of drug images may have also been partially accounted for by anhedonia. This is consistent with a previous study in people with nicotine dependence, which found that this combined pattern (blunting of subjective response to both pleasant and unpleasant images and increased ratings of drug stimuli) was related to anhedonia 19 . However this contrasts with Gerra et al 's 10 finding that abstinent participants with heroin dependence rated unpleasant images as more unpleasant than controls.…”

Section: Discussionsupporting

confidence: 93%

“…However, previous studies that reported associations between OUD and P3 responses during pleasant images did not report matching participants according to tobacco use. In light of reports of altered responses to pleasant stimuli in tobacco smokers 19,20 , this may be a critical difference in the present study, and points to the importance of considering the role of nicotine when examining altered responses to affective stimuli in substance use disorder populations.…”

Section: Discussionmentioning

confidence: 76%

“…Finally, studies comparing OUD and control groups often do not match groups on other variables that could be associated with affective and attentional responses, or fail to report whether groups are matched. For example, tobacco use is associated with blunted neural and subjective responses to pleasant stimuli in some studies 19,20 . High rates of tobacco use among people with OUD could therefore confound studies where control groups are not matched according to tobacco use.…”

Section: Introductionmentioning

confidence: 99%

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Startle-elicited Event-Related Potentials to Affective Stimuli are Associated with Recent Illicit Opioid use among Patients Receiving Opioid Agonist Treatment

et al. 2021

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Opioid use disorder (OUD) has been linked to exaggerated attentional, affective, and arousal responses to opioid-related stimuli, as well as altered responses to other affective (eg, naturally rewarding or aversive) stimuli, particularly blunted responses to pleasant/rewarding stimuli. Both exaggerated responses to drug-related stimuli and reduced response to pleasant stimuli may influence the course of OUD and its treatment, however interpretation of studies thus far is limited by methodological issues. In the present study, we examined subjective ratings, and attenuation of the P3 component of the acoustic startle-evoked event-related potential (as a measure of attention), while viewing neutral, pleasant, unpleasant, and drug-related images. Participants prescribed opioid agonist treatment (OAT) for OUD (n = 82) were compared to a carefully-matched control group (n = 33) and to recently-abstinent participants with OUD (n = 22). Relative to controls, participants prescribed OAT gave higher positive valence ratings of drug images, and blunted valence responses to other affective images, but groups did not differ in terms of arousal ratings or P3 amplitude. Within the OAT group, linear modeling of associations between frequency of recent illicit opioid use and startle P3 amplitude found an association between increased recent illicit opioid use and reduced attention to pleasant, relative to unpleasant, images. The latter finding may have implications for interventions targeting cognitive biases in people with substance use disorder. In particular, they suggest that enhancing attention to pleasant stimuli may be as, if not more important, than the typical approach of trying to reduce attentional bias to drug-related stimuli.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

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Startle-elicited Event-Related Potentials to Affective Stimuli are Associated with Recent Illicit Opioid use among Patients Receiving Opioid Agonist Treatment

et al. 2021

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“…Few studies ( n = 4) used behavioral tasks. Guillot et al used the Picture Rating Task, which is a measure of affective valence related to positive, negative, and smoking cues (27). In this task, participants were instructed to rate the pleasantness of each stimulus by pressing keys corresponding to seven-point Likert scale from −3 (very unpleasant) to 3 (very pleasant).…”

Section: Resultsmentioning

confidence: 99%

Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review

et al. 2019

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Background: Recently, anhedonia has been recognized as an important Research Domain Criterion (RDoC) by the National Institute of Mental Health. Anhedonia is proposed to play an essential role in the pathogenies of both addictive and mood disorders, and possibly their co-occurrence with a single individual. However, up to now, comprehensive information about anhedonia concerning its underlying neurobiological circuitries, the neurocognitive correlates, and their role in addiction, mood disorder, and comorbidity remains scarce. Aim: In this literature review of human studies, we bring together the current state of knowledge with respect to anhedonia in its relationship with disorders in the use of substances (DUS) and the comorbidity with mood disorders. Method: A PubMed search was conducted using the following search terms: (Anhedonia OR Reward Deficiency) AND ((Drug Dependence OR Abuse) OR Alcohol OR Nicotine OR Addiction OR Gambling OR (Internet Gaming)). Thirty-two articles were included in the review. Results: Anhedonia is associated with substance use disorders, and their severity is especially prominent in DUS with comorbid depression. Anhedonia may be both a trait and a state dimension in its relation to DUS and tends to impact DUS treatment outcome negatively.

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“…In summary, the Cook study was by far the most rigorous study and it found a significant effect of abstinence that was related to inability to stop smoking. This, plus the several other positive results 29 Self-selected reward ratings (none) Cook et al 41 Ratings of rewards (20%) Ratings of lab stimuli Guillot et al 44 Ratings of positive pictures (none) Anhedonia scales Hughes et al 40 AES (6%) REI enjoyment (5%) TEPS (none) TEPS (6%) Lawn et al 27 Ratings of rewards (none) SHAPS (150%) Powell et al 43 SHAPS (71%) 28 Music (18%) Money (none) Perkins et al 42 Music (49%) Perkins et al 37 Music (22%) Video (31%) Money (none) Perkins et al 38 Music (21%) Video (25%) Rewards' influence on responding Kalamboka et al 45 Experiment 1 Money (none) Powell 43 Money (15%) Choosing more frequent/larger rewards Audrain-McGovern et al 29 Money (none) Hughes et al 40 Money (none) Money (none) Pergadia et al 30 Money (98%)…”

Section: Self-reportsmentioning

confidence: 92%

Possible New Symptoms of Tobacco Withdrawal II: Anhedonia—A Systematic Review

Hughes

Klemperer

Peasley-Miklus

2018

Nicotine &Amp; Tobacco Research

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Introduction When animals undergo nicotine deprivation, rewards become less rewarding (ie, anhedonia occurs). We searched for tests of whether anhedonia occurs in abstinent smokers. Methods The major inclusion criterion was a within-participants comparison of behavioral measures of reward sensitivity or self-reported anhedonia during smoking versus during abstinence among daily smokers. A computerized search of PubMed, PsychInfo, and Cochrane databases and other methods located 13 studies. All but one were laboratory studies. Results The number of studies and participants were small and the results mixed. In terms of anticipatory anhedonia (ie, wanting a reward), abstinence appeared to decrease willingness to work for immediately available rewards, but did not appear to influence how much adding rewards to a task increased responding. Abstinence also appeared to produce small increases in self-reported anticipatory anhedonia. In terms of consummatory anhedonia (ie, liking a reward), self-report measures found anhedonia decreased pleasure from rewards in some but not all tests. In terms of learning (ie, learning to choose a more frequent reward), abstinence did not reliably decrease allocating responding to high versus low frequency reward options. Conclusions Although results were mixed, abstinence appears to increase anticipatory anhedonia. It is unclear if abstinence increases consummatory or reward learning-based anhedonia. Further studies of anhedonia in clinical settings are needed (1) to estimate the reliability and clinical significance of anhedonia as a symptom of tobacco withdrawal, (2) to assess if effects represent withdrawal versus offset processes, and (3) to assess if anhedonia interferes with the ability to stop smoking. Implications Anticipatory anhedonia appears to be a symptom of tobacco withdrawal and should be added to tobacco withdrawal checklists and diagnostic criteria. Further study of consummatory and learning-based anhedonia is warranted.

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Anhedonia and Abstinence as Predictors of the Subjective Pleasantness of Positive, Negative, and Smoking-Related Pictures

Cited by 48 publications

References 50 publications

Startle-elicited Event-Related Potentials to Affective Stimuli are Associated with Recent Illicit Opioid use among Patients Receiving Opioid Agonist Treatment

Startle-elicited Event-Related Potentials to Affective Stimuli are Associated with Recent Illicit Opioid use among Patients Receiving Opioid Agonist Treatment

Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review

Possible New Symptoms of Tobacco Withdrawal II: Anhedonia—A Systematic Review

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