Angular dose anisotropy around gold nanoparticles exposed to X-rays

Gadoue, Sherif M.; Toomeh, Dolla; Zygmanski, Piotr; Sajo, Erno

doi:10.1016/j.nano.2017.02.017

Cited by 15 publications

(8 citation statements)

References 25 publications

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“…A detailed picture of the dose about GNP a for the N a = 0 case (i.e., a GNP irradiated in the absence of neighboring particles) has been presented elsewhere in the literature . In the supplementary material (see Figs.…”

Section: Resultsmentioning

confidence: 99%

“…Energy absorption in this configuration, is particularly sensitive to lateral electron emissions. The direction of electron emission from an irradiated GNP is a complex function of the incident photon energy and is not isotropic . In the planar geometry, when Auger electrons or low energy photoelectrons are emitted along the cluster plane, their ray‐lines pass through three GNPs and therefore it is likely most of their energy will be deposited within the gold, rather than only a moderate portion of it as is the case in the HCP configuration.…”

Section: Resultsmentioning

confidence: 99%

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Dosimetric consequences of gold nanoparticle clustering during photon irradiation

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Dosimetric consequences of gold nanoparticle clustering during photon irradiation

et al. 2017

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“…When the GNP is large relative to the range of electrons generated therein, many low-energy electrons are trapped inside the GNP. Decreasing the size of the GNP, on the other hand, decreases the total number of photon interactions, leading to a reduced number of secondary electrons (Gadoue et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Different distributions of gold nanoparticles on the tumor and calculation of dose enhancement factor by Monte Carlo simulation

Keshavarz¹,

Sardari²

2019

NUCET

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Gold nanoparticles can be used to increase the dose of the tumor due to its high atomic number as well as being free from apparent toxicity. The aim of this study is to evaluate the effect of distribution of gold nanoparticles models, as well as changes in nanoparticle sizes and spectrum of radiation energy along with the effects of nanoparticle penetration into surrounding tissues in dose enhancement factor DEF. Three mathematical models were considered for distribution of gold nanoparticles in the tumor, such as 1-uniform, 2- non-uniform distribution with no penetration margin and 3- non-uniform distribution with penetration margin of 2.7 mm of gold nanoparticles. For this purpose, a cube-shaped water phantom of 50 cm size in each side and a cube with 1 cm side placed at depth of 2 cm below the upper surface of the cubic phantom as the tumor was defined, and then 3 models of nanoparticle distribution were modeled. MCNPX code was used to simulate 3 distribution models. DEF was evaluated for sizes of 20, 25, 30, 50, 70, 90 and 100 nm of gold nanoparticles, and 50, 95, 250 keV and 4 MeV photon energies. In uniform distribution model the maximum DEF was observed at 100 nm and 50 keV being equal to 2.90, in non-uniform distribution with no penetration margin, the maximum DEF was measured at 100 nm and 50 keV being 1.69, and in non-uniform distribution with penetration margin of 2.7 mm, the maximum DEF was measured at 100 nm and 50 keV as 1.38, and the results have been showed that the dose was increased by injecting nanoparticles into the tumor. It is concluded that the highest DEF could be achieved in low energy photons and larger sizes of nanoparticles. Non-uniform distribution of gold nanoparticles can increase the dose and also decrease the DEF in comparison with the uniform distribution. The non-uniform distribution of nanoparticles with penetration margin showed a lower DEF than the non-uniform distribution without any margin and uniform distribution. Meanwhile, utilization of the real X-ray spectrum brought about a smaller DEF in comparison to mono-energetic X-ray photons.

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“…CSLCs was about 1.6 that significantly was higher than parental cells. Theoretically, these findings can be explained by new nanodosimetric models (12,58,59). In the presence of GNPs, production of Auger electrons with low energy and small range results in highly inhomogenous dose distributions on the nanoscale.…”

Section: Discussionmentioning

confidence: 99%

Combination of gold nanoparticles with low-LET irradiation: an approach to enhance DNA DSB induction in HT29 colorectal cancer stem-like cells

Abbasian

Baharlouei

Arab‐Bafrani

et al. 2018

J Cancer Res Clin Oncol

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High-linear energy transfer (High LET) irradiation has significant cytotoxic effects on different cancerous, stem-like, cells (CSLCs) such as colon CSLCs. A review of the literature has indicated that the presence of gold nanoparticles (GNPs) enables low LET irradiation to produce a highly non-homogeneous dose distributions like high LET irradiation.The purpose of this study was to evaluate the radio-responsiveness of HT29 colon CSLCs under low LET irradiation (X-ray) and in the presence of GNPs.Radio-responsiveness was evaluated using the ϒ-H2AX foci formation assay, the clonogenic assay, the cell cycle progression assay and analyses of radiobiological parameters.In the presence of GNPs, the survival fraction of HT29 CSCLs was significantly reduced, and caused significant changes in the radiobiological parameters after irradiation. In addition, ϒ-H2AX assay showed that in the presence of GNPs, the persistent DNA double strand breaks (DSBs) were significantly increased in irradiated HT29 CSLCs. The relative biological effectiveness (RBE) value of GNPs with Xrays was about 1.6 for HT-29 CSLCs at the D10 stage when compared to X-rays alone. Therefore, the combination of GNPs with X-ray irradiation has potential to kill HT29 CSLCs greater than the X-rays alone, and may be considered as an alternative for high LET irradiation.

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Angular dose anisotropy around gold nanoparticles exposed to X-rays

Cited by 15 publications

References 25 publications

Dosimetric consequences of gold nanoparticle clustering during photon irradiation

Dosimetric consequences of gold nanoparticle clustering during photon irradiation

Different distributions of gold nanoparticles on the tumor and calculation of dose enhancement factor by Monte Carlo simulation

Combination of gold nanoparticles with low-LET irradiation: an approach to enhance DNA DSB induction in HT29 colorectal cancer stem-like cells

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