Angptl8 mediates food-driven resetting of hepatic circadian clock in mice

Chen, Siyu; Feng, Mengyang; Zhang, Shiyao; Dong, Zhewen; Wang, Yifan; Zhang, Wenxiang; Liu, Chang

doi:10.1038/s41467-019-11513-1

Cited by 60 publications

(45 citation statements)

References 71 publications

(79 reference statements)

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“…However, RT-qPCR results illustrated that there were strong daily fluctuations in the expression of Scd1 and Scd2. Our pervious study illustrated the circadian rhythm of Angptl8 [27]. The presented study further revealed the circadian rhythm of Angptl3 and Angptl4, which oscillated both under LD and L-DD.…”

Section: Discussionsupporting

confidence: 71%

“…The present study extended our recent publication [27], and screened the oscillation gene in mouse liver under L-DD through MetaCycle. Approximatively 12.1% of the genes exhibited 24 h oscillation under L-DD.…”

Section: Discussionmentioning

confidence: 66%

“…The composition of the murine gut microbiome, memory Function, and plasma metabolome was influenced by DD [26]. Under the DD model and fast-refeeding conditions, we have identified the Angptl8 as a hepatokine that mediates food-driven resetting of hepatic clock and diurnal rhythms of metabolic genes in mice [27]. Therefore, DD is an important factor not only for circadian clock but also for metabolism.…”

Section: Introductionmentioning

confidence: 92%

“…The raw sequencing data (FASTQ files) was aligned to the mouse genome (NCB137/mm10) using Bowtie. The RNA-seq data under 6 weeks of constant darkness (called long time dark-dark condition, L-DD) was deposited, and the GEO number is GSE133342 [27]. To compare gene oscillation pattern under normal light-dark condition (LD) and short time (2 days) dark-dark condition (S-DD), the data were retried from GEO database for LD (GSE114400, [28]) and S-DD (GSE70497, [29]).…”

Section: Transcriptome Sequencingmentioning

confidence: 99%

“…The present study was conducted in mice acclimated to DD conditions for 6 weeks (called long time darkdark condition, L-DD) to eliminate light influence. The liver samples were collected based on CT time points and subjected to RNA sequencing to profile the changes of gene expression abundance in the liver [27]. Meta-Cycle was used to screen the oscillation genes and realtime RT-qPCR was used to confirm the gene expression patterns.…”

Section: Introductionmentioning

confidence: 99%

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Endogenous circadian time genes expressions in the liver of mice under constant darkness

Zhang

et al. 2020

BMC Genomics

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Background: The circadian rhythms regulate physiological functions and metabolism. Circadian Time (CT) is a unit to quantify the rhythm of endogenous circadian clock, independent of light influence. To understand the gene expression changes throughout CT, C57BL/6 J mice were maintained under constant darkness (DD) for 6 weeks, and the liver samples were collected starting at 9:00 AM (CT1), and every 4 h in a 24-h cycle (CT5, CT9, CT13, CT17 and CT21). Total RNA was extracted and subjected to RNA-Seq data (deposited as GSE 133342, L-DD). To compare gene oscillation pattern under normal light-dark condition (LD, GSE114400) and short time (2 days) dark-dark condition (S-DD, GSE70497), these data were retried from GEO database, and the trimmed mean of M-values normalization was used to normalize the three RNA-seq data followed by MetaCycle analysis. Results: Approximate 12.1% of the genes under L-DD exhibited significant rhythmically expression. The top 5 biological processes enriched in L-DD oscillation genes were mRNA processing, aromatic compound catabolic process, mitochondrion organization, heterocycle catabolic process and cellular nitrogen compound mitotic catabolic process. The endogenous circadian rhythms of clock genes, P450 genes and lipid metabolism genes under L-DD were further compared with LD and S-DD. The oscillation patterns were similar but the period and amplitude of those oscillation genes were slightly altered. RT-qPCR confirmed the selected RNA sequence findings. Conclusions: This is the first study to profile oscillation gene expressions under L-DD. Our data indicate that clock genes, P450 genes and lipid metabolism genes expressed rhythmically under L-DD. Light was not the necessary factor for persisting circadian rhythm but influenced the period and amplitude of oscillation genes.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 92%

Section: Transcriptome Sequencingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Endogenous circadian time genes expressions in the liver of mice under constant darkness

Zhang

et al. 2020

BMC Genomics

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Coupled network of the circadian clocks: a driving force of rhythmic physiology

2020

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The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt to daily changes in their environment. In mammals, circadian clocks form a hierarchically organized network with a ‘master clock’ located in the suprachiasmatic nucleus of the hypothalamus, which ensures entrainment of subsidiary oscillators to environmental cycles. Robust rhythmicity of body clocks is indispensable for temporally coordinating organ functions, and the disruption or misalignment of circadian rhythms caused for instance by modern lifestyle is strongly associated with various widespread diseases. This review aims to provide a comprehensive overview of our current knowledge about the molecular architecture and system‐level organization of mammalian circadian oscillators. Furthermore, we discuss the regulatory roles of peripheral clocks for cell and organ physiology and their implication in the temporal coordination of metabolism in human health and disease. Finally, we summarize methods for assessing circadian rhythmicity in humans.

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Systematic Research and Evaluation Models of Nanomotors for Cancer Combined Therapy

Wan

Wang

et al. 2020

Angewandte Chemie

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Limited tumor permeability of therapeutic agents is a great challenge faced by current cancer therapy methods. Herein, a kind of near infrared light (NIR)‐driven nanomotor with autonomous movement, targeted ability, hierarchical porous structure, multi‐drugs for cancer chemo/photothermal therapy is designed, prepared and characterized. Further, we establish a method to study the interaction between nanomotors and cells, along with their tumor permeability mechanism, including 2D cellular models, 3D multicellular tumor spheroids and in vivo models. In vivo tumor elimination results verify that the movement behaviour of the nanomotors can greatly facilitate them to eliminate tumor through multiple therapeutic methods. This work tries to establish systematic research and evaluation models, providing strategies to understand the relationship between motion behaviour and tumor permeation efficiency of nanomotors in depth.

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Angptl8 mediates food-driven resetting of hepatic circadian clock in mice

Cited by 60 publications

References 71 publications

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Endogenous circadian time genes expressions in the liver of mice under constant darkness

Coupled network of the circadian clocks: a driving force of rhythmic physiology

Systematic Research and Evaluation Models of Nanomotors for Cancer Combined Therapy

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