Angle-closure: risk factors, diagnosis and treatment

Amerasinghe, Nishani; Aung, Tin

doi:10.1016/s0079-6123(08)01104-7

Cited by 68 publications

(49 citation statements)

References 55 publications

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“…Previous studies have found that women are more likely to develop angle-closure glaucoma. (21,29,30) CPACG eyes also have significantly shorter axial lengths, shallower anterior chamber depths and less myopia than POAG eyes.…”

Section: Discussionmentioning

confidence: 96%

A prospective comparison of chronic primary angle-closure glaucoma versus primary open-angle glaucoma in Singapore

Ngo¹,

Aquino²,

Shabana³

et al. 2013

smedj

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the optic disc, visual field and ocular characteristics (such as intraocular pressure [IOP] at presentation, best-corrected visual acuity, sphere equivalent, mean keratometry, axial length, lens thickness, corneal thickness and lens opacity) of a consecutive cohort of Asian patients with CPACG, and to compare them with a similarly enrolled sample of patients with POAG. METHODSThis was a prospective comparative study of new patients with POAG or CPACG, who presented to the National University Health System, a tertiary eye care centre in Singapore, from January 2002 to June 2009. These were newly diagnosed patients, with no previous treatment or laser therapy done. The patients, who presented with unrelated eye conditions, were found to have clinical signs suggestive of glaucoma. They were referred from general ophthalmology clinics and community screening programmes for diabetes mellitus and glaucoma, as they were found to have suspicious discs or raised IOP. Ethics approval was obtained from the institutional review board and the study was conducted in accordance with the Declaration of Helsinki.Written informed consent was obtained from all study participants prior to enrolment in the study. RESULTS 98 patients were enrolled (POAG n = 48; CPACG n = 50). CPACG patients were significantly older (66.5 ± 9.2 years vs. 64.1 ± 13.5 years; p = 0.027) and mostly female (p = 0.004). CPACG eyes had significantly higher intraocular pressure (26.9 ± 6.9 mmHg vs. 24.5 ± 3.3 mmHg; p = 0.03), shorter axial length (22.89 ± 0.97 mm vs. 24.26 ± 1.79 mm; p < 0.001) and shallower anterior chamber depth (2.60 ± 0.25 mm vs. 3.16 ± 0.48 mm; p < 0.001). HVF mean deviation or pattern standard deviation (PSD) did not differ significantly between POAG and CPACG eyes, but the latter had a lower PSD for a given mean deviation. HRT parameters between the two groups were not significantly different. CONCLUSIONIn this study, CPACG eyes had significantly higher presenting intraocular pressure than POAG eyes, but there were no significant differences in optic disc topography. A majority of the patients in both groups had moderate field defects at the time of presentation, followed by severe and then mild defects. The field loss in CPACG eyes was more diffuse than that in POAG eyes.

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Section: Discussionmentioning

confidence: 96%

A prospective comparison of chronic primary angle-closure glaucoma versus primary open-angle glaucoma in Singapore

Ngo¹,

Aquino²,

Shabana³

et al. 2013

smedj

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“…Pilocarpin) wird das Irisstroma dünn gestreckt und so die Penetration erleichtert. Eine Vorbehandlung mit Apraclonidin oder Brimonidin senkt die Häufigkeit von AID-Spitzen nach der Lasertherapie [3,4,5]. Dünnere Bereiche der Iris, z.B.…”

Section: Therapieoptionenunclassified

“…Die Durchgängigkeit der LPI wird mit einem Argonlaser hergestellt (Herdgröße 50 µm, Energie 600-1400 mW, Dauer 0,1 s). Anschließend wird die LPI mit dem Nd:YAG-Laser erweitert (Leistung 1,4-6 mJ) [4]. In kaukasischen Augen mit dünneren Irides kann der Nd:YAG-Laser (1-6 mJ) allein ausreichend sein, um eine LPI anzulegen [3,5].…”

Section: Therapieoptionenunclassified

Chirurgische Behandlung des Engwinkelglaukoms

Lim¹,

Aquino²,

Chew³

2018

Kompass Ophthalmol

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Fortschritte in der Bildgebung des vorderen Segments haben neue Erkenntnisse für ein besseres Verständnis der verschiedenen Mechanismen des Engwinkelglaukoms (EWG) geliefert. Diese Entwicklung ist von großer Bedeutung für eine gute Entscheidungsfindung bei Patienten mit EWG, die eine adäquate Therapie benötigen. Das chirurgische Management des EWG ist nach wie vor ein integraler Bestandteil der Patientenversorgung bei Glaukom. Die spezielle Anatomie des Auges mit Winkelverschluss und das geringe Maß an verfügbarer objektiver Evidenz für die Wirksamkeit der verschiedenen chirurgischen Behandlungsoptionen stellen Glaukomchirurgen vor Herausforderungen. Übersetzung aus Dev Ophthalmol. Basel, Karger, 2017, vol 59, pp 147-154 (DOI: 10.1159/000458493)

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“…hronic angle-closure glaucoma (CACG) is characterized by the permanent angle-closure resulting from peripheral anterior synechiae (PAS) (1) . In many eyes that have undergone one or more episodes of acute primary angle-closure (APAC), the appearance of PAS is a consequence of the transformation of the appositional closure of the angle into a permanent closure.…”

mentioning

confidence: 99%

“…Peripheral anterior synechiae may also have other causes (uveitis, ocular trauma, post operative complications of glaucoma or cataract surgery or keratoplasty etc.) (1) . Treatment of CACG remains challenging and in general, many eyes with this type of glaucoma become blind because the intraocular pressure (IOP) is extremely elevated and refractory to clinical treatment.…”

mentioning

confidence: 99%

Efficacy of goniosynechialysis in the treatment of chronic angle-closure glaucoma: a five-case report

Cronemberger¹,

Loredo²,

Faria³

et al. 2013

Rev. bras.oftalmol.

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We retrospectively analyzed the clinical data of five patients with chronic angle-closure glaucoma who underwent goniosynechialysis (GSL). RESUMOAnalisamos retrospectivamente os dados clínicos de cinco pacientes com seio camerular fechado por sinéquias anteriores periféri-cas (SAP) secundárias à crise aguda de fechamento angular primário e submetidos à goniossinequiálise (GSL). Os pacientes apresentavam fechamento sinequial circunferencial por seis meses ou menos e foram acompanhados, no mínimo, por seis meses após a GSL. Após um acompanhamento médio de 32.4±13.9 meses, a acuidade visual melhorou em quatro (80%) olhos. Antes da GSL, a pressão intraocular (Po) variou de 34 a 58 mmHg. Após a GSL, a Po variou de 8 a 44 mmHg. A Po foi normalizada pela GSL com ou sem medicação em 80% dos olhos. Antes da GSL, todos os pacientes estavam sob tratamento antiglaucomatoso máximo incluindo o uso de 250 mg de acetazolamida por via oral três vezes ao dia. Após a GSL, três pacientes não mais necessitaram de medicação antiglaucomatosa e um paciente necessitou usar apenas uma medicação tópica antiglaucomatosa. A GSL foi eficaz e segura em quatro pacientes e não foi eficaz em um paciente. Ocorre um aumento da taxa de sucesso da GSL quando ela é associada à facoemulsificação com implante de lente intraocular.

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Angle-closure: risk factors, diagnosis and treatment

Cited by 68 publications

References 55 publications

A prospective comparison of chronic primary angle-closure glaucoma versus primary open-angle glaucoma in Singapore

A prospective comparison of chronic primary angle-closure glaucoma versus primary open-angle glaucoma in Singapore

Chirurgische Behandlung des Engwinkelglaukoms

Efficacy of goniosynechialysis in the treatment of chronic angle-closure glaucoma: a five-case report

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