Angle closure glaucoma secondary to psychotropic medications

Ocular toxicity of psychotropic medications in a tertiary hospital in Lagos, Nigeria

“…Angle-closure secondary to psychotropic medications is a rare but visually threatening side effect. The mechanism by which this occurs is due to their anticholinergic effect resulting in mydriasis and forward displacement of the lens-iris diaphragm and ciliary body swelling or serotonergic effect, which results in the lens-iris diaphragm displacement and relaxation of sphincter pupillae muscle [ 12 ]. These changes can cause occlusion of the trabecular meshwork, blocking the drainage of aqueous humor with an increase in IOP in susceptible individuals.…”

“…These changes can cause occlusion of the trabecular meshwork, blocking the drainage of aqueous humor with an increase in IOP in susceptible individuals. The highest risk classes are tricyclic antidepressants (TCAs) and second-generation antipsychotics (SGAs), evident in the documented case reports [ 12 - 14 ].…”