Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma

Perdomo‐Pantoja, Alexander; Mejía-Pérez, Sonia Iliana; Reynoso-Noverón, Nancy; Gómez-Flores-Ramos, Liliana; Soto-Reyes, Ernesto; Sánchez-Correa, Thalía Estefania; Guerra-Calderas, Lissania; Castro-Hernández, Clementina; Vidal-Millán, Silvia; Sánchez‐Corona, José; Taja‐Chayeb, Lucía; Gutiérrez-Hernández, Olga; Cacho-Díaz, Bernardo; Álvarez-Gómez, Rosa María; Gómez-Amador, Juan Luis; Ostrosky‐Wegman, Patricia; Corona, Teresa; Herrera-Montalvo, Luis Alonso; Wegman-Ostrosky, Talía

doi:10.1371/journal.pone.0206590

Cited by 16 publications

(9 citation statements)

References 53 publications

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“…The expression of RAS components has been linked to the hallmarks of cancer due to an upregulation of such components in some cancer types [ 12 , 13 , 99 ]. The function of RAS has been involved in proliferative signaling, growth suppressor evasions, apoptosis resistance, angiogenesis, cellular energetics deregulation, inflammation, cellular migration, invasion and metastasis [ 100 ]. Cancer patients suffering novel coronavirus pneumonia face the risk of poor prognosis after infection due to the malignant tumor itself, chemotherapy and surgery [ 101 ].…”

Section: Ace2 Associations With Several Diseases and Covid-19mentioning

confidence: 99%

ACE2: the molecular doorway to SARS-CoV-2

López-Léon²,

et al. 2020

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The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different cell types. Some factors that can affect the expression of the ACE2 are: sex, environment, comorbidities, medications (e.g. anti-hypertensives) and its interaction with other genes of the renin-angiotensin system and other pathways. Different factors can affect the risk of infection of SARS-CoV-2 and determine the severity of the symptoms. The ACE2 enzyme is a negative regulator of RAS expressed in various organ systems. It is with immunity, inflammation, increased coagulopathy, and cardiovascular disease. In this review, we describe the genetic and molecular functions of the ACE2 receptor and its relation with the physiological and pathological conditions to better understand how this receptor is involved in the pathogenesis of COVID-19. In addition, it reviews the different comorbidities that interact with SARS-CoV-2 in which also ACE2 plays an important role. It also describes the different factors that interact with the virus that have an influence in the expression and functional activities of the receptor. The goal is to provide the reader with an understanding of the complexity and importance of this receptor.

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Section: Ace2 Associations With Several Diseases and Covid-19mentioning

confidence: 99%

ACE2: the molecular doorway to SARS-CoV-2

López-Léon²,

et al. 2020

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“…They prospectively collected blood samples prior to surgery and analyzed the DNA using Ion Torrent next-generation sequencing. Their findings suggest that an AGT rs5050 GG-genotype is associated with poor prognosis in this population, making it a potential prognostic biomarker (15).…”

Section: Molecular and Neuroimaging Biomarkers In Glioblastomamentioning

confidence: 97%

Management of glioblastoma: a perspective from Mexico

Moreno-Jiménez¹,

Alegría-Loyola²,

Sonabend³

et al. 2021

Chin Clin Oncol

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Access to healthcare in Mexico is available to its population via publicly and privately funded institutions. The public sector, administered by both the local and federal government under the jurisdiction of the Department of Health, provides healthcare to the majority of the country's population. Privately funded institutions vary in size and scope of practice, ranging from small clinics focused on family practice, to large tertiary hospitals with capacity for treating patients with complex conditions and performing clinical research. The evaluation and treatment of patients with cancer in Mexico is also available through both sectors. In the country's capital, Mexico City, patients with glioblastoma are primarily treated at the National Institute of Neurology and Neurosurgery and the National Institute of Oncology. Epidemiological data is incomplete due to the lack of a national cancer registry. In the case of neoplasms of the central nervous system, the available information suggests that gliomas represent 33% of all intracranial tumors. The treatment of patients in Mexico diagnosed with glioblastoma has not been standardized owing to the lack of resources in some communities and the expense of antineoplastic agents. Current options range from a biopsy only to maximal safe resection followed by adjuvant treatment with radiation and chemotherapy.Currently, basic science and clinical research is being conducted in academic institutions associated with universities and in private hospitals. Studies include the evaluation of tumor biology, neuroimaging biomarkers and new treatment options such as the use of chloroquine.

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“…The expression of RAS components has been linked to the hallmarks of cancer due to an upregulation of such components in some cancer types [9,10,69]. The function of RAS has been involved in proliferative signaling, growth suppressor evasions, apoptosis resistance, angiogenesis, cellular energetics deregulation, inflammation, cellular migration, invasion and metastasis [70].…”

Section: -Ace2 and Cancermentioning

confidence: 99%

ACE2: THE DOORWAY TO SARS-CoV-2

Medina-Enríquez¹,

Carlos-Escalante²,

Aponte-Torres³

et al. 2020

Preprint

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The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 71 different cell types. Some factors that can affect the expression of the ACE2 are: sex, environment, lifestyles, comorbidities, medications (e.g. anti-hypertensives) and its interaction with other genes of the renin-angiotensin system and other pathways. All of these factors can affect the risk of infection of SARS-CoV-2 and determine the severity of the symptoms. The ACE2 enzyme is a negative regulator of RAS expressed in various organ systems. It has been seen to be associated with immunity, inflammation, increased coagulopathy, and cardiovascular disease. In this review, we describe the genetic and molecular functions of the ACE2 receptor and its relation with the physiological and pathological conditions to better understand how this receptor is involved in the pathogenesis of COVID-19.

show abstract

Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma

Cited by 16 publications

References 53 publications

ACE2: the molecular doorway to SARS-CoV-2

ACE2: the molecular doorway to SARS-CoV-2

Management of glioblastoma: a perspective from Mexico

ACE2: THE DOORWAY TO SARS-CoV-2

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