Angiotensin receptors in vascular tissue

Angiotensin Receptors in Bovine Umbilical Artery and Their Inhibition by Nonsteroidal Anti‐inflammatory Drugs

“…The high affinity site had an apparent dissociation constant of 5 nm. This was less than the mean dose for (Lin, Ellis, Weisblum & Goodfriend, 1970;Devynck & Meyer, 1976). Finally, the difference may have reflected a lack of proportionality between receptor occupancy and response.…”

Central actions and brain receptor binding of angiotensin II: Influence of sodium intake.

“…Like other hormones," All interacts with a specific receptor on its target cell. There is evidence for the existence of these receptors in the adrenal gland," in smooth muscle, 26 and in brain. 7 ' * Our investigations confirm the existence of specific, saturable highaffinity binding sites for All in the rat brain.…”

The effect of altered sodium balance upon renal vascular reactivity to angiotensin II and norepinephrine in the dog. Mechanism of variation in angiotensin responses.

“…The Journal of Clinical Investigation Volume 61 Marchi 1978 *610-623Four major hypotheses have been proposed to explain the inverse relationship l)etween the state of sodium balance and the magniitude of the vascular response to A,,: (a) that sodiumii has a direct effect upon the contractile response of vascular smiiooth muscle induced by A,, (9,11,18), (b) that the vasoconstrictor response to exogenous A,, is inversely related to the degree to which the vascular All receptors are occupied by endogenouis polypeptide (6,19), (c) that the concentratioin of All receptors in vascular smooth muscle is variable and that this concentration determines the vascular response to the hormone (20), and (d) that the vasoconstrictioni produced by Al, is modulated by the conicomitant vasodilator action of other hormones with opposing effects (e.g., prostaglandinls) (21).…”