Angiotensin receptors — evolutionary overview and perspectives

Nishimura, Hiroko

doi:10.1016/s1095-6433(00)00294-4

Cited by 59 publications

(51 citation statements)

References 103 publications

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“…In fish, AT 1 receptors have been identified in several species, including eel, Anguilla anguilla; toadfish, Opsanus beta; and rainbow trout, Oncorhynchus mykiss (Nishimura 2001). Although Tucker et al (2007) reported the presence of putative AT 1 receptors in zebrafish, there is debate as to whether the ligand for this receptor is actually apelin rather than ANG-II (Zeng et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Although Tucker et al (2007) reported the presence of putative AT 1 receptors in zebrafish, there is debate as to whether the ligand for this receptor is actually apelin rather than ANG-II (Zeng et al 2007). Based on immunohistochemical staining with a mouse MAB, the AT 1 receptor was localised to osmoregulatory tissues, including ionocytes from eel gill (for review, see Nishimura (2001) and Russell et al (2001)). The results of this study revealed an inhibitory effect of AT 1 blockade (using telmisartan) on Na C uptake, indicating the probable involvement of AT 1 in mediating the stimulatory effect of ANG-II on Na C uptake in zebrafish.…”

Section: Discussionmentioning

confidence: 99%

“…As in mammals, the RAS is physiologically relevant in fish, where it is known to participate in fluid volume control and blood pressure regulation (Smith et al 1991, Tierney et al 1995, Bernier et al 1999b, Takei & Tsuchida 2000, Nishimura 2001, Russell et al 2001. While significant inter-species differences exist with respect to the mechanisms for blood pressure regulation by ANG-II (Bernier et al 1999b), plasma [ANG-II] and renin activities have often been reported to be transiently or chronically elevated following transfer to seawater in several euryhaline fish species (Smith et al 1991, Tierney et al 1995, Anderson et al 2006.…”

Section: Introductionmentioning

confidence: 99%

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Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water

Kumai

Bernier

Perry

2013

Journal of Endocrinology

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The contribution of the renin-angiotensin system (RAS) to Na C uptake was investigated in larval zebrafish (Danio rerio). At 4 days post fertilization (dpf), the level of whole-body angiotensin-II (ANG-II) was significantly increased after 1-or 3-h exposure to acidic (pHZ4.0) or ion-poor water (20-fold dilution of Ottawa tapwater), suggesting rapid activation of the RAS. Long-term (24 h) treatment of 3 dpf larvae with ANG-I or ANG-II significantly increased Na C uptake which was accompanied by an increase in mRNA expression of the NaInduction of Na C uptake by exposure to ANG-I was blocked by simultaneously treating larvae with lisinopril (an angiotensin-converting enzyme inhibitor). Acute (2 h) exposure to acidic water or ion-poor water led to significant increase in Na C uptake which was partially blocked by the ANG-II receptor antagonist, telmisartan. Consistent with these data, translational knockdown of renin prevented the stimulation of Na C uptake following exposure to acidic or ion-poor water. The lack of any effects of pharmacological inhibition (using RU486), or knockdown of glucocorticoid receptors on the stimulation of Na C uptake during acute exposure to acidic or ion-poor environments, indicates that the acute effects of RAS occur independently of cortisol signaling. The results of this study demonstrate that the RAS is involved in Na C homeostasis in larval zebrafish. Key Words" angiotensin-II" cortisol " zebrafish " osmoregulation " ion-poor water " acidic water

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water

Kumai

Bernier

Perry

2013

Journal of Endocrinology

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“…The hemodynamic mechanisms of AngII are primarily mediated through activation of the type 1 angiotensin receptor (AT 1 ; Saavedra 2005) localized to brain regions involved in autonomic function (Ando et al 2004). Increased brain RAS activity is associated with increased AT 1 expression in cerebral arteries and microvessels promoting endothelial dysfunction, vascular inflammation, and blood-brain barrier permeability (Nishimura 2001;Ando et al 2004;Saavedra et al 2006). This AT 1 -induced pathophysiological cascade is characteristic of aging phenotypes causing progressive changes in cerebral circulation and white matter microstructure (Nation et al 2010;Saavedra et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

Salminen

Schofield

Pierce

et al. 2014

AGE

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Vascular aging consists of complex and multifaceted processes that may be influenced by genetic polymorphisms of the renin-angiotensin system. A polymorphism in the angiotensin II type 1 receptor gene (AGTR1/rs5186) has been associated with an increased risk for arterial stiffness, hypertension, and ischemic stroke. Despite these identified relationships, the impact of AGTR1 A1166C on white matter integrity and cognition is less clear in a healthy aging population. The present study utilized indices of neuroimaging and neuropsychological assessment to examine the impact of the A1166C polymorphism on subcortical hyperintensities (SH) and cognition in 49 healthy adults between ages 51-85. Using a dominant statistical model (CC + CA (risk) vs. AA), results revealed significantly larger SH volume for individuals with the C1166 variant (p<0.05, partial eta 2 = 0.117) compared with those with the AA genotype. Post hoc analyses indicated that increased SH volume in C allele carriers could not be explained by vascular factors such as pulse pressure or body mass index. In addition, cognitive performance did not differ significantly between groups and was not significantly associated with SH in this cohort. Results suggest that presence of the C1166 variant may serve as a biomarker of risk for suboptimal brain integrity in otherwise healthy older adults prior to changes in cognition.

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“…Although two main subtypes of AII receptors, AT1 and AT2, have been identified, the AT2 receptors are found primarily in fetal tissues and in pathophysiological conditions (Nishimura 2001); experimental evidence from many adult tissues suggests that AT1 receptors predominate (Sayeski et al 1998, Nishimura 2001 and there is some evidence for AT1 receptors in spermatozoa. However, earlier studies produced conflicting results, with Vinson et al (1995) reporting AT1 receptors to be located on the flagella of mature rat and human spermatozoa and Wennemuth et al (1999) reporting that these receptors were located on both the acrosomal region of the head and the principal piece of mature mouse spermatozoa.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin II stimulates cAMP production and protein tyrosine phosphorylation in mouse spermatozoa

Mededovic

Fraser

2004

Reproduction

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Angiotensin II (AII), found in seminal plasma, has been shown to stimulate capacitation in uncapacitated mammalian spermatozoa. The present study investigated the location of AII receptors on spermatozoa and AII's mechanism of action. AT1 type receptors for AII are present on the acrosomal cap region and along the whole of the flagellum of both mouse and human spermatozoa. Because combinations of low concentrations of AII and either calcitonin or fertilization-promoting peptide (FPP), both known to regulate the adenylyl cyclase (AC)/cAMP signal transduction pathway, elicited a significant response, this study investigated the hypothesis that these peptides act on the same pathway. AII was shown to significantly stimulate cAMP production in both uncapacitated and capacitated mouse spermatozoa and this was associated with increases in protein tyrosine phosphorylation. Using an anti-phosphotyrosine antibody to visualize the location of tyrosine phosphoproteins within individual cells, AII significantly stimulated phosphorylation within 20 min in both the head, especially in the acrosomal cap region, and the flagellum, especially in the principal piece, of uncapacitated mouse spermatozoa; combined AII 1 FPP was stimulatory within 5 min. In addition, Western blotting revealed that AII stimulation increased phosphorylation in a number of tyrosine phosphoproteins in both uncapacitated and capacitated mouse spermatozoa, with some being altered only in the latter category of cells. These results support the hypothesis that AII stimulates AC/cAMP in mammalian spermatozoa.

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Angiotensin receptors — evolutionary overview and perspectives

Cited by 59 publications

References 103 publications

Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water

Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

Angiotensin II stimulates cAMP production and protein tyrosine phosphorylation in mouse spermatozoa

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