Angiotensin peptides in the non-gravid uterus: Paracrine actions beyond circulation

Casalechi, Maíra; Cruz, Cynthia Dela; Lima, Luiza Cioglia Dias; Maciel, Luciana P.; Pereira, Virginia M.; Reis, Fernando M.

doi:10.1016/j.peptides.2018.01.012

Cited by 5 publications

(6 citation statements)

References 63 publications

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“…Other scientific studies claim that oestrogens and progesterone directly influence brain function through oestrogen receptors located on neurons in several regions of the brain, through their neuroprotective and neurotrophic effects. At the same time, it stimulates the production of nerve growth factors, thus promoting neuronal growth and viability, the repair of damaged neurons and dendritic branches [7]. Also, quite recently, it has been found that progesterone or progestin could inhibit or accelerate neuroplasticity by preventing microglia from eliminating free radicals or by stimulating myelin production.…”

Section: Figure 6 Dose-effect Comparison Between Control Contraction and Frequency-effect Curve For Angiotensin IImentioning

confidence: 99%

“…However, the close similarity and the synthesis relationship between the molecules of progesterone and aldosterone might induce alterations in the plasma concentration of aldosterone, with effects on the hydric homeostasis [33]. In this way, some studies showed that oestrogen plays an important role in mediating the gestational increase in uterine artery blood flow, considering that the AT2 receptor-mediated responses are regulated in the presence of oestrogen and it increases substantially during pregnancy [7]. Also, given the findings that oestradiol also plays an important role in increasing uterine arterial blood flow [28], we suggest that oestradiol regulates AT2 receptors in uterine arteries.…”

Section: Figure 6 Dose-effect Comparison Between Control Contraction and Frequency-effect Curve For Angiotensin IImentioning

confidence: 99%

“…In fact, Ang II-induced contractile responses in intact uterine arteries of the endothelium in nulliparous mice were significantly decreased, when compared to multiparous mice [28]. Still, as the available data is still inconclusive, further evidence is clearly needed to verify the role of the local renin-angiotensin system in the physiological regulation of the endometrium and myometrium [7]. In this way, future studies should evaluate this local system in human uterine disorders.…”

Section: Figure 6 Dose-effect Comparison Between Control Contraction and Frequency-effect Curve For Angiotensin IImentioning

confidence: 99%

“…Studies on this topic suggest improved performance when we have high levels of oestradiol during the menstrual cycle. Studies of the menstrual cycle on emotional processing, on the other hand, demonstrate the emotional disorders of the luteal phase and may be relevant for women with premenstrual disorders [7,26]. Among the primary female sex hormones, we studied oestrogen and progesterone.…”

Section: Introductionmentioning

confidence: 99%

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Neurohormonal and Pharmacological Regulation of Oestrogen, Progesterone, Luteinizing Hormone and Follicle Stimulating Hormone Over the Menstrual Cycle – The Possible Relevance of Angiontensin Ii

Barbu¹

2021

FARMACIA

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The menstrual cycle is a series of physiological changes that occur under hormonal control in females during the childbearing age. Its neurohormonal regulation is made via the hypothalamic-pituitary-ovarian axis that regulates hormones levels like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and indirectly via oestrogens and progesterone. Their plasma levels can vary during the phases of the menstrual cycle: the follicular, ovulatory and luteal phase. Changes in hormonal balance, in the luteinizing hormone and follicle-stimulating hormone alter the oestrogen/progesterone balance, and can disrupt the menstrual cycle. The aim of this study was to explore the reciprocal relationships between sex steroid hormones, oestrogen and progesterone and gonadotropic hormones, such as luteinizing hormone and follicle-stimulating hormone, during the physiological ovulatory menstrual cycle. For this study we used 20 nulliparous female mice and 15 multiparous female mice. The obtained results show that plasma concentrations of luteinizing hormone, follicle-stimulating hormone and oestrogens were altered significantly between the phases of the menstrual cycle in nulliparous compared to multiparous female mice, but the progesterone values were not different for the two groups of mice studied. It is recognized that ovarian factors, including steroid and protein hormones, are critical in regulating pituitary gonadotropin feedback, but nevertheless, their individual contributions are less defined. We have shown that the administration of angiotensin II, in the same nulliparous and multiparous female mice, in which the hormonal assessment was performed, significantly increases the muscular contractility stimulated by the electric field. RezumatCiclul menstrual este reprezentat de o serie de modificări fiziologice care se produc sub control hormonal la sexul feminin în timpul vârstei fertile. Reglarea neurohormonală este reprezentată de axa hipotalamo-hipofizo-ovariană care reglează ciclul menstrual. Nivelele de hormoni, precum estrogenul, progesteronul, hormonul luteinizant (LH) și hormonul foliculostimulant (FSH), pot varia în timpul fazelor ciclului menstrual: faza foliculară, ovulatorie și luteală. Modificările echilibrului hormonal, hormonul luteinizant și hormonul foliculostimulant, ale balanței estrogeni/progesteron pot perturba ciclul menstrual. Scopul acestui studiu a fost explorarea relațiilor reciproce dintre hormonii steroizi sexuali, estrogeni și progesteron și hormonii gonadotropi, precum hormonul luteinizant și hormonul foliculostimulant, de-a lungul ciclului ovulator fiziologic. Pentru acest studiu am folosit 20 șoareci femele nulipare și 15 șoareci femele multipare, de la care sângele a fost colectat și ulterior analizat în laborator. Rezultatele obținute arată că hormonul luteinizant, hormonul foliculostimulant și estrogenii s-au schimbat semnificativ între fazele ciclului menstrual la nulipare comparativ cu șoarecii femele multipare, dar valorile progesteronului nu au fost modificate pentru cele dou...

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Section: Figure 6 Dose-effect Comparison Between Control Contraction and Frequency-effect Curve For Angiotensin IImentioning

confidence: 99%

Section: Figure 6 Dose-effect Comparison Between Control Contraction and Frequency-effect Curve For Angiotensin IImentioning

confidence: 99%

Section: Figure 6 Dose-effect Comparison Between Control Contraction and Frequency-effect Curve For Angiotensin IImentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neurohormonal and Pharmacological Regulation of Oestrogen, Progesterone, Luteinizing Hormone and Follicle Stimulating Hormone Over the Menstrual Cycle – The Possible Relevance of Angiontensin Ii

Barbu¹

2021

FARMACIA

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“…Such a wide range of influence carries a certain risk with it. Literature data unequivocally show a significant impact of mutations and single nucleotide polymorphism (SNP) of the ATR1 gene on upregulation of its product-AT1R, hence the disruption of the mentioned above cellular actions [3]. The balance between the activation of individual receptors allows to maintain the correct states between vasoconstriction and vasodilation, or between pro-and antiinflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin II and Angiotensin Receptors 1 and 2—Multifunctional System in Cells Biology, What Do We Know?

Ziaja

Urbanek

Kowalska

et al. 2021

Cells

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For years, the renin-angiotensin system (RAS) has been perceived as a system whose role is to primarily modulate the functioning of the cardiovascular system. Years of research into the role of RAS have provided the necessary data to confirm that the role of RAS is very complex and not limited to the cardiovascular system. The presence of individual elements of the renin-angiotensin (RA) system allows to control many processes, ranging from the memorization to pro-cancer processes. Maintaining the proportions between the individual axes of the RA system allows for achieving a balance, often called homeostasis. Thus, any disturbance in the expression or activity of individual RAS elements leads to pathophysiological processes.

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Renin-angiotensin system in normal pregnancy and in preeclampsia: A comprehensive review

Leal

Costa

Ferreira

et al. 2022

Pregnancy Hypertension

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Angiotensin peptides in the non-gravid uterus: Paracrine actions beyond circulation

Cited by 5 publications

References 63 publications

Neurohormonal and Pharmacological Regulation of Oestrogen, Progesterone, Luteinizing Hormone and Follicle Stimulating Hormone Over the Menstrual Cycle – The Possible Relevance of Angiontensin Ii

Neurohormonal and Pharmacological Regulation of Oestrogen, Progesterone, Luteinizing Hormone and Follicle Stimulating Hormone Over the Menstrual Cycle – The Possible Relevance of Angiontensin Ii

Angiotensin II and Angiotensin Receptors 1 and 2—Multifunctional System in Cells Biology, What Do We Know?

Renin-angiotensin system in normal pregnancy and in preeclampsia: A comprehensive review

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