Angiotensin IV and the human esophageal mucosa: An exploratory study in healthy subjects and gastroesophageal reflux disease patients

Abstract

The AT4R and formation enzymes of AngIII and AngIV are present in the human esophageal epithelium. Moreover, the present results suggest that AngIV exert regulatory impact on the epithelium and that RAS is involved in mucosal aberrations associated with GERD.

Local expression of AP/AngIV/IRAP and effect of AngIV on glucose-induced epithelial transport in human jejunal mucosa

“…23 In a recent study we showed that the AP/AngIV/IRAP axis was expressed and functional in the human esophageal mucosa. 24 However, no data are available describing the effects of the AP/AngIV/IRAP axis in the human small intestine.…”