Angiotensin II stimulation of granuloma macrophage phagocytesis and actin polymerization in murine schistosomiasis mansoni

Angiotensin II Increases Macrophage-mediated Modification of Low Density Lipoprotein via a Lipoxygenase-dependent Pathway

“…While most of the known physiological and pathophysiological actions of Ang II (hemodynamics, aldosterone release, growth of vascular cells) have been attributed to the AT 1 receptor, the role of the AT 2 subtype is less clear (48). We document the presence of Ang II AT 1 receptors on MPM and the J-774 cell line with an apparent K d of 0.18 and 0.50 nM, respectively, which is in agreement with studies on macrophages isolated from murine liver granulomas following Schistosoma mansoni infection (49). The fact that only an AT 1 receptor antagonist was able to compete for the Ang II binding on MPM and J-774, suggests that AT 1 -binding sites are present and that binding of Ang II to its receptor is required for the Ang II-induced effects.…”

Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor.

“…Moreover, it has been reported that ANG II activates M/M under certain circumstances (54,55). In our experiments, ANG II alone was not chemotactic for human monocytes and the chemotactic activity of conditioned supernatants from ANG II-treated GER was abolished in the presence of the neutralizing anti-RANTES antibody, strongly indicating that induction of RANTES is necessary, and ANG II per se is not chemotactic for monocytes in our experimental setting.…”

AT1 receptor characteristics of angiotensin analogue binding in human synovium

“…In addition to effects on vascular tone and smooth muscle growth, microvascular angiotensin receptors may regulate endothelial permeability (Morel et al, 1990) and neovascularisation (Fernandez et al, 1985;Le Noble et al, 1991 (Thomas & Hoffman, 1994) and fibroblasts (Millan et al, 1989) have previously been shown to express angiotensin receptors in culture. In vitro, angiotensin inhibits macrophage migration (Weinstock & Blum, 1983) and may increase phagocytosis (Weinstock & Kassab, 1984), although the relevance of these observations to macrophage function in vivo remains uncertain. Angiotensin receptor subtypes have been extensively studied in foetal rat skin fibroblasts.…”