“…Furthermore, electrophysiological studies showed an increase of gCl in the PKC𝜃-null mice with respect to wild-type, and a consequent reduction of muscle excitability ( Camerino et al, 2014 ). Regulation of ClC-1 channels through PKC-dependent phosphorylation appeared to be involved in the muscular effects of a number of growth factors, hormones, and drugs, including the growth hormone, insulin-like growth factor-1 (IGF-1), ghrelin, angiotensin II, growth hormone secretagogues, and statins ( De Luca et al, 1994b , 1998 ; Pierno et al, 2003 ; Cozzoli et al, 2014 ).…”