Angiotensin II inhibition of Ca2+ currents is independent of ATR1 angiotensin II receptor activation in rat adult vagal afferent neurons

Moreira, Thaı́s Helena; Rodrigues, Andreia Laura Prates; Beirão, Paulo Sérgio Lacerda; Santos, Robson; Cruz, Jáder Santos

doi:10.1016/j.autneu.2004.11.002

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…12 In Figure 2. addition, our previous data indicated that sex-specific distribution of myelinated Ah-type BRNs are likely to be involved in sex difference of neurocontrol of circulation, 3,13,21,24 which supports the observation that the mRNA expression of AT 2 R was found mainly in myelinated Ah-types by the single-cell RT-PCR analysis ( Figure 2D).…”

Section: Effects Of Ang-ii On Discharge Profiles Of Identified Ah-typmentioning

confidence: 99%

“…The sex differences in neurocontrol of circulation at baroreflex level have almost been neglected although AT 1 R or AT 2 R has been identified in nodose ganglia (NG) or nucleus of tractus solitary (NTS). 11,12 Recent literatures have shown that adult female rats express Abstract-This study aims to understand the special expression patterns of angiotensin-II receptor (AT 1 R and AT 2 R) in nodose ganglia and nucleus of tractus solitary of baroreflex afferent pathway and their contribution in sex difference of neurocontrol of blood pressure regulation. In this regard, action potentials were recorded in baroreceptor neurons (BRNs) using whole-cell patch techniques; mRNA and protein expression of AT 1 R and AT 2 R in nodose ganglia and nucleus of tractus solitary were evaluated using real time-polymerase chain reaction, Western blot, and immunohistochemistry at both tissue and single-cell levels.…”

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confidence: 99%

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Unique Expression of Angiotensin Type-2 Receptor in Sex-Specific Distribution of Myelinated Ah-Type Baroreceptor Neuron Contributing to Sex-Dimorphic Neurocontrol of Circulation

Yang

Zhou

et al. 2016

Hypertension

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T he sex difference in blood pressure (BP) has long been recognized between premenopausal women and agedmatched men.1 Women are protected from most cardiovascular events compared with age-matched men before menopause, and postmenopausal women are at increased risk of cardiovascular complications compared with premenopausal women. 2 The pathophysiological mechanisms have been extensively explored, and increasing evidences have shown that the female hormone is one of the major mechanisms contributing to the above phenomena.3 Several studies have demonstrated the importance of the interaction between sex hormones and the renin-angiotensin system in regulating cardiovascular function and BP. 4,5 Angiotensin-II (Ang-II) is a key player in the development of hypertension. Ang-II type-1 (AT 1 R) and type-2 (AT 2 R) receptors play opposite roles in BP regulation, 6,7 with AT 2 R exerting a cardioprotective action in essential hypertension. 8 Early study demonstrates that AT 2 R provides a major clue for solving the mystery of sex differences in AT 2 R-mediated vasodilation 9 and hypertension. 10 However, the majority of researches on hypertension to date has been conducted in male animals and focused largely on the target organs, such as the heart, blood vessels, and kidney. The sex differences in neurocontrol of circulation at baroreflex level have almost been neglected although AT 1 R or AT 2 R has been identified in nodose ganglia (NG) or nucleus of tractus solitary (NTS). 11,12 Recent literatures have shown that adult female rats express Abstract-This study aims to understand the special expression patterns of angiotensin-II receptor (AT 1 R and AT 2 R) in nodose ganglia and nucleus of tractus solitary of baroreflex afferent pathway and their contribution in sex difference of neurocontrol of blood pressure regulation. In this regard, action potentials were recorded in baroreceptor neurons (BRNs) using whole-cell patch techniques; mRNA and protein expression of AT 1 R and AT 2 R in nodose ganglia and nucleus of tractus solitary were evaluated using real time-polymerase chain reaction, Western blot, and immunohistochemistry at both tissue and single-cell levels. The in vivo effects of 17β-estradiol on blood pressure and AT 2 R expression were also tested. The data showed that AT 2 R, rather than AT 1 R, expression was higher in female than age-matched male rats. Moreover, AT 2 R was downregulated in ovariectomized rats, which was restored by the administration of 17β-estradiol. Single-cell real time-polymerase chain reaction data indicated that AT 2 R was uniquely expressed in Ah-type BRNs. Functional study showed that long-term administration of 17β-estradiol significantly alleviated the blood pressure increase in ovariectomized rats. Electrophysiological recordings showed that angiotensin-II treatment increased the neuroexcitability more in Ah-than C-type BRNs, whereas no such effect was observed in A-types. In addition, angiotensin-II treatment prolonged action potential duration, which was not further changed...

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Section: Effects Of Ang-ii On Discharge Profiles Of Identified Ah-typmentioning

confidence: 99%

mentioning

confidence: 99%

Unique Expression of Angiotensin Type-2 Receptor in Sex-Specific Distribution of Myelinated Ah-Type Baroreceptor Neuron Contributing to Sex-Dimorphic Neurocontrol of Circulation

Yang

Zhou

et al. 2016

Hypertension

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“…These channels all are involved in the initiation and formation of the action potential and affect the nodose neuron excitability. Angiotensin II is known to modulate the calcium channel kinetics in the nodose neurons (Bacal & Kunze, 1994;Moreira et al, 2005). However, until now we did not obtain any information about the changes of these channels in the aortic baroreceptor neurons in the type 1 diabetes.…”

Section: Role Of Other Channels In the Aortic Baroreceptor Neuron In mentioning

confidence: 64%

Cardiovascular Autonomic Dysfunction in Diabetes as a Complication: Cellular and Molecular Mechanisms

Li¹

2011

Type 1 Diabetes Complications

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The contribution of angiotensin peptides to cardiovascular neuroregulation in health and disease

et al. 2023

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Angiotensin II inhibition of Ca2+ currents is independent of ATR1 angiotensin II receptor activation in rat adult vagal afferent neurons

Cited by 5 publications

References 27 publications

Unique Expression of Angiotensin Type-2 Receptor in Sex-Specific Distribution of Myelinated Ah-Type Baroreceptor Neuron Contributing to Sex-Dimorphic Neurocontrol of Circulation

Unique Expression of Angiotensin Type-2 Receptor in Sex-Specific Distribution of Myelinated Ah-Type Baroreceptor Neuron Contributing to Sex-Dimorphic Neurocontrol of Circulation

Cardiovascular Autonomic Dysfunction in Diabetes as a Complication: Cellular and Molecular Mechanisms

The contribution of angiotensin peptides to cardiovascular neuroregulation in health and disease

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