Angiotensin II induces the generation of procoagulant microparticles by human mononuclear cells via an angiotensin type 2 receptor-mediated pathway

Cordazzo, Cinzia; Neri, Tommaso; Petrini, Silvia; Lombardi, Stefania; Balia, Cristina; Cianchetti, Silvana; Carmazzi, Yuri; Paggiaro, Pierluigi; Pedrinelli, Roberto; Celi, Alessandro

doi:10.1016/j.thromres.2013.01.019

Cited by 34 publications

(27 citation statements)

References 44 publications

(61 reference statements)

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“…This effect is due to microparticles carrying ACE, which activate EC AT 1 R, Nox, and downstream p38MAPK and ERK1/2 (3). Likewise, ANG II stimulates procoagulant microparticle release from human mononuclear cells that is dependent upon AT 2 R-mediated mobilization of intracellular Ca 2ϩ (185). In addition, high glucose plus ANG II combination enhances production of extracellular vesicles (mixture of microparticles and exosomes), which in turn stimulate ERK1/2 and reduce eNOS expression and NO production in human umbilical endothelial cells (HUVECs) (1026).…”

Section: Microparticle and Exosomementioning

confidence: 99%

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Forrester

Booz

Sigmund

et al. 2018

Physiological Reviews

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The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have been unclear. The angiotensin II (ANG II) type 1 receptor (ATR) is believed to mediate most functions of ANG II in the system. ATR utilizes various signal transduction cascades causing hypertension, cardiovascular remodeling, and end organ damage. Moreover, functional cross-talk between ATR signaling pathways and other signaling pathways have been recognized. Accumulating evidence reveals the complexity of ANG II signal transduction in pathophysiology of the vasculature, heart, kidney, and brain, as well as several pathophysiological features, including inflammation, metabolic dysfunction, and aging. In this review, we provide a comprehensive update of the ANG II receptor signaling events and their functional significances for potential translation into therapeutic strategies. ATR remains central to the system in mediating physiological and pathophysiological functions of ANG II, and participation of specific signaling pathways becomes much clearer. There are still certain limitations and many controversies, and several noteworthy new concepts require further support. However, it is expected that rigorous translational research of the ANG II signaling pathways including those in large animals and humans will contribute to establishing effective new therapies against various diseases.

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Section: Microparticle and Exosomementioning

confidence: 99%

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Forrester

Booz

Sigmund

et al. 2018

Physiological Reviews

728

756

View full text Add to dashboard Cite

show abstract

“…Moreover, some PPAR-γ agonists have been linked to an increased risk of thrombotic diseases [44]. Interestingly, angiotensin II may up-regulate the generation of pro-coagulant MPs by human mononuclear cells that confirms a hypothesis about linking between the renin-angiotensin systems to thrombosis [45]. Therefore, there is evidence that elderly persons compared with young persons may have different patterns of expression of mononuclear cells derived MPs and pro-coagulant activity in stable condition and diseases [46].…”

Section: Biological Role and Function Of Mpsmentioning

confidence: 75%

The Clinical Utility of Circulating Microparticles’ Measurement in Heart Failure Patients

Berezin¹

2016

Vasc Med Surg

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Heart failure (HF) continues to have a sufficient impact on morbidity, mortality and disability in developed countries. Growing evidence supports the hypothesis that microparticles (MPs) might contribute to the pathogenesis of the HF development paling a pivotal role in the regulation of the endogenous repair system, thrombosis, coagulation, inflammation, immunity and metabolic memory phenomenon. Therefore, there is a large body of data clarifying the predictive value of MP numerous in circulation among subjects with HF. Although determination of MP signature is better than measurement of single MP circulating level, there is not yet closely confirmation that immune phenotype of cells produced MPs are important for HF prediction and development. The aim of the review: to summarize knowledge regarding the measurement of number of various MPs subsets in HF patients.

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“…Furthermore, Chymase and Cathepsin G can convert Angiotensin 1 into Angiotensin 2. It has been shown that Angiotensin 2 induces liberation of procoagulant microparticles, and thus may lead to thrombosis events . Therefore, downregulation of Serpina3K among DCS rats may affect both the renin–angiotensin system and DCS outcome.…”

Section: Discussionmentioning

confidence: 99%

Effect of simulated air dive and decompression sickness on the plasma proteome of rats

et al. 2016

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Angiotensin II induces the generation of procoagulant microparticles by human mononuclear cells via an angiotensin type 2 receptor-mediated pathway

Cited by 34 publications

References 44 publications

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

The Clinical Utility of Circulating Microparticles’ Measurement in Heart Failure Patients

Effect of simulated air dive and decompression sickness on the plasma proteome of rats

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