Angiotensin II-evoked enhanced expression of RGS2 attenuates Gi-mediated adenylyl cyclase signaling in A10 cells

Li, Yuan; Hashim, Shehla; Anand‐Srivastava, Madhu B.

doi:10.1016/j.cardiores.2005.02.005

Cited by 32 publications

(19 citation statements)

References 38 publications

(69 reference statements)

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“…The role of RGS-2 acting as a negative regulator of the a subunit of Gi protein (Gai2) has also been demonstrated in A10 vascular smooth muscle cells [70] through the attenuation of Gi-mediated inhibition of adenylyl cyclase. The resultant increased level of cAMP may play a role in the regulation of BP by decreasing vascular resistance [70].…”

Section: G Proteins and Regulator Of G Protein Signaling-2mentioning

confidence: 97%

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Understanding the mechanisms of angiotensin II signaling involved in hypertension and its long-term sequelae

Calò

Davis

Rossi

2014

Journal of Hypertension

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Angiotensin II (Ang II) plays a key role in hypertension, renal and cardiovascular pathophysiology via intracellular pathways that involve the activation of a multiplicity of signaling mechanisms. Although experimental and genetic animal models have been developed and used to explore Ang II signaling's role in hypertension, a complete understanding of the processes mediating Ang II signaling in hypertension in humans remains elusive. One impediment is that these animal models do not exhibit all the traits of human hypertension, making it impossible to extrapolate from them to humans. To overcome this issue, we have used patients with Bartter's and Gitelman's syndromes, a human model of endogenously blunted and blocked Ang II signaling that presents a constellation of clinical findings which manifest themselves as the opposite of hypertension. This article reviews the aspects of the pathophysiology of human hypertension and its short and long term sequelae, and uses the results of our studies in Bartter's and Gitelman's syndromes along with those of others to gain better insight and understanding of the role of Ang II signaling in these processes.

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Section: G Proteins and Regulator Of G Protein Signaling-2mentioning

confidence: 97%

“…The resultant increased level of cAMP may play a role in the regulation of BP by decreasing vascular resistance [70].…”

Section: G Proteins and Regulator Of G Protein Signaling-2mentioning

confidence: 99%

Understanding the mechanisms of angiotensin II signaling involved in hypertension and its long-term sequelae

Calò

Davis

Rossi

2014

Journal of Hypertension

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“…A single agonist may also upregulate more than one RGS in the same tissue. For example, Ang II upregulates both the R4-RGS RGS2 and the GEF-RGS GEF leukemia-associated Rho-GEF (LARG) in vascular smooth muscle cells [145,146]. The increase in RGS2 may be responsible for the ability of AngII to decrease Gi-mediated inhibition of adenylyl cyclase.…”

Section: Induction Of Rgss By Gpcr Stimulation: Feedback Inhibition Omentioning

confidence: 98%

Regulatory mechanisms involved in modulating RGS function

Jean-Baptiste

Yang

Greenwood

2006

Cell. Mol. Life Sci.

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Regulator of G-Protein Signaling (RGS) refers to a conserved 120-125 amino acid motif that was first identified by its ability to negatively regulate G-Protein-Coupled Receptor (GPCR) signalling. Mechanistically, RGSs were found to regulate GPCR responses by binding to and stimulating the GTPase activity of the receptor-activated GTP-bound G alpha subunits. There are now over 25 mammalian RGSs containing proteins that are reported to carry out a variety of functions, many of which are unrelated to GPCR signalling. RGS proteins range in size from small proteins that contain little more than an RGS box to very large proteins that contain a variety of domains. The selectivity of function of the RGS proteins is attributable to the divergence of the RGS sequences as well as the presence of a variety of functional motifs, which allow them to interact with other proteins. Here we focus on the RGSs that are involved in modulating GPCR signalling by reviewing the diversity of the mechanisms involved in regulating these RGSs.

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“…Ang II-stimulated expression of RGS2 inhibits both Ang II signalling [21] and aldosterone production [20] to prevent cell overstimulation. On the contrary, in our cohort resistant hypertension was associated with low RGS2, suggesting that increased vascular tone of the resistance vessels is due to unopposed Ang II-mediated vasoconstriction.…”

Section: Discussionmentioning

confidence: 99%

RGS2 expression and aldosterone: renin ratio modulate response to drug therapy in hypertensive patients

Semplicini

Strapazzon²,

Papparella³

et al. 2010

Journal of Hypertension

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Angiotensin II-evoked enhanced expression of RGS2 attenuates Gi-mediated adenylyl cyclase signaling in A10 cells

Abstract: These results suggest that RGS2 may be involved in short-term regulation of Ang II-induced Gi-mediated adenylyl cyclase signalling.

Cited by 32 publications

References 38 publications

Understanding the mechanisms of angiotensin II signaling involved in hypertension and its long-term sequelae

Understanding the mechanisms of angiotensin II signaling involved in hypertension and its long-term sequelae

Regulatory mechanisms involved in modulating RGS function

RGS2 expression and aldosterone: renin ratio modulate response to drug therapy in hypertensive patients

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