Angiotensin II directly induces follicle rupture and oocyte maturation in the rabbit

Yoshimura, Yasunori; Karube, Masataka; Koyama, Norihiro; Shiokawa, Shigetatsu; Nanno, Takuma; Nakamura, Yukio

doi:10.1016/0014-5793(92)80701-h

Cited by 77 publications

(61 citation statements)

References 21 publications

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“…Captopril (an ACE inhibitor) did not inhibit ovulation in rats (Daud et al 1990). In contrast, the Ang II type 2 receptor (AGTR2) blocker inhibited ovulation in the rabbit and bovine (Yoshimura et al 1992, Ferreira et al 2007, suggesting the presence of an alternative enzymatic route to the synthesis of ovarian Ang II. The members of plasminogen activator (PA) family, cathepsin D and chymase, are enzyme candidates to convert Ang I into the octapeptide Ang II (for review see Paul et al (2006)).…”

Section: Ovarian Rasmentioning

confidence: 95%

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Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

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Angiotensin (Ang) II is widely known for its role in the control of systemic blood vessels. Moreover, Ang II acts on the vascular control of ovarian function, corpus luteum formation, and luteolysis. Over the past 10 years, our research group has been studying the new concept of the renin-angiotensin system (RAS) as an autocrine/paracrine factor regulating steroidogenesis and promoting different cellular responses in the ovary, beyond vascular function. We have developed and used different in vivo and in vitro experimental models to study the role of RAS in the ovary and a brief overview of our findings is presented here. It is widely accepted that there are marked species differences in RAS function in follicle development. Examples of species-specific functions of the RAS in the ovary include the involvement of Ang II in the regulation of follicle atresia in rats vs the requirement of this peptide for the dominant follicle development and ovulation in rabbits and cattle. More recently, Ang-(1-7), its receptor, and enzymes for its synthesis (ACE2, NEP, and PEP) were identified in bovine follicles, implying that Ang-(1-7) has an ovarian function. Other novel RAS components (e.g. (pro)renin receptor and renin-binding protein) recently identified in the bovine ovary show that ovarian RAS is poorly understood and more complex than previously thought. In the present review, we have highlighted the progress toward understanding the paracrine and autocrine control of ovarian antral follicle development and ovulation by ovarian tissue RAS, focusing on in vivo studies using cattle as a model.

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Section: Ovarian Rasmentioning

confidence: 95%

“…Ang II is capable of inducing ovulation in rabbits even in the absence of gonadotropins (Kuo et al 1991, Yoshimura et al 1992. The effect of Ang II during ovulation is mediated, at least in part, by PGs.…”

Section: Ang II Signaling and Receptors Near Ovulationmentioning

confidence: 99%

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

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“…In cows, the AngII receptor type 2 is present in the dominant follicle (Schauser et al 2001), and its mRNA expression was positively correlated with estradiol production (Portela et al 2006). In perfused rabbit ovaries, the ovulation and the meiosis resumption induced by hCG are blocked by saralasin (1-sarcosine-8-alanine-5-isoleucine-AngII, a competitive AngII antagonist; Yoshimura et al 1992). In contrast, Kuo et al (1991) reported that saralasin inhibited ovulation without affecting oocyte nuclear maturation in rabbits.…”

Section: Introductionmentioning

confidence: 99%

Evidence that the effect of angiotensin II on bovine oocyte nuclear maturation is mediated by prostaglandins E2 and F2α

Barreta

Oliveira²,

Ferreira³

et al. 2008

Reproduction

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Angiotensin II (AngII) prevents the inhibitory effect of follicular cells on oocyte maturation, but its involvement in LH-induced meiotic resumption remains unknown. The aim of this study was to assess the involvement of AngII in LH-induced meiotic resumption and of prostaglandins (PGs) in the action of AngII. In the experiment I, seven cows were superovulated, intrafollicularly injected with 10 mM saralasin (a competitive AngII antagonist) or saline when the follicles reached a diameter larger than 12 mm, and challenged with a GnRH agonist to induce an LH surge. Fifteen hours after GnRH, the animals were ovariectomized and the oocytes were recovered to determine the stage of meiosis. The oocytes from follicles that received saline were in germinal vesicle (GV) breakdown (30.8%) or metaphase I (MI; 69.2%) stage while those that received saralasin were in the GV stage (100%; P!0.001) 15 h after GnRH agonist. In another experiment, oocytes were co-cultured with follicular hemisections for 15 h to determine whether PGs mediate the effect of AngII on meiotic resumption. Indomethacin (10 mM) inhibited AngII-induced meiotic resumption (13.4 vs 77.5% MI without indomethacin; P!0.001). Furthermore, the GV oocytes progressed to MI at a similar rate when PGE 2 , PGF 2a or AngII was present in the co-culture system with follicular cells (PGE 2 77.4%, PGF 2a 70.0%, and AngII 75.0% MI). In conclusion, our results provide strong evidence that AngII mediates the resumption of meiosis induced by an LH surge in bovine oocytes and that this event is dependent on PGE 2 or PGF 2a produced by follicular cells. Reproduction (2008) 136 733-740

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“…It is well known that the ovary has a local renin-angiotensin system, in which Ang II plays a crucial role in the processes of ovulation and oocyte maturation (Yoshimura et al, 1992). Here, we show that Ang II generates ion currents in isolated FCs in culture.…”

Section: Discussionmentioning

confidence: 55%

Ion Currents Induced by ATP and Angiotensin II in Cultured Follicular Cells of Xenopus laevis

Montiel‐Herrera

Zaske

Garcı́a-Colunga

et al. 2011

Molecules and Cells

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Xenopus laevis oocytes are commonly used to study the biophysical and pharmacological properties of foreign ion channels and receptors, but little is known about those endogenously expressed in their enveloping layer of follicular cells (FCs). Whole-cell recordings and the perforated patch-clamp technique in cultured FCs held at -60 mV revealed that ATP (20-250 μM) generates inward currents of 465 ± 93 pA (mean ± standard error) in ∼60% of the FCs studied, whereas outward currents of 317 ± 100 pA were found in ∼5% of the cells. The net effect of ATP on the FCs was to activate both mono-and biphasic inward currents, with an associated increase in membrane chloride conductance. Two-microelectrode voltage-clamp recordings of nude oocytes held at -60 mV disclosed that ATP elicited biphasic inward currents, corresponding to the well-known F in and S in -like currents. ATP receptor antagonists like suramin, TNP-ATP, and RB2 did not inhibit any of these responses. On the other hand, when using wholecell recordings, 1 μM Ang II yielded smooth inward currents of 157 ± 45 pA in ∼16% of the FC held at -60 mV. The net Ang II response, mediated by the activation of the AT 1 receptor, was a chloride current inhibited by 10 nM ZD7155. This study will help to better understand the roles of ATP and Ang II receptors in the physiology of X. laevis oocytes.

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Angiotensin II directly induces follicle rupture and oocyte maturation in the rabbit

Cited by 77 publications

References 21 publications

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Evidence that the effect of angiotensin II on bovine oocyte nuclear maturation is mediated by prostaglandins E2 and F2α

Ion Currents Induced by ATP and Angiotensin II in Cultured Follicular Cells of Xenopus laevis

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