Angiotensin II-binding sites in chicken brain and pituitary: autoradiographic localization

Natke, Charlotte; Gerstberger, Rüdiger; Großmann, Roland

doi:10.1007/s004410050539

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Angiotensin II is known to have positive effects on AVT secretion in birds (Gerstberger et al 1984;Goto et al 1986) and AVP secretion in mammals (Keil et al 1975;Yamamoto et al 1978;Simonnet et al 1979). These effects appear to be mediated by angiotensin II receptors within the AV3V region (Gerstberger et al 1987;Natke et al 1996).…”

Section: Discussionmentioning

confidence: 99%

c-fos Expression in the forebrain and brainstem of White Leghorn hens following osmotic and cardiovascular challenges

Jaccoby

Koike

Cornett

1999

Cell and Tissue Research

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In chickens, hyperosmolality and hemorrhage increase hypothalamic vasotocin (AVT) gene expression and stimulate the secretion of AVT from the posterior pituitary gland. In this study, c-fos expression was used to identify areas in the forebrain and brainstem of the domestic chicken that are activated following acute osmotic stress and hemorrhage-induced hypotension. Conscious hens were osmotically stimulated by administering a single intraperitoneal injection of 3 M NaCl (5 ml/kg). Urethane-anesthetized hens were bled to a mean systemic arterial pressure of 80-90 mm Hg and maintained at this blood pressure for 1 h with additional bleedings as required. In both studies, the expression of c-fos was determined in control and experimental birds by using Northern blot analysis and in situ hybridization analysis. Osmotic stress and hemorrhage-induced hypotension increased c-fos expression in the same brain regions. Prominent structures in the forebrain that expressed c-fos mRNA following acute osmotic stress and hemorrhage-induced hypotension included the supraoptic nucleus and paraventricular nucleus and nuclei within the hypothalamus that are anterior and ventral to the third ventricle. In the chicken, this region includes the organum subseptale, the o. vasculosum laminae terminalis, and the nucleus septalis medialis. In the brainstem, following either injection of 3 M NaCl or hemorrhageinduced hypotension, increased c-fos expression was observed in the nucleus of the solitary tract, parabrachial nucleus, area postrema, and locus ceruleus. Thus, the chicken central nervous system appears to use shared neuronal circuitry to stimulate hypothalamic AVT release in response to disturbances in body fluid composi-tion and decreases in either systemic blood pressure or volume.

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Section: Discussionmentioning

confidence: 99%

c-fos Expression in the forebrain and brainstem of White Leghorn hens following osmotic and cardiovascular challenges

Jaccoby

Koike

Cornett

1999

Cell and Tissue Research

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Angiotensin II Receptor Content Within the Circumventricular Organs Increases After Experimental Hydrocephalus in Rats

Açıkgöz

Akpınar

Bingol

et al. 1999

Acta Neurochirurgica

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Hydrocephalus is known to cause various endocrinological abnormalities. These abnormalities are either though a direct effect on anterior hypothalamus or pituitary gland. However almost nothing is known about the effects of hydrocephalus on the intrinsic angiotensin system of the brain. The aim of this study is to investigate the effect of hydrocephalus on neurotransmitter-rich circumventricular organ systems. Such an effect was investigated by means of angiotensin receptor content in subfornical organ (SFO), organum vasculosum lamina terminalis (OVLT), area postrema (AP) and the median eminence (ME). Experimental hydrocephalus was created in rats by the intracisternal kaolin injection method as described by Shapiro et al. The receptor content was measured at 4-6 weeks by in-vitro autoradiography method as described by Israel et al. Angiotensin II receptor content in hydrocephalic animals was found to be statistically increased in SFO, OVLT and ME but not in AP when compared with the normal animals. Receptor content was found to have increased by 182.4% at SFO, 76.7% at ME, 7.7% at AP and 22.1% at OVLT after kaolin injection. These findings may indicate the possible role of CVO's on pathological conditions such as hydrocephalus.

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Atypical angiotensin receptors may mediate water intake induced by central injections of angiotensin II and of serotonin in pigeons

Brun

Luz

Fernández

et al. 2001

Regulatory Peptides

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Angiotensin II-binding sites in chicken brain and pituitary: autoradiographic localization

Cited by 4 publications

References 31 publications

c-fos Expression in the forebrain and brainstem of White Leghorn hens following osmotic and cardiovascular challenges

c-fos Expression in the forebrain and brainstem of White Leghorn hens following osmotic and cardiovascular challenges

Angiotensin II Receptor Content Within the Circumventricular Organs Increases After Experimental Hydrocephalus in Rats

Atypical angiotensin receptors may mediate water intake induced by central injections of angiotensin II and of serotonin in pigeons

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