“…Early experiments demonstrated that Src, Fyn or Yes could be activated by a host of GPCRs, including the lysophosphatidic acid (LPA), a2A adrenergic, M1 muscarinic, M2 muscarinic, a-thrombin, endothelin, angiotensin II, bombesin, bradykinin, and V2 vasopressin receptors (Simonson and Herman, 1993;Chen et al, 1994;Ishida et al, 1995;Kramer et al, 1995;Linseman et al, 1995;Ptasznik et al, 1995;Luttrell et al, 1996;Rodriguez-Fernandez and Rozengurt, 1996;Schieffer et al, 1996;Simonson et al, 1996). From the outset, there was evidence for heterogeneity in the mechanisms underlying GPCR control of Src activity.…”