Angiotensin I, II, and III in sheep. A model of angiotensin production and metabolism.

Fei, D T; Scoggins, Bruce A.; Tregear, G. W.; Jp, Coghlan

doi:10.1161/01.hyp.3.6.730

Cited by 40 publications

(13 citation statements)

References 27 publications

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“…Both angiotensin I and angiotensin II are present in venous blood in concentrations far too high to be explained by their generation in the blood alone, especially given the extensive conversion of angiotensin I to angiotensin II and the clearance of both peptides across peripheral tissues [29]. This has led to the proposal that tissue angiotensin production contributes to angiotensin concentrations in plasma [29,30]. Several studies have suggested that vascular tissue can release angiotensin peptides into plasma by mechanisms independant of renal renin release [31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Lack of correlation between the acute haemodynamic response to intravenous captopril and plasma concentrations of angiotensin II in patients with chronic cardiac failure

Flapan

Shaw

Edwards

et al. 1992

Eur J Clin Pharmacol

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We have given a series of incremental intravenous injections of captopril to ten patients with chronic cardiac failure. Small doses of captopril produced significant changes in pulmonary artery end-diastolic pressure and right atrial pressure, up to a total cumulative dose of captopril of 2.5 mg, after which further injections had no significant effect. There were large changes in systemic vascular resistance and blood pressure up to a cumulative dose of captopril of 5.0 mg, after which the injection of larger doses caused no further significant changes. Small doses of intravenous captopril produced large increases in plasma renin activity and plasma angiotensin I concentrations up to a total cumulative dose of captopril of 1.25 mg, after which there were no significant further changes in either plasma renin activity or plasma angiotensin I concentration. However the plasma concentration of angiotensin II fell more slowly, no further change being recorded after a total cumulative dose of captopril of 10 mg. These results suggest that plasma renin activity is not the only determinant of plasma angiotensin II concentrations.

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Section: Discussionmentioning

confidence: 99%

Lack of correlation between the acute haemodynamic response to intravenous captopril and plasma concentrations of angiotensin II in patients with chronic cardiac failure

Flapan

Shaw

Edwards

et al. 1992

Eur J Clin Pharmacol

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“…First, a number of groups have shown the generation of both angiotensin I and II by isolated vascular preparations, notably the hind quarter of the rat [3-6]. Second, a few studies have care fully analysed the metabolism and produc tion of angiotensin I across various vascular beds in vivo and shown that a large turnover in angiotensin I occurs across many vascular beds with local generation replacing that taken up from the circulation [1,7,8]. Thus, considerable data now indicate that local production of both angiotensin I and II oc curs in the vascular wall.…”

Section: Introductionmentioning

confidence: 99%

Molecular Biology of the Vascular Renin-Angiotensin System

Samani

Swales²

1991

J Vasc Res

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Considerable evidence has been accumulated for a renin-angiotensin system in the blood vessel wall with local generation of both angiotensin I and angiotensin II that plays an important role in blood pressure regulation. A major source for vascular renin is renal renin taken up by the arterial wall from the circulation. However, recent studies suggest that, in addition, local synthesis of components of the renin-angiotensin cascade also takes place in the vessel wall. The contribution that these locally derived components make to the functions of the vascular renin-angiotensin system remains to be elucidated. Studies, particularly in vitro, suggest that vascular pathways for angiotensin generation not involving renin or angiotensin-converting enzyme may also exist. As in the case of the locally derived components of the renin-angiotensin cascade, the role of these alternate pathways in the physiology of the vascular wall remain to be defined.

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“…Evidence for the direct adsorption of renin in plasma and its loss upon bilateral nephrectomy has been dem onstrated [13]. The importance of vascular wall renin has been recognized by comparing the rate of clearance of angiotensins in var ious organs and the rate of production of angiotensins by the plasma renin system by the classical endocrine mechanism [14][15][16], The plasma renin activity was found to be insufficient for maintaining the plasma level of angiotensins which are cleared rapidly during passage through various organs. Thus, the importance of vascular wall renin had to be invoked.…”

Section: Introductionmentioning

confidence: 99%

Role of Vascular Wall Renin: Intracellular and Extracellular Mechanism

Inagami

Murakami²,

Higuchi³

1991

J Vasc Res

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Inhibitors of angiotensin-converting enzyme, renin and angiotensin II receptor lower the blood pressure of spontaneously hypertensive rats (SHRs) used as a model of essential hypertension. Since their plasma renin levels were normal or subnormal, renin in the vascular tissue was considered to play a key role in the maintenance of the hypertension. To clarify the source and localization of vascular renin in SHRs, the effects on blood pressure of antirenin antibodies, the converting enzyme inhibitors delapril and enalapril, and the angiotensin II receptor antagonist DuP 753 were examined in intact and bilaterally nephrectomized SHRs and their normotensive controls. The efficient hypotensive action of the renin antibody indicated that renin of the renal origin is a dominant factor. The gradual but complete disappearance of the antihypertensive action of these inhibitors of the renin-angiotensin system upon bilateral nephrectomy indicated the importance of membrane-associated renin of the renal origin and angiotensin-converting enzyme in the maintenance of the spontaneous hypertension.

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Angiotensin I, II, and III in sheep. A model of angiotensin production and metabolism.

Abstract: SUMMARY The arterial and centra] venous concentrations of angiotensin I (AI), Val'-anglotensln II ([Val' 3-8)), both peptides could be found in arterial blood. 1 The calculated blood clearance rates of these two smaller fragments of angiotensin were

Cited by 40 publications

References 27 publications

Lack of correlation between the acute haemodynamic response to intravenous captopril and plasma concentrations of angiotensin II in patients with chronic cardiac failure

Lack of correlation between the acute haemodynamic response to intravenous captopril and plasma concentrations of angiotensin II in patients with chronic cardiac failure

Molecular Biology of the Vascular Renin-Angiotensin System

Role of Vascular Wall Renin: Intracellular and Extracellular Mechanism

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