Angiotensin I-converting enzyme inhibitory peptides from an enzymatic hydrolysate of flounder fish (Paralichthys olivaceus) muscle as a potent anti-hypertensive agent

In silico analysis and antihypertensive effect of ACE-inhibitory peptides from smooth-hound viscera protein hydrolysate: Enzyme-peptide interaction study using molecular docking simulation

“…In addition, Jimsheena and Gowda [57] described that arachin ACE-inhibitory peptides did not directly coordinate with the Zn(II) atom, but, their interaction with His383, His387 and Glu411 promoted their inhibitory activity. In contrast, Ko et al [7] studies have shown that MEVFVP, a competitive ACE inhibitor peptide, could bind the enzymatic active site through a metal ion interaction (Zn701), H-bond interactions including Glu411, Arg522, Asn66, and a Pi interaction bond via the Tyr523. Non-competitive ACE inhibitors able to interact to ACE leading to its conformational change, have been frequently reported [56,58].…”

Isolation and identification of the angiotensin-I converting enzyme (ACE) inhibitory peptides derived from cottonseed protein: optimization of hydrolysis conditions

“…Since then, many other ACE inhibitory peptides have been produced from enzymatic hydrolysates of different food proteins, such as casein, whey protein, mushroom, walnuts meal, wheat protein, fish protein, soybean protein, rapeseed protein, and marine organisms protein etc. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Cottonseed protein is the second-best potential source of plant proteins. [22] Six proteases including flavourzyme, neutrase, alcalase, papain, pepsin, and trypsin have been used to digest cottonseed protein for the production of ACE inhibitory peptides.…”

Angiotensin I‐converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle

“…In fact, the use of muscle protein derived from meat, fish or invertebrates to contribute with ACE inhibitory peptides to the diet has been of great interest during the last years. There are some recent published studies of ACE inhibitory peptides identified in fish muscle protein such as flounder fish and tilapia (Huang et al, 2015;Ko et al, 2016).…”