Angiotensin I-converting enzyme inhibitory peptides in red-mold rice made by Monascus purpureus

Kuba, Megumi; Tanaka, Kumi; Sesoko, Masayasu; Inoue, Fumiyuki; Yasuda, Masaaki

doi:10.1016/j.procbio.2009.06.007

Cited by 31 publications

(31 citation statements)

References 26 publications

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“…Peptides identified in all the fractions were compared with the published amino acid sequence of active peptides to determine the bioactive and sensory-active peptides and then were listed in Table III, according to the increasing order of M + H + . Most of these have previously demonstrated ACE-inhibitory activity and some such as LSP, YG, YW, LQP, PLGPP, completely or partly matched the identified peptides in this experiment 3,13,20,31,33,36,37 . As antioxidative peptides, they also completely or partly matched with published amino acid sequence of peptides, 20,31 .…”

Section: Potential Activity Of the Peptidessupporting

confidence: 79%

“…It has been reported that rice wine or its raw materials (rice and wheat) have antioxidative 27,38 , antihypertensive 12,13 , hypocholesterolemic 29 , and antimicrobial 8 properties because of the γ-amino butyric acid, phenols, peptides and other compounds.…”

Section: Identification Of Low Molecular Weight Peptides In Chinese Rmentioning

confidence: 99%

“…The antioxidative peptides and ACE (Angiotensin Iconverting enzyme)-active peptides in various types of foods have been studied and show the ability to eradicate free radicals and to alleviate hypertension 13,30,31 .…”

Section: Identification Of Low Molecular Weight Peptides In Chinese Rmentioning

confidence: 99%

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Identification of Low Molecular Weight Peptides in Chinese Rice Wine (Huang Jiu) by UPLC-ESI-MS/MS

Han

2011

Journal of the Institute of Brewing

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The aim of this work was to increase the general knowledge of peptide identification and to examine the low molecular weight peptides in Chinese rice wine (Huang Jiu) as there are very few publications in the literature on this topic. Chinese rice wine (Huang Jiu) has a high content of peptides and more than 500 peptides have been tentatively identified by ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-MS/MS), including 43 potential bioactive peptides and 3 sensory-active peptides, based on published references to date. These peptides have been tentatively identified according to the MS/MS spectra which produced sufficient information of product ions (complementary y ions and b ions). Results from this work indicated that it is feasible to produce rice wine with rich bioactive peptides and that there is potential to examine for rice wine authenticity and traceability based on the origin of the peptides.

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Section: Potential Activity Of the Peptidessupporting

confidence: 79%

Section: Identification Of Low Molecular Weight Peptides In Chinese Rmentioning

confidence: 99%

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Identification of Low Molecular Weight Peptides in Chinese Rice Wine (Huang Jiu) by UPLC-ESI-MS/MS

Han

2011

Journal of the Institute of Brewing

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“…However, this method is time consuming and requires highly purified samples (free of salts, detergents, and nonvolatile additives such as urea). Edman degradation can be performed manually or it can be fully automated using special automated protein/peptide sequencers (Gouda et al, 2006;Lee et al, 2006aLee et al, , 2006bPapadimitriou et al, 2007;Kuba et al, 2009;Rho et al, 2009).…”

Section: Identification and Characterization Of Bioactive Peptides Frmentioning

confidence: 99%

“…A combination of trypsin-chymotrypsin (Rizzello et al, 2008), pepsin-pancreatin (Robert et al, 2004), pepsin-corolase PP (Quiros et al, 2005), pepsin-trypsin (Koo et al, 2006) or pepsin-trypsin-protease N (Hyoung et al, 2004) enzymes have been employed for this purpose. This procedure has been assayed with peptides isolated from sea cucumber (Zhao et al, 2009), rice (Kuba et al, 2009), oyster (Wang et al, 2008a), porcine hemoglobin , and wakame (Sato et al, 2002) hydrolysates. Resistance to intestinal digestion can also be demonstrated by the use of a model system such as Caco-2 cells.…”

Section: Identification and Characterization Of Bioactive Peptides Frmentioning

confidence: 99%

Isolation and Characterization of Peptides with Antihypertensive Activity in Foodstuffs

Puchalska

Marina

García

2014

Critical Reviews in Food Science and Nutrition

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Hypertension is one of the main causes of cardiovascular diseases. Synthetic drugs inhibiting ACE activity present high effectiveness in the treatment of hypertension but cause undesirable side effects. Unlike these synthetic drugs, antihypertensive peptides do not show any adverse effect. These peptides are naturally present in some foods and since hypertension is closely related to modern diet habits, the interest for this kind of foods is increasing. Different methods for the purification, isolation, and characterization of antihypertensive peptides in foods have been developed. Nevertheless, there is no revision work summarizing and comparing these strategies. In this review, in vivo and in vitro pathways to obtain antihypertensive peptides have been summarized. The ACE mechanism and the methodologies developed to assay the ACE inhibitory activity have also been described. Moreover, a comprehensive overview on the isolation, purification, and identification techniques focusing on the discovery of new antihypertensive peptides with high activity has been included. Finally, it is worthy to highlight that the quantitation of antihypertensive peptides in foods is a new trend since genotype and processing conditions could affect their presence. Analytical methodologies using mass spectrometry constitute an interesting option for this purpose.

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Bioactive Proteins and Peptides from Microalgae

Stack

Gouic

Fitzgerald

2020

Encyclopedia of Marine Biotechnology

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Angiotensin I-converting enzyme inhibitory peptides in red-mold rice made by Monascus purpureus

Cited by 31 publications

References 26 publications

Identification of Low Molecular Weight Peptides in Chinese Rice Wine (Huang Jiu) by UPLC-ESI-MS/MS

Identification of Low Molecular Weight Peptides in Chinese Rice Wine (Huang Jiu) by UPLC-ESI-MS/MS

Isolation and Characterization of Peptides with Antihypertensive Activity in Foodstuffs

Bioactive Proteins and Peptides from Microalgae

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