Angiotensin‐I‐converting enzyme <i>insertion/deletion</i> polymorphism and high urinary albumin concentration in French Type 2 diabetes patients

Hadjadj, Samy; Gallois, Yves; Alhenc-Gelas, F; Châtellier, Gilles; Marre, Michel

doi:10.1046/j.1464-5491.2003.01024.x

Cited by 24 publications

(13 citation statements)

References 30 publications

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“…Thus, we segregated to male and female populations and the DD genotype was found to be the major risk determinants of CKD among female (OR = 2.40) population. This result was also supported by previous results from France [27] and Mexican population [26]. Furthermore, recently our group [28] reported that female is more prone to hypertension after menopause in Tamilnadu population.…”

Section: Discussionsupporting

confidence: 90%

ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population

Nagamani

Perumal

Perumal³

et al. 2015

Egyptian Journal of Medical Human Genetics

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Background: The Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1).Aim: To investigate the association of ACE I/D polymorphism and Chronic Kidney Disease (CKD) in south India.Methods: In the present study, we have collected CKD patients (n = 147) and control subjects (n = 211) from Tamilnadu. Genotyping was carried out by polymerase chain reaction (PCR) on the basis of allele specific primers.Results: The DD genotype is associated with the female population (OR-CI = 2.40 (1.05-5.51), p = 0.04) as compared to the male population (OR-CI = 0.75 (0.37-1.51), p = 0.42). Further, we found the over representation of ''I'' -allele (homozygous II and heterozygous ID) in unaffected males [OR (CI) -0.58 (0.32-1.04), p = 0.07] which suggests its protective role in male population.Conclusion: The DD genotype of ACE is associated with CKD in south India.Ó 2014 Production and hosting by Elsevier B.V. on behalf of Ain Shams University.

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Section: Discussionsupporting

confidence: 90%

ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population

Nagamani

Perumal

Perumal³

et al. 2015

Egyptian Journal of Medical Human Genetics

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“…Thus, the contribution of ACE gene polymorphism to the heritable part of risk for diabetic nephropathy seems important, and is supported by findings from published meta-analyses [28,62] along with other studies done among Indians [31,63], Japanese [29], French [64], Egyptian [65] and Taiwan [27] diabetic patients. However, our results do not coincide with studies done among Chinese [66], Tunisian [55], French [56], Turkish [34] and Iranian [67] diabetic cases. This discrepancy in polymorphisms association studies may be reconciled by several factors, with ethnic/racial and geographic differences being a potential reason i.e.…”

Section: Discussioncontrasting

confidence: 99%

“…Therefore, we suggest that the genetic variation at the ACE locus as D/D variant in intron 16, contribute to an increased risk of nephropathy in T2DM patients, but not extent of DN severity (as the allelic or genotypic distribution was comparable between the two DN groups) in studied population. Our findings were in conformity with other studies [26][27][28][29][30][31] but not all [32,55,56]. This difference may possibly be due to different races, methods of quantitation and patient selection; as proteinuria in adults is a multifactorial condition frequently linked with diabetes, the issue of whether proteinuria is due to diabetes or some other etiology remains debatable, but there was no uncertainty in our group of patients on the role of T2DM in diabetic nephropathy constitution as we excluded the patients who had proteinuria/renal disorders before their diabetes was diagnosed, thus we confined our study to diabetic kidney diseases.…”

Section: Discussionsupporting

confidence: 94%

Genetic Predisposition to Diabetic Nephropathy: Evidence for a Role of ACE (I/D) Gene Polymorphism in Type 2 Diabetic Population from Kutch Region

et al. 2013

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Genetic polymorphism as described with angiotensin-converting enzyme gene has been proposed as a putative mediator of diabetic nephropathy. We substantiate the hypothesis that genetic variants of the ACE have significant impacts on diabetic nephropathy. To assess the possible association between the three ACE polymorphic variants and DN in an ethnically homogeneous type 2 diabetic population from Kutch region. A 287-bp insertion/deletion polymorphism in intron 16 of the ACE gene was examined by polymerase chain reaction using a case-control approach conducted with 309 unrelated type 2 diabetic patients of Kutch origin (159 Ahir and 150 Rabari, with [10 years duration of T2DM). Of the patients, 143 had nephropathy {AER[30 mg/day (Ahir, n:73 and Rabari, n:70)} and were considered as cases; all others {n:166 (86 Ahir and 80 Rabari)} were normoalbuminuric (AER\30 mg/day) and were treated as controls. Suitable descriptive statistics was used for different variables. Genotype frequencies in all groups were all in accordance with the Hardy-Weinberg equilibrium. Genotypic distribution was significantly different between cases and controls (Ahir: x 2 :8.87, 2 d.f. p = 0.0118; Rabari: x 2 :11.01, 2 d.f. p = 0.0041). Multivariate logistic regression analysis revealed that DD genotype was a significant and strongest independent predictor of microalbuminuria (Ahir: p = 0.0362, OR = 2.65, 95 % CI 1.89-6.36; Rabari: p = 0.024, OR = 2.81, 95 % CI 1.9-6.65). However, it did not independently change the odds of having macroalbuminuria versus microalbuminuria. Analysis of the association under various genetic models revealed that ACE I/D polymorphic variant contribute to DN susceptibility under recessive mode only. Genetic variation at the ACE locus as D/D variant in intron 16, contribute to an increased risk of nephropathy in T2DM patients but not extent of DN severity, and thus this polymorphism might be considered as genetic risk factors for DN among patients with type 2 diabetes.

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“…The conclusions of individual association studies of the I/D ACE polymorphism and nephropathy syndrome differ due to different ethnic background [4] and different dietary habits. The minor D allele was not associated with type 2 diabetic nephropathy in a European population [7,[58][59][60][61][62] and the results from our study confirmed this fact. On the contrary, the association was proven for type 2 diabetic patients from an Asian population [31,[63][64][65][66][67][68][69][70] with the exception of four studies [71][72][73][74].…”

Section: Discussionsupporting

confidence: 82%

Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

et al. 2012

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A considerable variability in the incidence and prevalence of diabetic nephropathy (DN) coheres with an important contribution of multigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transporter 1 gene, the G/T (894) polymorphism and the T/C (−786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism in the eNOS gene is associated with metabolic syndrome including type 2 diabetes.

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Angiotensin‐I‐converting enzyme insertion/deletion polymorphism and high urinary albumin concentration in French Type 2 diabetes patients

Abstract: The ACE I/D polymorphism was not associated with high urinary albumin concentration in French Type 2 diabetes patients.

Cited by 24 publications

References 30 publications

ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population

ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population

Genetic Predisposition to Diabetic Nephropathy: Evidence for a Role of ACE (I/D) Gene Polymorphism in Type 2 Diabetic Population from Kutch Region

Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

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