Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity of Ursolic Acid Isolated from Thymus vulgaris, L.

Shimada, Atsumi; Inagaki, Michio

doi:10.3136/fstr.20.711

Cited by 15 publications

(5 citation statements)

References 23 publications

(26 reference statements)

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“…Further research has been carried out in various directions. Vasorelaxant properties of ursolic acid were investigated by Aguirre-Crespo et al [130], Rios et al [131] and Shimada and Inagaki [132]. The first two teams connected the activity of UA with the production and release of nitric oxide (NO) in isolated thoracic aorta and in vivo on Wistar rats, respectively.…”

Section: Impact Of Ursolic Acid On Condition and Functioning Of Bomentioning

confidence: 99%

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

2015

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Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties. In this review the current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are presented. Particular attention has been paid to the application of ursolic acid as an anti-cancer agent; it is worth noticing that clinical tests suggesting the possibility of practical use of UA have already been conducted. Amongst other pharmacological properties of UA one can mention protective effect on lungs, kidneys, liver and brain, anti-inflammatory properties, anabolic effects on skeletal muscles and the ability to suppress bone density loss leading to osteoporosis. Ursolic acid also exhibits anti-microbial features against numerous strains of bacteria, HIV and HCV viruses and Plasmodium protozoa causing malaria.

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Section: Impact Of Ursolic Acid On Condition and Functioning Of Bomentioning

confidence: 99%

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

2015

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“…It was discovered that UA reduced genetically hypertensive rat heart rates by 32%. Shimada and Inagaki 73,74 looked into UA's vasorelaxant properties, targeted at the inhibitory action of the angiotensin I‐converting enzyme, which is crucial for blood pressure regulation. Also, isoproterenol injection has been used to cause myocardial infarction artificially, whereas UA was being utilised as a molecule with potent inhibitory action.…”

Section: Therapeutic Potential Of Uamentioning

confidence: 99%

Therapeutic potential and novel formulations of ursolic acid and its derivatives: an updated review

Namdeo

Gidwani²,

Tiwari

et al. 2023

J Sci Food Agric

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Plants produce biologically active metabolites that have been utilised to cure a variety of severe and persistent illnesses. There is a possibility that understanding how these bioactive molecules work would allow researchers to come up with better treatments for diseases including malignancy, cardiac disease and neurological disorders. A triterpene called ursolic acid (UA) is a pentacyclic prevalent triterpenoid found in fruits, leaves, herbs and blooms. The biological and chemical aspects of UA, as well as their presence, plant sources and biosynthesis, and traditional and newer technologies of extraction, are discussed in this review. Because of its biological function in the creation of new therapeutic techniques, UA is a feasible option for the evolution and medical management of a wide range of medical conditions, including cancer and other life threatening diseases. Despite this, the substance's poor solubility in aquatic environments makes it unsuitable for medicinal purposes. This hurdle was resolved in many different ways. The inclusion of UA into various pharmaceutical delivery approaches was found to be quite effective in this respect. This review also describes the properties of UA and its pharmacokinetics, as well as therapeutic applications of UA for cancer, inflammatory and cardiovascular diseases, in addition to its anti‐diabetic, immunomodulatory, hepatoprotective and anti‐microbial properties. Some of the recent findings related to novel nano‐sized carriers as a delivery system for UA and the patents related to the applications of UA and its various derivatives are covered in this review. The analytical study of UA, oleanolic acid and other phytoconstituents by UV, HPLC, high‐performance thin‐layer chromatography and gas chromatography is also discussed. In the future, UA could be explored in vivo using various animal models and, in addition, the regulatory status regarding UA needs to be explored. © 2023 Society of Chemical Industry.

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“…The potential effect of ursolic acid analogues on the heart had been demonstrated by several investigators. For instance, Somova, et al, (2003) showed ursolic acid to be able to lower the heart rate of genetically hypertensive rats by 32% and also ursolic acid had been shown to have protective effect on the cardiovascular systems ( [16], [17]) as well as inhibiting the activity of angiotensin converting enzymes [18]. Esculentoside (compound 4), an imidazole pyridine analogue showed positive inotropic and positive chronotropic effect on the animal.…”

Section: Cardiotonic Activities Of a Esculentus Fruit Extract And Its...mentioning

confidence: 99%

Electrocardiography effects of Abelmoschus esculentus fruit extract and its isolated compounds using isolated frog heart perfusion

Kehinde¹,

Olatunji²,

Adegoke³

2022

World J. Adv. Res. Rev.

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This study evaluated the electrocardiograph effects of Abelmoschus esculentus and its isolated compounds on Rana temporaria (frog) heart. Cardiovascular disease is one of the major causes of mortality which contribute to about 57 million deaths as disclosed by WHO in 2002. There have been many therapeutic approaches to reduce the death rate from cardiovascular disease which include the use of herbal drugs from plants. The whole fruit of Abelmoschus esculentus (Okra) fruit has been used for culinary purposes in Africa. Medicinal properties of Abelmoschus esculentus reported in literature include its use as anti-diabetics, antimicrobial, diuretic agent, and for plasma replacement. However, there have been little or no report on the cardiovascular activities of the extract or isolated compounds from A. esculentus. A. esculentus (Okra) fruits were collected, identified, dried, and powdered. The powdered was extracted using cold maceration with 100% methanol for 72 hours. The crude extract was subjected to repeated fractionation to isolate four (4) compounds. The cardiovascular activities of the crude extract and its isolated compounds were investigated using isolated heart perfusion technique on Rana temporaria (frog) heart. The effects of the extract and isolated compounds on the rate (frequency) and force of contraction (amplitude) of the heart beat were evaluated. The isolated compounds were subjected to spectroscopic analysis using ultraviolent (UV), nuclear magnetic resonance (NMR) (1D and 2D experiments), and mass spectrometry. The compounds were elucidated as quercetin glycoside, quercetin diglycoside, urs-12-ene-3-O-β-D-glucopyranoside and 3-hydroxy-2,3-dihydroimidazo [1,5-a] pyridin-8(5H)-one-5-β-glucopyranoside (esculentoside). The extract and the isolated compounds showed positive inotropic effect on the heart (increase in amplitude of the heart) while they all also possess negative chronotropic effect (decrease in frequency) except compound 4 which possess positive chronotropic effect. This study isolated three different classes of compounds from A. esculentus namely Flavonoids (Quercetin glycoside), Triterpene (Ursolic acid) and pyridine-imidazole (esculentoside). This study also demonstrated that A. esculentus extract and compounds isolated from it has negative chronotropic effects and also possess positive inotropic effects on the heart of R. temporaria.

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Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity of Ursolic Acid Isolated from Thymus vulgaris, L.

Cited by 15 publications

References 23 publications

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

Therapeutic potential and novel formulations of ursolic acid and its derivatives: an updated review

Electrocardiography effects of Abelmoschus esculentus fruit extract and its isolated compounds using isolated frog heart perfusion

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