Angiotensin I, angiotensin II and their biologically active peptides

Ferrario, Carlos M.

doi:10.1097/00004872-200205000-00004

Cited by 28 publications

(17 citation statements)

References 18 publications

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“…A possible beneficial effect could be induced by the direct renin inhibitor (DRI) drug, aliskiren, in relation to vascular reactivity in cases of hypercholesterolemia and associated oxidative stress. Yet, it is not well defined if the vascular protection induced by drugs acting on RAAS is due to the resulting inhibition of Ang II production, the inhibition of the effect of Ang II on Angiotensin receptors type 2 (AT2) or the accompanied availability of other bioactive angiotensin peptides as Ang III, Ang IV, and Ang1-7 that affect receptors other than Angiotensin receptors type 1 (AT1) [4][5][6]. Pharmacological researches, done on aliskiren, could provide suggested evidence about its possible action on different types of angiotensin in the pathogenesis of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Aliskiren Protects against Hypercholesterolemia and Oxidative Stress on Isolated Aortae in Cholesterol-Fed Rats

Kamal¹

2011

J Nanomedic Nanotechnol

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Background: Atherosclerosis and endothelial dysfunction are important associated disorders in the majority of hypertensive patients. Many studies are directed towards investigating any possible anti-hyperlipidemic effect with improvement of arterial compliance of newer generations of antihypertensive drugs so as to reduce the number of drugs used to treat those patients. Aim:The present study aims to determine the effects of aliskiren, a direct renin inhibitor, on serum cholesterol and some anti-oxidant enzymes together with aortic TBARS and vasorelaxant effect of acetyl-choline (Ach) on isolated aortic rings of cholesterol-fed rats. Methods:The duration of the study was 12 weeks. Twenty-four rats were randomly divided into 3 groups (n=8 rats/ group). Group (1) is control, received 0.5% carboxymethylcellulose (CMC) sodium, as a solvent of aliskiren, and fed ordinary diet. Group (2) fed 2% (w/w) cholesterol diet + CMC sodium. Group (3) was fed with 2% (w/w) cholesterol diet with ip daily administration of aliskiren at a dose of 5 mg/kg for 12 weeks. Systolic blood pressure (SBP) was assessed both at the beginning and at the end of every 4 weeks of the study. Serum total cholesterol, superoxide dismutase (SOD) enzyme in erythrocyte lysates, thiobarbituric acid reactive substance [TBARS] content, activities of catalase and glutathione enzymes in aortic homogenates of tested rats were measured. The thoracic aortae were removed from all tested rats to assess the vasorelaxant effect of Ach.Results: Aliskiren-treated group (3) showed a significant improvement of all the markers in comparison with nontreated cholesterol-fed rats. SBP of treated group was maintained at levels comparable to control group (1) with marked improvement in aortic reactivity to ACh compared to group (2). Conclusion:Aliskiren could possess an anti-hypercholestrolemic and an ability to improve aortic reactivity via an anti-oxidant effect and a reduction in lipid peroxidation in cholesterol-fed rats.

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Section: Introductionmentioning

confidence: 99%

Aliskiren Protects against Hypercholesterolemia and Oxidative Stress on Isolated Aortae in Cholesterol-Fed Rats

Kamal¹

2011

J Nanomedic Nanotechnol

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“…Angiotensin (Ang) II and other active peptides of the reninangiotensin system, such as Ang IV [Ang- (3)(4)(5)(6)(7)(8)] and Ang- (1)(2)(3)(4)(5)(6)(7), are mostly known as regulators in the cardiovascular system. 1 However, recent studies have shown that AngII and Ang-(1-7) also have regulatory effect on tissue regeneration, cellular proliferation and growth factor release.…”

Section: Introductionmentioning

confidence: 99%

“…1 However, recent studies have shown that AngII and Ang-(1-7) also have regulatory effect on tissue regeneration, cellular proliferation and growth factor release. 2,3 In vivo studies have shown that AngII and Ang-(1-7) increased hematopoietic recovery after myelosuppression and progenitor engraftment.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

Heringer-Walther¹,

Eckert²,

Schumacher³

et al. 2009

Haematologica

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“…Besides AngII, other Ang peptides, such as AngIV [Ang-(3-8)] and Ang-(1-7) may also have important biological activities (Figure 1). 124 In vascular smooth muscle cells, Ang IV binds to the AT4 receptor, activates NF-κB and increases MCP-1. 125 In the kidney Ang-(1-7) has AT1/AT2-independent inflammatory properties: it binds to the Mas receptor, activates NF-κB and promotes the secretion of NF-κB-dependent proinflammatory molecules.…”

Section: Renin-angiotensin System (Ras)mentioning

confidence: 99%

Obstructive renal injury: from fluid mechanics to molecular cell biology

ORTIZ¹

2010

OAJU

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Urinary tract obstruction is a frequent cause of renal impairment. The physiopathology of obstructive nephropathy has long been viewed as a mere mechanical problem. However, recent advances in cell and systems biology have disclosed a complex physiopathology involving a high number of molecular mediators of injury that lead to cellular processes of apoptotic cell death, cell injury leading to inflammation and resultant fibrosis. Functional studies in animal models of ureteral obstruction using a variety of techniques that include genetically modified animals have disclosed an important role for the renin-angiotensin system, transforming growth factor-β1 (TGF-β1) and other mediators of inflammation in this process. In addition, high throughput techniques such as proteomics and transcriptomics have identified potential biomarkers that may guide clinical decision-making.

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Angiotensin I, angiotensin II and their biologically active peptides

Cited by 28 publications

References 18 publications

Aliskiren Protects against Hypercholesterolemia and Oxidative Stress on Isolated Aortae in Cholesterol-Fed Rats

Aliskiren Protects against Hypercholesterolemia and Oxidative Stress on Isolated Aortae in Cholesterol-Fed Rats

Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

Obstructive renal injury: from fluid mechanics to molecular cell biology

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