Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Polyneuropathy in Type 2 Diabetes without Macroalbuminuria

Abstract

Angiotensin-converting enzyme (ACE) gene polymorphism is thought to be a potent risk

Angiotensin‐converting enzyme (ACE) gene II genotype protects against the development of diabetic peripheral neuropathy in type 2 diabetes mellitus

“…It is a consequence of metabolic disturbances caused by diabetes mellitus, which, in turn, is affected by both environmental and genetic factors. An association has been reported for the ACE I/D polymorphism and metabolic disorders, such as obesity, 19 T2DM, and complications of T2DM, including neuropathy and nephropathy 11,17,20–24 . The results of the present study suggest an association between the ACE I/D variant and microvascular complications (i.e.…”

“…It is possible that other sugars also accumulate in nerve tissue as a consequence of excess glucose metabolism in nerve tissue. The resulting hyperosmolarity causes swelling of the nerve tissue, slowing of nerve conduction, and degeneration of the myelin sheath 11 …”

Genotypic interactions of renin–angiotensin system genes with diabetes type 2 in a Tunisian population

“…Based on previous studies, we chose as risk alleles the D allele for ACE I/D (Ito et al 2002), the T allele for AGT M235T (Brenner et al 2005), and the C allele for AT1R A1166C (Tiret et al 1994) polymorphism in the RAS pathway.…”

Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis

“…Several studies have investigated this issue to date. [13][14][15][16][17][18][19] The results, however, were inconsistent and conflicting. This present metaanalysis was performed to evaluate the association between this polymorphism and DPN.…”