Angiotensin-Converting Enzyme Inhibitors Slow Recovery From Anemia Following Cardiac Surgery

Ripamonti, Vittorino; Racca, Vittorio; Calvo, Maria Gaetana; Castiglioni, Paolo; Ferratini, Maurizio

doi:10.1378/chest.130.1.79

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…Moreover, a small Italian study showed that enalapril slowed postoperative recovery of Hb levels when given early after CABG 20. In our analysis, the early initiation of quinapril after CABG slowed recovery of Hb levels and was also associated with early cardiovascular events.…”

Section: Discussionmentioning

confidence: 53%

Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial

Westenbrink

Kleijn

Boer

et al. 2011

Heart

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Section: Discussionmentioning

confidence: 53%

Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial

Westenbrink

Kleijn

Boer

et al. 2011

Heart

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“…reported that enalapril resulted in a 56% increase in the development of de novo anemia within the first year of treatment. On the other hand, early postoperative reintroduction of ACEI slows recovery from anemia following CS 37 . However, as inhibition of the stimulatory effects of angiotensin II on erythropoietin secretion is one of the mechanisms through which ACEI/ARAII may impair erythropoiesis, 24,38 administration of recombinant erythropoietin might be useful for treating this anemia.…”

Section: Discussionmentioning

confidence: 99%

Preoperative anemia in elective cardiac surgery: prevalence, risk factors, and influence on postoperative outcome

Múñoz

Ariza²,

Gómez‐Ramírez

et al. 2010

Transfusion Alternatives in Transfusion Medicine

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Keywords• allogeneic blood transfusion • cardiac surgery • postoperative outcome • preoperative anemia S U M M A R YPreoperative anemia in patients undergoing cardiac surgery is associated with a higher transfusion risk and poorer outcomes. This retrospective study was undertaken to assess the prevalence of preoperative anemia and its associated risk factors, as well as its influence on postoperative outcomes, in 576 patients undergoing elective cardiac surgery (52.3% with cardiopulmonary bypass) for myocardial revascularization, valve replacement, coronary + valve, or miscellaneous pathology at a single institution. Perioperative data were reviewed according to the presence or absence of preoperative anemia (hemoglobin < 13 g/dL for men, hemoglobin < 12 g/dL for women). Overall, 210 patients (36.5%) presented with anemia. Logistic regression analysis revealed that age, chronic kidney disease, and consumption of proton pump inhibitors histamine H 2 receptor antagonists and diuretics were independent risk factors for the presence of preoperative anemia. Postoperatively, anemic patients received transfusions and inotropic support and stayed longer than 4 days in the recovery unit more frequently than non-anemic patients, but there were no differences in the composite outcome variable (stroke, myocardial infarction, renal failure or death). In conclusion, our data seem to indicate that preoperative anemia has a high prevalence among elective cardiac surgical patients and increases postoperative morbidity. Therefore, we need to address two specific areas about preoperative anemia in these patients: early recognition and evaluation, and appropriate and timely treatment.

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“…To our knowledge, the impact of ACE-I and ARB use on inhibition of the positive hematologic effects of renin-angiotensin system activation has been studied thoroughly only in patient populations at risk for secondary erythrocytosis [5][6][7][8][9][10][11] but not in most patients taking these pharmaceuticals for indications such as diabetes, hypertension, IHD, and left ventricular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Association of Angiotensin-Converting Enzyme Inhibitor Therapy Initiation With a Reduction in Hemoglobin Levels in Patients Without Renal Failure

Leshem

Steinvil

Zeltser

et al. 2012

Mayo Clinic Proceedings

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Angiotensin-Converting Enzyme Inhibitors Slow Recovery From Anemia Following Cardiac Surgery

Cited by 12 publications

References 20 publications

Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial

Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial

Preoperative anemia in elective cardiac surgery: prevalence, risk factors, and influence on postoperative outcome

Association of Angiotensin-Converting Enzyme Inhibitor Therapy Initiation With a Reduction in Hemoglobin Levels in Patients Without Renal Failure

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