Angiotensin-converting enzyme inhibitors during the first trimester of pregnancy increase the incidence of fetal malformation, whereas calcium intake (1.0 to 2.0 g/day) prevents preeclampsia
Abstract:A retrospective study on 29,507 pregnant women published in the New England Journal of Medicine in June 2006 showed that the use of angiotensin-converting enzyme (ACE) inhibitors during the fi rst trimester of pregnancy increased the risk of major fetal malformation. The estimated risk ratio was 2.71, with a 95% confi dence interval (CI) of 1.72-4.27, in comparison with patients who did not receive anti-hypertensive medication. Other hypertensive drugs utilized during the same period of pregnancy did not inc… Show more
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