Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit

Can’t Intubate, Can’t Oxygenate: A Rare Case of a Difficult Airway due to Nonhereditary Angioedema

“…Clinical features are often associated with elevated bradykinin levels, which lead to increased vascular permeability and the development of angioedema. ( 3 , 4 ) There is increasing data in the literature on the effectiveness of HAE treatment (not only type I and II, but also AAE) related to angioedema caused by drugs for the treatment of hypertension from the ACEI group, such as in the case of our patient. ( 3 , 5 , 6 ) The number of patients who are taking ACEI therapy to treat hypertension is on the rise.…”

“…( 3 , 4 ) There is increasing data in the literature on the effectiveness of HAE treatment (not only type I and II, but also AAE) related to angioedema caused by drugs for the treatment of hypertension from the ACEI group, such as in the case of our patient. ( 3 , 5 , 6 ) The number of patients who are taking ACEI therapy to treat hypertension is on the rise. Therefore, it is no surprise that that the number of different side effects has doubled in the last decade from 24% to 49%, which is explained by more regular reporting of side effects by doctors and higher awareness of possible side effects in patients.…”

“…( 1 ) Acquired angioedema can occur with various lymphoproliferative diseases, as well as with the use of therapeutic drugs for hypertension, especially from the group of ACE inhibitors, as in our case. ( 1 , 3 )…”

Early Health Technology Assessments in Pharmacogenomics: A Case Example in Cardiovascular Drugs

“…to calculate the fraction of ICU stays of per total inpatient stays [17]. ICU stays were further specified Early HTA in pharmacogenomics: a case example in cardiovascular drugs Research Article using data from Soo Hoo et al [28]. They investigated ACEi-induced angioedema requiring ICU admission, yielding data on hospitalization duration [28].…”

Determinants of angiotensin‐converting enzyme inhibitor (ACEI) intolerance and angioedema in the UK Clinical Practice Research Datalink

“…Angiotensin‐converting enzyme inhibitors (ACEIs) are among the most commonly prescribed antihypertensive agents to date used for hypertension, heart failure, diabetic nephropathy and secondary prevention following a myocardial infarction (MI). The estimated number of ACEI prescriptions has substantially increased over the past few years, from 35–40 million worldwide in 2001 to approximately 160 million in 2011 in the USA alone . In the UK, ramipril is the leading drug among medications for hypertension and heart failure, with almost 26 million prescriptions dispensed in 2014, which shows an increase of 17 million prescriptions since 2004 .…”