Angiotensin-Converting Enzyme Inhibition, Angiotensin, and Cognition

Barnes, James L.; Barnes, NM; Costall, B.; Coughlan, J.; Kelly, M. E.; Naylor, R.J.; Tomkins, D.M.; Williams, T J

doi:10.1097/00005344-199219006-00011

Cited by 65 publications

(36 citation statements)

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“…Experimental data on angiotensin-converting enzyme (ACE) inhibition are somewhat controversial. Barnes et al [90] reported that ACE inhibition can ameliorate learning performance in animal models. These authors attributed this beneficial effect at least in part to the removal of an inhibitory tone on central acetylcholine release, and/or an effect on central catecholaminergic function.…”

Section: The Effects Of Antihypertensive Treatment On Alzheimer Diseamentioning

confidence: 99%

Effects of Blood Pressure Changes on Alzheimer’s Disease

Feldstein¹

2010

Neuroepidemiology

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Alzheimer’s disease is the most frequent cause of dementia. Whereas other major causes of death have been decreasing, the number of deaths due to Alzheimer’s disease is rising. As there is no cure for this type of dementia at present, preventive measures have assumed great importance. By analyzing data from available longitudinal studies, the current review presents evidence supporting a link between Alzheimer’s disease and blood pressure changes.

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Section: The Effects Of Antihypertensive Treatment On Alzheimer Diseamentioning

confidence: 99%

Effects of Blood Pressure Changes on Alzheimer’s Disease

Feldstein¹

2010

Neuroepidemiology

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“…It constricts vascular smooth muscle, enhances the activity of the sympathetic nervous system and promotes aldosterone release from the adrenal gland [2]. In addition to effects on cardiovascular homeostasis, Ang II also contributes to the control of cellular growth [3][4][5]. Ang II can be further metabolized to several bioactive peptides, including Ang 1-7 (AspArg-Val-Tyr-Ile-His-Pro), Ang III (Arg-Val-Tyr-Ile-His-Pro-Phe) and Ang IV (Val-Tyr-IleHis-Pro-Phe).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous analysis of angiotensin peptides by LC–MS and LC–MS/MS: Metabolism by bovine adrenal endothelial cells

Cui

Nithipatikom

Campbell

2007

Analytical Biochemistry

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Liquid chromatography-electrospray ionization-mass spectrometry and liquid chromatographytandem mass spectrometry methods were developed to simultaneously determine the concentrations of angiotensin (Ang) II, Ang 1-7, Ang III and Ang IV in biological samples. The samples were extracted with C18 solid-phase extraction cartridges, and separated by a reverse-phase C18 column using acetonitrile in water with 0.1 % formic acid as a mobile phase. Angiotensin peptides were ionized by electrospray and detected by triple quadrupole mass spectrometry in the positive ion mode. (M+3H) 3+ and (M+2H) 2+ ions were chosen as the detected ions in the single ion recording (SIR) mode for LC-MS. The limits of detection (S/N=3) using SIR are 1 pg for Ang IV and 5 pg for Ang 1-7, Ang III and Ang II. Multiple reaction monitoring (MRM) mode was used for LC-MS/MS. The limits of detection (S/N=3) using MRM are 20 pg for Ang IV and 25 pg for Ang 1-7, Ang III and Ang II. These methods were applied to analyze angiotensin peptides in bovine adrenal microvascular endothelial cells. The results show that Ang II is metabolized by endothelial cells to Ang 1-7, Ang III and Ang IV with Ang 1-7 being the major metabolite.

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“…A clinical study assessed the using of brain-penetrating ACE inhibitors in treating AD patients with hypertension has found that using brain-penetrating ACE inhibitors could slow the deterioration of cognitive function of these patients (Ohrui et al 2004), because ACE inhibitors may enhance the release of acetylcholine in human and rat entorhinal cortex slices (Barnes et al 1992). The improved cognition with ACE inhibitors was shown in another study (Tzourio et al 2003).…”

Section: Ace Inhibitors In Cognitive Functionmentioning

confidence: 98%

Angiotensin-Converting Enzyme Gene in Alzheimer's Disease

Yang

Liu

2008

Tohoku J. Exp. Med.

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Dementia has been increasing exponentially in recent years, especially in Asia. This increasing prevalence calls for the necessity of antecedent biomarkers. The angiotensinconverting enzyme (ACE) gene, located on chromosome 17q23, has been regarded as a candidate susceptibility gene for Alzheimer's disease (AD), because ACE could degrade β -amyloid, the pathological hallmark of AD, thereby inhibiting its aggregation. The level and activity of ACE, in part, may be modulated by the insertion or deletion (indel) polymorphism of ACE gene. The indel polymorphism, consisting of the presence or absence of a 287-bp DNA fragment, has been considered the biomarker of AD, although its validity varies with race. In the Japanese, seemingly different results have been reported. One report shows significant association of insertion homozygote with AD, whereas other shows no association of indel polymorphism with AD. In the Taiwanese, the significant association of deletion homozygote with AD was found. Moreover, clinical studies have shown that using ACE inhibitors could slow the deterioration of cognitive function in AD patients, despite that ACE can degrade β -amyloid. These heterogeneous results on the association of ACE gene with AD and clinical significance of using ACE inhibitor in AD highlight the necessity of exploring detailed mechanisms from the ACE gene to the development of AD. These detailed mechanisms and findings may serve as the basis for further study.

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Angiotensin-Converting Enzyme Inhibition, Angiotensin, and Cognition

Cited by 65 publications

References 0 publications

Effects of Blood Pressure Changes on Alzheimer’s Disease

Effects of Blood Pressure Changes on Alzheimer’s Disease

Simultaneous analysis of angiotensin peptides by LC–MS and LC–MS/MS: Metabolism by bovine adrenal endothelial cells

Angiotensin-Converting Enzyme Gene in Alzheimer's Disease

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