Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Colombian patients

Camelo, Dalila; Arboleda, Gonzalo; Londoño, Juan José Yunis; Pardo, Rodrigo; Arango, Gabriel Misas; Solano, Eugenia; Rebolledo, Leonardo Andrés López; Hedmont, Daniel; Arboleda, Humberto

doi:10.1016/j.jns.2003.10.008

Cited by 22 publications

(7 citation statements)

References 21 publications

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“…There have been case reports of clinical deterioration of HD with ACE inhibitors [23]. There are suggestions of a possible contribution of ACE genotypes to HD but the bulk of the published data suggests no association as found in our study [9, 10,24,25,26,27]. …”

Section: Discussioncontrasting

confidence: 59%

A Study of Potential Interactive Genetic Factors in Huntington’s Disease

Panegyres

Beilby²,

Bulsara

et al. 2006

Eur Neurol

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Aim: To assess the role of genetic factors, other than the CAG repeat length, on the development of Huntington’s disease (HD) in an isolated Caucasian population in the south-west of Western Australia. Methods: 114 patients with symptomatic HD according to the Unified HD Rating Scale research criteria were examined along with 51 control patients. The length of the CAG repeat sequence in the IT15 gene and the adjacent CCG and Δ2642 polymorphisms were determined by polymerase chain reaction along with common genotypes of the angiotensin-converting enzyme (ACE) and apolipoprotein E (APOE) genes. Results: The CAG expansion was associated with age of onset and the development of neurological dysfunction. We found no effect of the expanded CCG allele on age of onset, neurological dysfunction or the size of the CAG expansion. We observed a twofold increase in the Δ2642 polymorphism and the risk of developing symptomatic HD which was not significant (OR 2.06; 95% CI 0.60–7.07). The presence of an APOE Ε4 allele was associated with an increased risk of HD which was not significant either (OR 1.04–1.73; 95% CI 0.10–10.68). ACE genotypes showed no association with risk factors for the disease. Conclusion: In our study of a geographically isolated Caucasian HD population in the south-west of Western Australia we have not observed that the expanded CCG allele, the Δ2642 polymorphism, the APOE Ε4 allele and ACE genotypes are associated with an increased risk for the development of symptomatic HD.

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Section: Discussioncontrasting

confidence: 59%

A Study of Potential Interactive Genetic Factors in Huntington’s Disease

Panegyres

Beilby²,

Bulsara

et al. 2006

Eur Neurol

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“…Similarly, Bray et al (2001) found that the frequency of the D allele is 0.537. There are also some studies of ethnic populations in South America (Henderson et al 2004;Jalil et al 1999;Cameloa et al 2004). Henderson et al (2004) studied the ACE polymorphism in 551 subjects in the Multiethnic Cohort and reported a D allele frequency of 0.482.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of the Angiotensin I Converting Enzyme Gene Insertion/Deletion Polymorphism in a Healthy Turkish Population

Berdelı

Çam

2009

Biochem Genet

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Angiotensin converting enzyme (ACE) plays an essential role in the renin-angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations.

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“…Literature review revealed the association between ACE I/D polymorphism and incidence of LOAD in 14 studies (Alvarez et al, 1999;Cheng et al, 2002;Crawford et al, 2000;Hu et al, 1999;Kehoe et al, 1999Kehoe et al, , 2003Kölsch et al, 2005;Mattila et al, 2000;Narain et al, 2000;Ning et al, 2010;Richard et al, 2001; which shows positive association. However, there was no association between this polymorphism and LOAD in 20 studies (Buss et al, 2002;Camelo et al, 2004;Carbonell et al, 2003;Chapman et al, 1998;Cousin et al, 2009;Keikhaee et al, 2006;Lehmann et al, 2005;Lendon et al, 2002;Meng et al, 2006;Monastero et al, 2002;Myllykangas et al, 2000;Nacmias et al, 2007;Palumbo et al, 1999;Panza, 2002;Perry et al, 2001;Scacchi et al, 1998;Seripa et al, 2003;Wakutani et al, 2002;Wehr et al, 2006;Zuliani et al, 2001) showing negative association.…”

Section: Resultsmentioning

confidence: 95%

Lack of association between two ACE gene polymorphisms (rs4291 and Alu I/D) and late onset Alzheimer’s disease

Yenki¹,

Safari²,

Azimi

2012

Afr. J. Biotechnol.

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Alzheimer's disease (AD) is a prevalent disorder and the most common cause of dementia in elderly populations. Genetic and environmental factors together play a role in developing late onset Alzheimer's disease (LOAD). According to the recent published papers, ACE is one of the candidate susceptibility genes for LOAD. In this study, allele and genotype frequencies for rs4291 and rs1799752 polymorphisms of ACE gene, for 100 Iranian patients, affected with AD and 100 healthy controls were compared using Chi-square test. No statistically significant differences were found in genotype and allele frequencies of rs4291 and rs1799752 polymorphisms between our LOAD patients and controls. The pair-wise haplotype analysis of rs4291-240 A/T and rs1799752 Alu I/D polymorphisms were also performed, but no significant associations were identified.

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Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Colombian patients

Cited by 22 publications

References 21 publications

A Study of Potential Interactive Genetic Factors in Huntington’s Disease

A Study of Potential Interactive Genetic Factors in Huntington’s Disease

Prevalence of the Angiotensin I Converting Enzyme Gene Insertion/Deletion Polymorphism in a Healthy Turkish Population

Lack of association between two ACE gene polymorphisms (rs4291 and Alu I/D) and late onset Alzheimer’s disease

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