Angiotensin-converting enzyme activity in serum and bronchoalveolar lavage fluid after damage to the alveolo-capillary barrier in the human lung

Jongh, R. F. De; Backer, Wilfried A. De; Mohan, Rajeev; Jorens, Philippe G.; Overveld, F. J. van

doi:10.1007/bf01724878

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Even if there are some studies related to the use of corticosteroids to prevent these side-effects, many different studies show conflicting results about this topic. 9,17,21,22 In conclusion, although some operative techniques (e.g. beating heart surgery and its variants) have been developed, recently, these are suitable for only some patients and cardiopulmonary bypass is still the main technique used in cardiovascular surgery.…”

Section: Discussionmentioning

confidence: 99%

The side-effects of cardiopulmonary bypass on the lungs: changes in bronchoalveolar lavage fluids

et al. 2001

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Although technical refinements have improved the safety of cardiac operations, postoperative dysfunction of lung and other organs occurs frequently after cardiopulmonary bypass (CPB). The aim of the present study was to search the aetiopathogenesis of pulmonary complications due to CBP. Ten patients with stable coronary artery disease, undergoing coronary artery bypass grafting (CABG) surgery, were included in the study. Forty bronchoalveolar lavage (BAL) fluid samplings were performed in the 10 patients. Samples were obtained at the following time periods: (1) preoperatively; (2) at the end of the first hour after anaesthetic induction; (3) at the conclusion of 30 min of crossclamp on CPB; and (4) at the conclusion of 20 h after the end of CPB, postoperatively. Cell contents of bronchoalveolar lavage fluid, alveolar macrophage viability, eosinophil cationic protein (ECP) levels and myeloperoxidase (MPO) concentrations were analysed in each bronchoalveolar lavage fluids. While the percentage of preoperative macrophages was 85.90% and the percentage of preoperative neutrophils was 2.40%, they were 77.00% and 11.30% in the postoperative samples, respectively. Mean alveolar macrophage viability was 96.20% preoperatively and 90.40% in the postoperative period. Preoperative eosinophil cationic protein mean concentration was < 2 microg/l and mean response value (RV) was 28.80. Preoperative mean myeloperoxidase concentration was 7.66 ng/ml. Postoperative eosinophil cationic protein mean response value was 63.40 and mean myeloperoxidase concentration was 59.25 ng/ml. There were significant differences between third and final samples with regard to both neutrophil percentages (p = 0.028) and MPO levels (p = 0.005). While the preoperative mean PaO2 value was 89.39 mmHg and mean SaO2 value was 97.12%, they were calculated in the postoperative arterial blood specimens of patients, without inhaling O2, as 65.31 mmHg and 93.84%. These changes between blood gas analyses reflect the impairment of the lungs (p = 0.009 and p = 0.007, respectively). Neither alveolar macrophage viability nor ECP levels changed significantly between consecutive periods. However, when the results of the first and fourth samples were compared, we saw the cumulative effects of CPB, in that alveolar macrophages lost their viability and ECP mean RVs rose. These changes were statistically significant (p = 0.027 and p = 0.013, respectively). However, postoperative ECP levels were not like those found in a patient with asthma. Also, changes between alveolar macrophage percentages (p = 0.028), between neutrophil percentages (p = 0.036) and between MPO concentrations (p = 0.005) were statistically significant. Again, changes in neutrophil percentages between first and final samples correlated with changes in MPO levels between same periods (r = 0.657, p = 0.039).

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Section: Discussionmentioning

confidence: 99%

The side-effects of cardiopulmonary bypass on the lungs: changes in bronchoalveolar lavage fluids

et al. 2001

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“…Clinical data regarding the suitability of ACE as a biomarker for lung damage is inconsistent. Whereas some studies have shown a positive correlation between elevations of ACE in serum or bronchoalveolar lavage fluids of patients suffering from acute respiratory distress syndrome (ARDS, including alveolar edema) or sarcoidosis [33,36,37], others doubt the prognostic value of ACE levels [38,39]. Besides its role as potential biomarker, ACE has been discussed as mediator of lung injury and blocking of ACE activity has been shown to attenuate inflammation [40,41].…”

Section: Sp-a In Blood Perfusionsmentioning

confidence: 99%

Surfactant Protein A (SP-A) and Angiotensin Converting Enzyme (ACE) as Early Biomarkers for Pulmonary Edema Formation in Ventilated Human Lung Lobes

Gnadt

Kardziev²,

Schmidt

et al. 2012

Lung

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“…Angiotensins are peptides involved in maintaining blood pressure control and arterial hypertension by increasing the secretion of aldosterone 11 and promoting sodium retention by the kidneys 12 . ACE2 receptors are attached to the surfaces of the lungs, heart, and kidney cell membranes 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Potential activity of a selected natural compounds on SARS-CoV-2 RNA-dependent-RNA polymerase, and binding affinity of the receptor-binding domain (RBD)

Altayeb

Bouslama

Abdulhakimc

et al. 2020

Preprint

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Coronavirus disease (COVID-19) is caused by SARS-CoV-2 and represents the causative agent of a potentially lethal disease. COVID-19 has been described as a significant global public health pandemic by the World Health Organization due to its high mortality rate, rapid spread, and the lack of drugs and vaccines for it. Active antiviral drugs are desperately needed to combat the potential return of severe acute respiratory syndrome (SARS).In this study, we selected 39 natural compounds present in plants, algae, and sponges with antiviral activity. Molecular docking was used to screen the compounds’ activity on SARS- CoV-2 RNA-dependent-RNA polymerase, receptor-binding domain (RBD), and the human ACE2 receptor. Compounds with binding energy ≤ -6.5 kcal/mol enter pre-clinical testing using in silco ADME/Tox (absorption, distribution, metabolism, excretion, and toxicity).We found eight potential SARS-CoV-2 inhibitors: (glycyrrhizin, rutin, baicalin, 1, 6-di-O- galloyl-beta-D-glucose, pyropheophorbide A, pheophorbide A, beta-Sitosterol, and vitexin). These outcomes indicate that these compounds could be potential candidates to be utilized in lead optimization for the design and production of the anti-SARS-CoV-2 drug.

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Angiotensin-converting enzyme activity in serum and bronchoalveolar lavage fluid after damage to the alveolo-capillary barrier in the human lung

Abstract: Angiotensin-converting enzyme activity in serum or bronchoalveolar lavage fluid does not reflect damage of endothelial cells or damage of alveolocapillary integrity in acute pulmonary disease.

Cited by 4 publications

References 26 publications

The side-effects of cardiopulmonary bypass on the lungs: changes in bronchoalveolar lavage fluids

The side-effects of cardiopulmonary bypass on the lungs: changes in bronchoalveolar lavage fluids

Surfactant Protein A (SP-A) and Angiotensin Converting Enzyme (ACE) as Early Biomarkers for Pulmonary Edema Formation in Ventilated Human Lung Lobes

Potential activity of a selected natural compounds on SARS-CoV-2 RNA-dependent-RNA polymerase, and binding affinity of the receptor-binding domain (RBD)

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