Angiotensin converting enzyme activity in hypertensive pregnancy

Lee, Milton I.; Bottoms, Sidney F.; Sokol, Robert J.; Todd, H.

doi:10.1515/jpme.1987.15.3.258

Cited by 10 publications

(2 citation statements)

References 10 publications

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“…The reduced plasma ACE activity observed in pregnant normotensive rats 39 may explain the increased depressor responses to BK in pregnant compared with non‐pregnant normotensive rats and may contribute to a physiological adaptation in normal pregnancy. However, it does not seem to happen in SHR, because the systemic depressor responses to BK are unchanged in pregnant compared with non‐pregnant SHR 15 .…”

Section: Discussionmentioning

confidence: 99%

Captopril Reverses the Reduced Vasodilator Response to Bradykinin in Hypertensive Pregnant Rats

Resende

Pimentel

Moura

2004

Clin Exp Pharma Physio

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1. Pregnancy in rats is characterized by a reduction in arterial pressure that is associated with a decreased response to vasoconstrictors. However, the responses to vasodilators in isolated vessels remain controversial and are not well established in hypertensive pregnant rats. 2. In the present study, we investigated the effect of pregnancy on the bradykinin (BK)-induced vasodilator responses of the isolated mesenteric arterial bed (MAB) from Wistar normotensive and spontaneously hypertensive rats (SHR) and determined the role of nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF) and angiotensin-converting enzyme (ACE) in these responses. 3. Mean arterial pressure (MAP) in pregnant normotensive and pregnant hypertensive rats (93 +/- 1 and 122 +/- 2 mmHg, respectively) was lower than in non-pregnant controls (128 +/- 1 and 163 +/- 2 mmHg, respectively; P < 0.05). In MAB isolated from normotensive rats and precontracted with phenylephrine, the effects of bradykinin, acetylcholine (ACh) and nitroglycerine (NG) were not influenced by pregnancy. In contrast, the vasodilator responses to BK were significantly reduced in pregnant compared with non-pregnant SHR and seemed to be specific to BK. 4. The ACE inhibitor captopril potentiated BK vasodilator responses and abolished the differences between pregnant and non-pregnant SHR. Inhibition of nitric oxide (NO) synthase by N(G)-nitro-L-arginine methyl ester (l-NAME) significantly reduced the vasodilator effect of BK in all groups. In the presence of l-NAME plus high K+ solution (47 mmol/L), BK-induced vasodilation was completely blocked. The NO-dependent component of the responses seems to be more important in hypertensive rats and pregnancy does not modify this profile. 5. Our results suggest that increased ACE activity may be involved in the pregnancy associated reduction in vasodilator responses to BK in the MAB of hypertensive rats. Pregnancy does not modify the relative contribution of the EDHF and NO to the vasodilator effect of BK.

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Section: Discussionmentioning

confidence: 99%

Captopril Reverses the Reduced Vasodilator Response to Bradykinin in Hypertensive Pregnant Rats

Resende

Pimentel

Moura

2004

Clin Exp Pharma Physio

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“…This suggests that increased BK depressor responses in pregnancy may be due to reduced ACE activity and hence a prolonged BK half-life. Although we did not directly measure ACE activity in the present study, ACE activity has been reported to be reduced in normotensive pregnancy in women (Lee et al 1987). Systemic depressor responses to BK were unchanged in pregnant vs nonpregnant SHR, and we therefore suggest that decreased ACE activity in pregnancy does not occur in SHR.…”

Section: Discussionmentioning

confidence: 59%

The Role of Angiotensin Converting Enzyme and Nitric Oxide in the Enhanced Systemic Depressor Responses to Bradykinin in Pregnant Rats

Chu

Beilin

1995

Clin Exp Pharma Physio

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1. In the present study we have examined the effects of angiotensin I converting enzyme (ACE) inhibition and nitric oxide (NO) synthesis inhibition on bradykinin (BK) depressor responses in pregnancy in both Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. Ramipril (10 mg/kg, i.v.) significantly reduced mean blood pressure (MBP) in all animals. Further administration of L-nitro-arginine (L-NOARG, 20 mg/kg, i.v.) increased MBP to a less extent in pregnant WKY and to a similar level in pregnant SHR compared with their non-pregnant controls (controls), respectively. 3. Systemic depressor responses to BK were increased in pregnant WKY and were unchanged in pregnant SHR as compared with their controls. Ramipril (10 mg/kg, i.v.) potentiated BK responses in all groups, and abolished the differences between pregnant and non-pregnant WKY. Further administration of L-NOARG (20 mg/kg, i.v.) did not further influence BK responses in all groups. 4. The results suggest that systemic depressor responses to BK are enhanced in pregnant WKY and unchanged in pregnant SHR. Decreased ACE activity may contribute to enhanced systemic depressor responses to BK in pregnant WKY.

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Humorale Faktoren bei Patientinnen mit Schwangerschaftshypertonie

Niesert

1989

Gynäkologie Und Geburtshilfe 1988

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Angiotensin converting enzyme activity in hypertensive pregnancy

Cited by 10 publications

References 10 publications

Captopril Reverses the Reduced Vasodilator Response to Bradykinin in Hypertensive Pregnant Rats

Captopril Reverses the Reduced Vasodilator Response to Bradykinin in Hypertensive Pregnant Rats

The Role of Angiotensin Converting Enzyme and Nitric Oxide in the Enhanced Systemic Depressor Responses to Bradykinin in Pregnant Rats

Humorale Faktoren bei Patientinnen mit Schwangerschaftshypertonie

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