Angiotensin AT1 and AT2 receptors contribute to drinking elicited by eating in rats

Kraly, F. Scott; Tribuzio, R. A.; Kim, Young-Mee; Keefe, M. E.; Braun, Christian; Newman, Beverley

doi:10.1016/0031-9384(95)02049-7

Cited by 14 publications

(5 citation statements)

References 35 publications

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“…It is possible that, besides the acute duration of the present study, the dose about six times smaller might have not been enough to induce adequate blockade. Nevertheless, impaired fluid intake is compatible with previous findings, 50 since drinking might be elicited as a reflective response to feeding 51 . Food deprivation for 48 h significantly decreased plasma glucose concentration and this hypoglycaemic response was attenuated by continuous treatment with oral losartan.…”

Section: Discussionsupporting

confidence: 91%

“…Nevertheless, impaired fluid intake is compatible with previous findings, 50 since drinking might be elicited as a reflective response to feeding. 51 Food deprivation for 48 h significantly decreased plasma glucose concentration and this hypoglycaemic response was attenuated by continuous treatment with oral losartan. A certain level of interaction of glucose homeostasis might be found at pancreatic islets level, for they express AT 1 Rs in β-cells, 52 and their overactivation may lead to oxidative stress and cellular apoptosis.…”

Section: Discussionmentioning

confidence: 92%

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Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats

Paes‐Leme

Monteiro

Gholami

et al. 2023

J Neuroendocrinology

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Besides being recognised for involvement in cardiovascular control and hydromineral balance, the renin‐angiotensin system (RAS) has also been associated with the neuroendocrine control of energy balance. One of the main brain sites for angiotensin II (ANG II)/type 1 receptor (AT1R) signalling is the subfornical organ (SFO), a circumventricular organ related to the control of autonomic functions, motivated behaviours and energy metabolism. Thus, we hypothesised that circulating ANG II may act on the SFO AT1R receptors to integrate metabolic and hydromineral balance. We evaluated whether food deprivation can modulate systemic RAS activity and Agrt1a brain expression, and if ANG II/AT1R signalling influences the hypothalamic expression of mRNAs encoding neuropeptides and food and water ingestion in fed and fasted Wistar rats. We found a significant increase in both ANG I and ANG II plasma levels after 24 and 48 hours of fasting. Expression of Agrt1a mRNA in the SFO and paraventricular nucleus (PVN) also increased after food deprivation for 48 h. Treatment of fasted rats with low doses of losartan in drinking water attenuated the decrease in glycemia and meal‐associated water intake without changing the expression in PVN or arcuate nucleus of mRNAs encoding selected neuropeptides related to energy homeostasis control. These findings point to a possible role of peripheral ANG II/SFO‐AT1R signalling in the control of re‐feeding‐induced thirst. On the other hand, i.c.v. losartan treatment decreased food and water intake over dark time in fed but not in fasted rats.This article is protected by copyright. All rights reserved.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 92%

Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats

Paes‐Leme

Monteiro

Gholami

et al. 2023

J Neuroendocrinology

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“…Although each angiotensin blocker used in our experiments inhibited Oct-induced drinking, there were some variations in the magnitude of the inhibition: Sar was less effective than Cap or Los. We used doses of these compounds that were previously reported to inhibit angiotensinergic drinking (21,30), but it could not be excluded that there were some differences in the potency and/or diffusion among the various angiotensin blockers. In addition, unlike Los, Sar also displays partial ANG II agonist activity, which makes it a less effective antagonist than Los (reviewed in Ref.…”

Section: Discussionmentioning

confidence: 99%

“…To determine the mechanisms involved in the mediation of Oct-induced drinking, water consumption was measured after intracerebroventricular injection of 0.1 g of Oct in rats pretreated as follows: 30 g of Cap (Sigma-Aldrich, Budapest) in 2 l or 10 g of Atr (atropine sulfate, Egis, Budapest) in 10 l were intracerebroventricularly injected 15 min before Oct, 10 g of Sar (Peninsula Laboratories, Belmont, CA) in 2 l were intracerebroventricularly administered 10 min before Oct, 100 g of Los (Merck Research Laboratories, Rahway, NJ) in 2 l were intracerebroventricularly injected 5 min before Oct, and 1 mg/kg of Nal (Narcanti, Du Pont Pharma, Bad Homburg, Germany) in a volume of 0.25 ml/100 g was subcutaneously injected 20 min before Oct. The doses of the antagonists corresponded to previously reported doses that were effective in inhibiting carbachol-or ANG II-induced drinking (15,21,30). This injection protocol required baseline measurements of water intake after double intracerebroventricular injections of PS/Veh (or subcutaneous ϩ intracerebroventricular PS for the experiments with Nal), after PS/Veh ϩ 0.1 g Oct, and after pretreatments with each of the compounds above ϩ intracerebroventricular injection of PS/Veh.…”

Section: Animalsmentioning

confidence: 99%

Octreotide-induced drinking, vasopressin, and pressure responses: role of central angiotensin and ACh

Hajdu

Obál²,

Gardi

et al. 2000

American Journal of Physiology-Regulatory, Integrative and Comp

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The involvement of central angiotensinergic and cholinergic mechanisms in the effects of the intracerebroventricularly injected somatostatin analog octreotide (Oct) on drinking, blood pressure, and vasopressin secretion in the rat was investigated. Intracerebroventricular Oct elicited prompt drinking lasting for 10 min. Water consumption depended on the dose of Oct (0.01, 0.1, and 0. 4 microgram). The drinking response to Oct was inhibited by pretreatments with the intracerebroventricularly injected angiotensin-converting enzyme inhibitor captopril, the AT(1)/AT(2) angiotensin receptor antagonist saralasin, the selective AT(1) receptor antagonist losartan, or the muscarinic cholinergic receptor antagonist atropine. The dipsogenic effect of Oct was not altered by prior subcutaneous injection of naloxone. Oct stimulated vasopressin secretion and enhanced blood pressure. These responses were also blocked by pretreatments with captopril or atropine. Previous reports indicate that the central angiotensinergic and cholinergic mechanisms stimulate drinking and vasopressin secretion independently. We suggest that somatostatin acting on sst2 or sst5 receptors modulates central angiotensinergic and cholinergic mechanisms involved in the regulation of fluid balance.

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“…Meal-associated drinking has been demonstrated to be independent from systemic osmotic changes in the rat (KRALY et al, 1995). As shown in different studies, drinking induced by eating appears to be regulated by various mechanisms, involving the release of angiotensin (KRALY et al, 1995) and histamine (KRALY, 1983;KRALY et al, 1995b). Histamine has been characterised as one of the most important factors for prandial drinking in the rat (KRALY, 1983;KRALYet al, 1995a).…”

Section: Introductionmentioning

confidence: 98%

Food‐associated Drinking in Pygmy Goats: Importance of Histamine Receptors

Rossi

Rokitzky

Prete

et al. 1997

Journal of Veterinary Medicine Series A

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Summary The combined effect of the histamine receptor antagonists Dexbrompheniramine (DXB: H1‐receptor antagonist) and Cimetidine (C: H2‐receptor antagonist) on food and water intake was investigated in pygmy goats. DXB (1 mg/kg BW0.75) and C (16 mg/kg BW0.75) were injected together intraperitoneally (i.p.)‐Cumulative food and water intake, as well as meal and draft pattern, were recorded. DXB and C significantly reduced cumulative water intake, whereas cumulative food intake did not change. Water to food ratio was also significantly diminished. Draft frequency and the percentage of drafts associated with meals were significantly reduced during the 6 h post injection, while meal frequency and meal size did not change during this period. The results show that blockade of the H1 and H2‐histamine receptors attenuates the association between water and food intake in pygmy goats. Therefore, mechanisms responsible for meal‐associated drinking seem to depend upon activation of histamine receptors.

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Angiotensin AT1 and AT2 receptors contribute to drinking elicited by eating in rats

Cited by 14 publications

References 35 publications

Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats

Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats

Octreotide-induced drinking, vasopressin, and pressure responses: role of central angiotensin and ACh

Food‐associated Drinking in Pygmy Goats: Importance of Histamine Receptors

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