Angiotensin-(1–7)/Mas axis integrity is required for the expression of object recognition memory

Lazaroni, Thiago L.N.; Raslan, Ana C.S.; Fontes, Walkíria Ramos Peliky; Oliveira, Marilene; Bäder, Michael; Alenina, Natalia; Moraes, Márcio Flávio Dutra; Santos, Robson A.S.; Pereira, Grace Schenatto

doi:10.1016/j.nlm.2011.10.003

Cited by 76 publications

(54 citation statements)

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“…Ang-(1-7) may modulate other responses, including inflammation, reproduction, neuroprotection, learning and memory, anxiety and depression [8,9,12,[32][33][34]. Our present results showed that anxiety-type behaviour in TGRs exposed to the EPM test can be attenuated by ICV administration of Ang- (1-7).…”

Section: Discussionsupporting

confidence: 57%

Anxiolytic- and antidepressant-like effects of angiotensin-(1–7) in hypertensive transgenic (mRen2)27 rats

et al. 2016

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Angiotensin-(1-7) [Ang-(1-7)], a counter-regulatory peptide of the renin-angiotensin system (RAS) exerts its effects through the G-protein-coupled receptor Mas, which is expressed in different tissues, including the brain. Ang-(1-7) has a broad range of effects beyond the well-described cardiovascular and renal actions, including the modulation of emotional and behavioural responses. In the present study we tested the hypothesis that Ang-(1-7) could attenuate the anxiety- and depression-like behaviours observed in transgenic hypertensive (mRen2)27 rats (TGRs). We also hypothesized that Ang-(1-7) could be involved in the anxiolytic-like effect induced by ACE (angiotensin-converting enzyme) treatment in these hypertensive rats. Therefore, TGRs and Sprague-Dawley rats were subjected to the Elevated Plus Maze (EPM) test, Forced Swimming Test (FST) and Novelty Suppressed Feeding (NSF). TGRs presented a decreased percentage of entries in the open arms of the EPM test, a phenotype reversed by systemic treatment with enalapril or intracerebroventricular infusion of Ang-(1-7). It is interesting that pre-treatment with A779, a selective Mas receptor antagonist, prevented the anxiolytic-like effect induced by the ACE inhibitor. In the NSF test, TGRs showed increased latency to eating, an indicative of a higher aversion in response to a new environment. These animals also showed increased immobility in the FST. Again, Ang-(1-7) reversed this phenotype. Thus, our data showed that Ang-(1-7) can modulate anxiety- and depression-like behaviours in TGRs and warrant further investigation as a new therapy for certain psychiatric disorders.

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Section: Discussionsupporting

confidence: 57%

Anxiolytic- and antidepressant-like effects of angiotensin-(1–7) in hypertensive transgenic (mRen2)27 rats

et al. 2016

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“…Surprisingly however, only insignificant improvements in the hippocampus-dependent spatial learning were observed in Mas-KO mice (Walther et al, 1998(Walther et al, , 2000a. In contrast, object recognition memory, another hippocampusdependent behavior, was impaired in these animals (Lazaroni et al, 2012), confirming an important but yet elusive role of Mas in hippocampal functions that is not linked to its electrophysiologic actions. However, it may be explained by the role of Mas in neuronal NO generation, which is also involved in memory formation (Yang et al, 2011).…”

Section: F Mas In Behaviormentioning

confidence: 84%

Mas and Its Related G Protein–Coupled Receptors, Mrgprs

et al. 2014

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“…Ang-(1-7) not only participates in BP or baroreflex regulation in the brain, but has been shown to improve object recognition memory function [52]. Furthermore, central administration of Ang-(1-7) induces anxiolytic-like effects and decreased oxidative stress in the amygdale of rats [53].…”

Section: Beyond the Brain Effects Of Ang-(1-7) On Blood Pressurementioning

confidence: 99%

Protective axis of the renin–angiotensin system in the brain

et al. 2014

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The RAS (renin-angiotensin system) is composed of two arms: the pressor arm containing AngII (angiotensin II)/ACE (angiotensin-converting enzyme)/AT1Rs (AngII type 1 receptors), and the depressor arm represented by Ang-(1-7) [angiotensin-(1-7)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1-7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1-7) is injected into the nucleus of the solitary tract, caudal ventrolateral medulla, paraventricular nucleus or anterior hypothalamic area, a reduction in BP occurs; however, when injected into the rostral ventrolateral medulla, Ang-(1-7) stimulates an increase in BP. In contrast with AngII, Ang-(1-7) improves baroreflex sensitivity and has an inhibitory neuromodulatory role in hypothalamic noradrenergic neurotransmission. Ang-(1-7) not only exerts effects related to BP regulation, but also acts as a cerebroprotective component of the RAS by reducing cerebral infarct size and neuronal apoptosis. In the present review, we provide an overview of effects elicited by Ang-(1-7) in the brain, which suggest a potential role for Ang-(1-7) in controlling the central development of hypertension.

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Angiotensin-(1–7)/Mas axis integrity is required for the expression of object recognition memory

Cited by 76 publications

References 100 publications

Anxiolytic- and antidepressant-like effects of angiotensin-(1–7) in hypertensive transgenic (mRen2)27 rats

Anxiolytic- and antidepressant-like effects of angiotensin-(1–7) in hypertensive transgenic (mRen2)27 rats

Mas and Its Related G Protein–Coupled Receptors, Mrgprs

Protective axis of the renin–angiotensin system in the brain

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