Angiotensin-(1-7) and Bradykinin in Baroreceptor Reflex Sensitivity in Hypertension

Tsuda, Kazushi

doi:10.1161/hypertensionaha.111.00523

Cited by 4 publications

(1 citation statement)

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“…Ang-(1–7) is a key component of the renin-angiotensin system, which can counter-regulate several deleterious effects caused by Ang II. There is no denying that brain Ang-(1–7) has well-characterized actions in the regulation of arterial pressure and the BRS ( Campagnole-Santos et al, 1989 ; Tsuda, 2013 ). In this study we have examined the concentrations of Ang II and Ang-(1–7) in the NTS tissues of control and sleep deprived rats.…”

Section: Discussionmentioning

confidence: 99%

Sleep deprivation reduces the baroreflex sensitivity through elevated angiotensin (Ang) II subtype 1 receptor expression in the nucleus tractus solitarii

Liu,

Wang,

Sun

et al. 2024

Front. Neurosci.

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IntroductionSleep insufficiency has been linked to an increased risk of high blood pressure and cardiovascular diseases. Emerging studies have demonstrated that impaired baroreflex sensitivity (BRS) is involved in the adverse cardiovascular effects caused by sleep deprivation, however, the underlying mechanisms remain unknown. Therefore, the present study aims to clarify the role of abnormal renin-angiotensin system in the nucleus tractus solitarii (NTS) in impaired BRS induced by sleep deprivation.MethodsRats were randomly divided into two groups: normal sleep (Ctrl) and chronic sleep deprivation (CSD) group. Rats were sleep deprived by an automated sleep deprivation system. The blood pressure, heart rate, BRS, the number of c-Fos positive cells and the expression of angiotensin (Ang) II subtype 1 receptors (AT1R) in the NTS of rats were assessed.ResultsCompared to Ctrl group, CSD group exhibited a higher blood pressure, heart rate, and reduced BRS. Moreover, the number of c-Fos positive cells and local field potential in the NTS in CSD group were increased compared with the Ctrl group. It was shown that the expression of the AT1R and the content of Ang II and the ratio of Ang II to Ang-(1–7) were increased in the NTS of rats in CSD group compared to Ctrl group. In addition, microinjection of losartan into the NTS significantly improved the impaired BRS caused by sleep deprivation.DiscussionIn conclusion, these data suggest that the elevated AT1R expression in the NTS mediates the reduced BRS induced by chronic sleep deprivation.

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Section: Discussionmentioning

confidence: 99%