Angiotensin‐(1‐7) Actions in Animal Models of Metabolic Syndrome: a Systematic Review

Abstract

This systematic review aims to collect all available data of Ang‐(1‐7) in animal models to study metabolic syndrome (MetS). The following electronic bibliographic databases have been searched: PubMed, EMBASE, Web of Science, and Scopus. The full search strategy was based on the search components “animal models”, “metabolic syndrome” and “angiotensin‐(1‐7)”. No publication date or language restrictions have been applied. The protocol of this study is available online in PROSPERO. The comprehensive search retrieved a total of 2056 citations (EMBASE, n = 816; PubMed, n = 285; SCOPUS, n = 290; Web of Science, n = 665). All citations were saved into one file in reference software. After removing duplications (n = 891), a total of 1419 citations were screened considering title and abstract, resulting in 149 citations selected as potentially relevant articles. These were then screened considering the full text content, resulting in 54 citations for data extraction. The other citations were either duplications (n = 4), conference abstracts (n = 66), or did not match inclusion criteria for disease and/or intervention (n = 25). Data extraction revealed that 31 of 54 studies, besides evaluating metabolism, have performed in vivo and/or ex vivo protocols to analyze the effects of increasing Ang‐(1‐7) availability (n = 27) or Mas receptor blockade (n = 4) on cardiovascular system. Among the other 23 citations that did not study cardiovascular parameters, 20 evaluated Ang‐(1‐7) effects on metabolism, and 3, the blockade or knockout of Mas recector. Outcomes are still being extracted and categorized for reporting. All database searches have been performed in July, 2019. This systematic review may gather all available data of Ang‐(1‐7) in animal models to study MetS, based on original full text articles, and categorize it by type of interventions, animal models, MetS induction method, and outcome measures. These results may contribute to highlight the efficacy of Ang‐(1‐7) on MetS risk factors as well as possible related gaps in the literature in this concern. Support or Funding Information FAPEAL, CAPES, CNPq