Angiostatic activities of medroxyprogesterone acetate and its analogues

Yamamoto, Takashi; Terada, Nobuyuki; Nishizawa, Yasuko; Petrow, V.

doi:10.1002/ijc.2910560318

Cited by 55 publications

(11 citation statements)

References 19 publications

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“…In contrast, high doses of oral progesterone reduce the endometrial microvascular density [9]. A direct anti-angiogenic action has been detected in assays with medroxyprogesterone acetate [10], which seems to have an angiostatic action [11].…”

Section: Discussionmentioning

confidence: 89%

Use of the levonorgestrel-releasing intrauterine device for the symptomatic treatment of uterine myomas

Silva

Reis

et al. 2004

International Congress Series

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Section: Discussionmentioning

confidence: 89%

Use of the levonorgestrel-releasing intrauterine device for the symptomatic treatment of uterine myomas

Silva

Reis

et al. 2004

International Congress Series

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“…Investigators have reported that androgens may significantly alter the development of allergic conjunctivitis in rabbits5 and that these hormones may have a beneficial influence on the corneal epithelium, acting to correct defects, facilitate wound healing,6 7 47 suppress angiogenesis,48 and stimulate mitosis 15. In fact, a pharmaceutical firm in South America (Laboratórios Frumtost SA/Allergan-Lok, Guarulhos, Brazil) has marketed topical androgens for the therapy of corneal trauma, cicatrisation, erosions, ulcers, and atrophy, as well as for promoting postoperative care after corneal transplantation.…”

Section: Discussionmentioning

confidence: 99%

Identification of androgen receptor protein and 5alpha -reductase mRNA in human ocular tissues

Rocha

2000

British Journal of Ophthalmology

201

106

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Background/aims-Androgens have been reported to influence the structural organisation, functional activity, and/or pathological features of many ocular tissues. In addition, these hormones have been proposed as a topical therapy for such conditions as dry eye syndromes, corneal wound healing, and high intraocular pressure. To advance our understanding of androgen action in the eye, the purpose of the present study was twofold: firstly, to determine whether tissues of the anterior and posterior segments contain androgen receptor protein, which might make them susceptible to hormone eVects following topical application; and, secondly, to examine whether these tissues contain the mRNA for types 1 and/or 2 5 -reductase, an enzyme that converts testosterone to the very potent metabolite, dihydrotestosterone. During the past several decades, it has become quite apparent that androgens exert a significant influence on the structural organisation, functional activity, and/or pathological features of many ocular tissues, including the lacrimal gland, meibomian gland, conjunctiva, cornea, lens, uvea, and/or retina. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] The nature of this hormone action appears to involve the regulation of such ocular factors as glandular morphology, gene expression, protein synthesis and secretion, lipid production, tear film stability, immune function, epithelial cell mitosis, aqueous outflow pathway characteristics, intraocular pressure, and vascular permeability. Methods-Human1-5 10 13-16 In addition, androgens have been proposed as a topical therapy for such conditions as aqueous deficient and evaporative dry eye syndromes, corneal wound healing, and glaucoma. However, despite these findings, very little information exists concerning the precise target cells for androgen action, the specific ocular processes controlled by these hormones, or the mechanisms underlying androgen-eye interactions in humans.The mechanism(s) by which androgens act on the human eye most likely involves the local, intracrine synthesis of these hormones from adrenal sex steroid precursors (that is, dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEA-S)) and a consequent androgen association with saturable, high aYnity, and steroid specific receptors in ocular tissues. 19The rationale for this hypothesis is twofold. Firstly, a large proportion of androgens in men, and the majority of these hormones in women, are produced in peripheral tissues from adrenal precursors. 18 In fact, humans and primates are unique in possessing adrenal glands that secrete large amounts of DHEA and DHEA-S, which are then converted into potent androgens and oestrogens by steroidogenic enzymes in peripheral sites and thereby permit target tissues to adjust the formation and metabolism of sex steroids to local requirements. 18 20 Secondly, androgen receptors, which are members of the steroid/thyroid hormone/retinoic acid family of ligand activated transcription factors, appear to mediate almost all of the "classic" actions ...

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“…There are several hypotheses about the effect of progestagens in the treatment for SIPS. Progestagens appear to have angiostatic activities (Yamamoto et al 1994). In addition, Arbeiter (1975) suggested that the anti-oestrogen effect of progestagens inhibits haemorrhage resulting from increased capillary permeability in the endometrium (Arbeiter 1975).…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment for Subinvolution of Placental Sites in the Bitch with Low Oral Doses of Progestagen

Voorhorst

Brederode

Albers-Wolthers

et al. 2013

Reprod Domestic Animals

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Subinvolution of placental sites (SIPS) is the major cause of persistent sanguineous vaginal discharge after parturition in the bitch. Spontaneous remission is common but may take several months, and hence, medical therapy to end the discharge is often requested. In this retrospective study, we evaluated the effect of treatment for SIPS with low oral doses of a progestagen. Nine bitches with SIPS, but otherwise clinically healthy, were found in the computer database of the Department of Clinical Sciences of Companion Animals. Seven of these bitches were treated with low oral doses of a progestagen (megestrol acetate, 0.1 mg/kg body weight (bw) once daily for the 1st week, then 0.05 mg/kg bw once daily for the 2nd week). The other two bitches were untreated. Treatment results were evaluated by a telephone questionnaire. Progestagen treatment was successful in all of the treated dogs; sanguineous vaginal discharge stopped within the treatment period. One of the two untreated dogs remained symptomatic until the next oestrus, approximately 120 days after parturition, and the other remained symptomatic until 6 weeks before the start of the next pro-oestrus, 270 days after parturition. No side effects of the progestagen treatment were observed. Subsequent gestations, parturitions and puerperal periods of 5 mated bitches were uneventful. One bitch did not become pregnant after mating. In conclusion, the results of this study indicate that oral administration of low doses of progestagen for 2 weeks is effective in stopping persistent sanguineous vaginal discharge in bitches with SIPS, with neither side effects nor reduced subsequent fertility.

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Angiostatic activities of medroxyprogesterone acetate and its analogues

Cited by 55 publications

References 19 publications

Use of the levonorgestrel-releasing intrauterine device for the symptomatic treatment of uterine myomas

Use of the levonorgestrel-releasing intrauterine device for the symptomatic treatment of uterine myomas

Identification of androgen receptor protein and 5alpha -reductase mRNA in human ocular tissues

Successful Treatment for Subinvolution of Placental Sites in the Bitch with Low Oral Doses of Progestagen

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