Angiosome based time series analysis of deep tissue perfusion using diffuse speckle contrast analysis

Abstract

An angiosome is a three dimensional volume of biological tissue which a specific artery governs. Although proven useful for vascular surgery, the direct relationship between arterial flow and microcirculation in specific angiosome remains controversial. Here, we present new optical approach, a four-channel diffuse speckle contrast analysis (DSCA) which can simultaneously measure blood perfusion at different foot area. Based on the hypothesis that same angiosome will support similar low frequency oscillation, we investigated cross-correlation among different DSCA channels. Our preliminary results show that the LFO signal from the channel closest to posterior tibial artery is leading the signal from the other channels.

Diffuse Speckle Contrast Analysis (DSCA) for Deep Tissue Blood Flow Monitoring

“…The low frequency oscillation (LFO) inherent in microcirculation, caused by slow modulation of sphincters between arteriole and capillary, contains important information regarding vascular health, which in turn relates to tissue viability. It is regretful that not much large-scale multi-channel BFI studies have been seen in the literature yet, although some proof-of-concept work related to angiosome concept does exist [58].…”

“…One important concept for real-time perfusion monitoring during angioplasty is angiosome , which refers to a 3-dimensional tissue volume that a particular branch of artery is supplying oxygen and nutrients to. This rather new concept in anatomy and physiology is still debatable, and Yeo et al has attempted to validate the concept by comparing between inter-and intra-angiosome correlations of low frequency oscillation (LFO) in microcirculation [58]…”