Angioscopic Ulcerated Plaques in the Femoropopliteal Artery Associated with Impaired Infrapopliteal Runoff

Yamaguchi, Takahiro; Yamazaki, Takanori; Yoshida, Haruhiko; Hayashi, Ou; Yahiro, Ryosuke; Nakao, Kazuhiro; Okai, Tsukasa; Ehara, Shoichi; Izumiya, Yasuhiro; Yoshiyama, Minoru

doi:10.1016/j.jvir.2021.10.013

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…That was also suggested by Hehrlein et al [25] who found more extensive neointimal hyperplasia after balloon dilation of the femoral artery in dogs with poor outflow. Yamaguchi T et al [26] also found an impact of runoff on the atherosclerotic burden in the femoropopliteal region, observing more ulcerated plaques in patients with poor runoff. Interestingly, Kaczmarczyk et al [27] found a negative correlation between the blood flow velocity and the treatment outcome of endovascular procedures conducted on the infrainguinal arteries.…”

Section: Discussionmentioning

confidence: 90%

Prognostic Factors for Restenosis of Superficial Femoral Artery after Endovascular Treatment

Boc,

Kozak,

Eržen

et al. 2023

JCM

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High incidence of superficial femoral artery (SFA) restenosis after percutaneous transluminal angioplasty (PTA) poses a persistent challenge in peripheral arterial disease (PAD) treatment. We studied how the patients‘ and lesions’ characteristics, thrombin generation, overall haemostatic potential (OHP), and single nucleotide polymorphisms (SNPs) of the NR4A2 and PECAM1 genes affected the likelihood of restenosis. In total, 206 consecutive PAD patients with limiting intermittent claudication due to SFA stenosis who were treated with balloon angioplasty with bailout stenting when necessary were included. Patients’ clinical status and patency of the treated arterial segment on ultrasound examination were assessed 1, 6, and 12 months after the procedure. Restenosis occurred in 45% of patients, with less than 20% of all patients experiencing symptoms. In the multivariate analysis, predictors of restenosis proved to be poor infrapopliteal runoff, higher lesion complexity, absence of treated arterial hypertension, delayed lag phase in thrombin generation, and higher contribution of plasma extracellular vesicles to thrombin concentration. Poor infrapopliteal runoff increased the risk of restenosis in the first 6 months, but not later. The negative effect of poor infrapopliteal runoff on SFA patency opens questions about the potential benefits of simultaneous revascularisation of below-knee arteries along with SFA revascularisation.

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Section: Discussionmentioning

confidence: 90%

Prognostic Factors for Restenosis of Superficial Femoral Artery after Endovascular Treatment

Boc,

Kozak,

Eržen

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

Revealing Mechanisms of Atherosclerosis and Atherosclerotic Diseases Using Angioscopy

Komatsu,

Higuchi,

Takahashi

et al. 2024

J Jpn Coll Angiol

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We have developed a non-obstructive general angioscopy (NOGA) applied for any vessel size. Frequent spontaneously ruptured aortic plaques in the aorta are implicated in organ dysfunction leading to aging. We demonstrated the progression and rupture of plaques via innate immune response involving cholesterol crystals by in situ NOGA studies. Furthermore, NOGA has advanced the identification of detailed endothelial injuries in acute aortic dissections and their application in treatment. NOGA is valuable for the assessment and new therapies for atherosclerotic disease.

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Angioscopic Ulcerated Plaques in the Femoropopliteal Artery Associated with Impaired Infrapopliteal Runoff

Cited by 2 publications

References 23 publications

Prognostic Factors for Restenosis of Superficial Femoral Artery after Endovascular Treatment

Prognostic Factors for Restenosis of Superficial Femoral Artery after Endovascular Treatment

Revealing Mechanisms of Atherosclerosis and Atherosclerotic Diseases Using Angioscopy

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