Angiosarcomatous component in gliosarcoma: case report and consideration of diagnostic challenge and hemorrhagic propensity

Jiang, Nancy; Larrazabal, Ramiro; Alsunbul, Waleed; Lu, Jian‐Qiang

doi:10.7555/jbr.33.20190080

Cited by 5 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are isocitrate dehydrogenase (IDH) wild-type glioblastomas characterized by a biphasic tissue pattern of sarcomatous and gliomatous areas. Compared with other glioblastoma subtypes, gliosarcomas containing more sarcomatous components and exhibiting more severe angioinvasive or angiosarcomatous features are considered to be at a greater risk of intratumoral bleeding [ 2–4 ]. The presence of abnormal vascular structures is common in tumoral tissue, although low-flow angiostructures associated with venous ectasia rarely increase the risk of intratumoral hemorrhage.…”

Section: Introductionmentioning

confidence: 99%

Venous ectasia preceding intra-tumoral hemorrhage in a case of gliosarcoma with transverse sinus involvement

Lee

Kim

Hwang

et al. 2023

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Although intratumoral hemorrhage is common in patients with malignant brain tumors, reports on its clinical course are scarce. This report presents a rare case of a patient with intratumoral hemorrhage with gliosarcoma invading the venus sinus. This invasion and a small draining vein were observed at diagnosis. Magnetic resonance imaging performed 1 week later showed new-onset venous ectasia, which caused intratumoral hemorrhage. This case provides insight into the mechanisms underlying intratumoral hemorrhage and highlights the emergence of new intratumoral vasculature as a potential warning sign for hemorrhage.

show abstract

Section: Introductionmentioning

confidence: 99%

Venous ectasia preceding intra-tumoral hemorrhage in a case of gliosarcoma with transverse sinus involvement

Lee

Kim

Hwang

et al. 2023

Journal of Surgical Case Reports

View full text Add to dashboard Cite

show abstract

“…showed that the expression of Slug, Twist, matrix metalloproteinase (MMP)‐2, and MMP‐9 was characteristic of mesenchymal tumor areas of gliosarcomas, suggesting that similar EMT mechanisms in epithelial neoplasms are involved in mesenchymal differentiation in gliosarcoma 5 . There are numerous reports on the types of mesenchymal components found in gliosarcoma, such as fibrosarcoma and malignant fibrous histiocytoma, with the occasional presence of smooth muscle, endothelial, chondroid or osseous elements 6,7 . However, there are fewer reports on the types of glial components, such as glioblastoma, ependymoma, and oligodendroglioma 2,8,9 .…”

Section: Introductionmentioning

confidence: 99%

“…5 There are numerous reports on the types of mesenchymal components found in gliosarcoma, such as fibrosarcoma and malignant fibrous histiocytoma, with the occasional presence of smooth muscle, endothelial, chondroid or osseous elements. 6,7 However, there are fewer reports on the types of glial components, such as glioblastoma, ependymoma, and Correspondence: Yoshihisa Matsumoto, MD, PhD, Department of Neurosurgery, St Mary's Hospital, 422 Tsubukuhonnmachi, Kurume, Fukuoka 8308543, Japan. Email: fwip4873@nifty.com *Yusuke Otsu and Yoshihisa Matsumoto have made equal contribution to the paper.…”

Section: Introductionmentioning

confidence: 99%

Gliosarcoma with unusual glial components: Two case reports

et al. 2022

View full text Add to dashboard Cite

Gliosarcoma is characterized by the presence of alternating lesions of glial and mesenchymal components. Although many mesenchymal components have been reported, there are few reports on glial components. We here report two cases of gliosarcoma. Case 1 was a 42‐year‐old woman with right hemiparesis and motor aphasia. Magnetic resonance imaging (MRI) identified a tumor in the left frontal lobe. Pathological analysis of the tumor removal specimen revealed gliosarcoma, with a glial component resembling pleomorphic xanthoastrocytoma. Postoperatively, radiotherapy and chemotherapy were conducted, and the patient was symptom‐free over 12 months after surgery. Case 2 was a 67‐year‐old woman with a consciousness disorder and left hemiparesis. MRI revealed a tumor in the right frontal lobe. Pathological analysis of the first tumor removal specimen identified gliosarcoma, with a glial component characterized by large tumor cells. Additionally, the Ki‐67 labeling index of the glial component was greater than that of the mesenchymal component, and molecular genetic analysis disclosed a mutation in the telomerase reverse transcriptase (TERT) gene (TERT). Chemotherapy and radiotherapy were performed. Four months later, MRI revealed recurrence, and the second surgery was performed. Pathological analysis revealed giant cell glioblastoma without TERT mutation. The patient died due to tumor progression 12 months after the first surgery. It is essential to continue histopathological evaluation of glial components, and further genetic evaluation on gliosarcoma is required.

show abstract

NIR-II-Triggered Composite Nanofibers to Simultaneously Achieve Intracranial Hemostasis, Killing Superbug and Residual Cancer Cells in Brain Tumor Resection Surgery

Yang

Ding

et al. 2022

Adv. Fiber Mater.

View full text Add to dashboard Cite

Angiosarcomatous component in gliosarcoma: case report and consideration of diagnostic challenge and hemorrhagic propensity

Cited by 5 publications

References 11 publications

Venous ectasia preceding intra-tumoral hemorrhage in a case of gliosarcoma with transverse sinus involvement

Venous ectasia preceding intra-tumoral hemorrhage in a case of gliosarcoma with transverse sinus involvement

Gliosarcoma with unusual glial components: Two case reports

NIR-II-Triggered Composite Nanofibers to Simultaneously Achieve Intracranial Hemostasis, Killing Superbug and Residual Cancer Cells in Brain Tumor Resection Surgery

Contact Info

Product

Resources

About