Angiosarcoma treated with radiotherapy: impact of tumor type and size on outcome

Sasaki, Ryohei; Soejima, Toshinori; Kishi, Kazushi; Imajo, Yóshinari; Hirota, Saeko; Kamikonya, Norihiko; Murakami, Masao; Kawabe, Takao; Endo, Yasuo; Matsumoto, Akira; Sugimura, Kazuo

doi:10.1016/s0360-3016(01)02753-5

Cited by 103 publications

(90 citation statements)

References 18 publications

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“…Further studies are required to confirm these preliminary findings. Despite intensive therapies, local recurrences in patients with angiosarcoma of the scalp and face are frequent, ranging in frequency from 35% to 86% [7,9,13]. For local therapy, several authors indicated that radiotherapy as well as the combination of surgery and radiotherapy were significantly associated with improved LC in patients with angiosarcoma of the scalp and face [1,7,9,14].…”

Section: Discussionmentioning

confidence: 99%

“…In order to reduce the marginal and out-field recurrence, other techniques, such as intensity-modulated radiotherapy and high dose rate brachytherapy with a surface mould technique, may be necessary to achieve optimal results [15,16]. Several previous studies have suggested potential prognostic factors associated with tumour size, tumour type, age and radiotherapy use in patients with angiosarcoma of the scalp and face [2,7,13,14,17]. In the current study, concerning patient characteristics, PS and number of tumours were independent prognostic factors for OS.…”

Section: Angiosarcoma Of the Scalp And Facementioning

confidence: 99%

“…rIL-2 activates lymphokine-activated killer cells and natural killer (NK) cells, which subsequently injure vascular endothelial cells by adhering to the cells and causing their lysis [19]. Several reports have indicated that a combination of radiotherapy plus rIL-2 may produce an addictive sensitising effect [9,13]. Ohguri et al [9] found that arterial or intratumoral administration combined with systemic administration of rIL-2 resulted in better distant metastasis-free survival rates.…”

Section: Angiosarcoma Of the Scalp And Facementioning

confidence: 99%

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Treatment and prognosis of angiosarcoma of the scalp and face: a retrospective analysis of 48 patients

Ogawa

Takahashi²,

Asato³

et al. 2012

The British Journal of Radiology

102

123

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Objective: The objective of this study was to retrospectively analyse the treatment results of clinically localised angiosarcoma of the scalp and face. Methods: The records of 48 patients who were treated between 1987 and 2009 were reviewed. single modality or a combination of surgery, radiotherapy, chemotherapy and immunotherapy were administered. The median follow-up of all 48 patients was 13.7 months (range 2.5-105.9 months). Results: At the time of analysis, 45 of 48 patients (93.8%) had disease recurrences, and the lung was the most frequent site for recurrence (37 patients). In multivariate analysis, performance status (PS) and number of tumours were significant predictors of lungmetastasis-free (LMF) rate. For patients with multifocal tumours, chemotherapy use significantly decreased the LMF rate (p50.0072). The 2-year actuarial overall survival (OS), progression-free survival and local control rates in all 48 patients were 22.1%, 10.7% and 46.3%, respectively. In multivariate analysis, PS, number of tumours, surgery and radiotherapy were significant prognostic factors for OS. Patients treated with both surgery and radiotherapy (2-year OS: 45.8%) had a significantly more favourable OS (p,0.0001) than patients treated with either surgery or radiotherapy (2-year OS: 11.1%) and patients treated with neither surgery nor radiotherapy (2-year OS: 0%). Conclusions: Our results indicated that PS and number of tumours were significant predictors for developing lung metastases. Our results also indicated that PS, number of tumours, surgery use and radiotherapy use were independent prognostic factors for OS. Multimodal treatments including surgery and radiotherapy were effective in improving OS for patients with these tumours. Advances in knowledge: Multimodal treatments including surgery and radiotherapy are effective in improving overall survival for patients with angiosarcoma of the scalp and face.

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Section: Discussionmentioning

confidence: 99%

Section: Angiosarcoma Of the Scalp And Facementioning

confidence: 99%

Section: Angiosarcoma Of the Scalp And Facementioning

confidence: 99%

See 1 more Smart Citation

Treatment and prognosis of angiosarcoma of the scalp and face: a retrospective analysis of 48 patients

Ogawa

Takahashi²,

Asato³

et al. 2012

The British Journal of Radiology

102

123

View full text Add to dashboard Cite

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“…It has been reported that angiosarcoma cells are LAK-sensitive, and that LAK cells suppress tumor growth (14). Indeed, Sasaki et al (15) demonstrated that rIL-2 administration appeared to suppress the development of distant metastases. Rosenberg and Lotze (16) suggested that systemic administration of high doses of rIL-2, in combination with LAK cells, is highly effective.…”

Section: Vs 44 Months)mentioning

confidence: 99%

Long-term Survival of a Patient with Splenic Angiosarcoma after Resection, High-dose Chemotherapy, and Autologous Peripheral Blood Stem Cell Transplantation

et al. 2010

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A 48-year-old woman was admitted to our hospital in 2003, complaining of weight loss. Complete blood cell count revealed thrombocytopenia. Abdominal CT demonstrated marked splenomegaly. FDG-PET revealed a hot spot in the whole spleen. A splenectomy was performed. Histological examination was typical for angiosarcoma. Adjuvant chemotherapy was given, and high-dose chemotherapy with autologous peripheral blood stem cell transplantation was performed. Thrombocytopenia developed again in 2008. CT scan showed a hepatic tumor. A fine-needle biopsy of the liver revealed the first relapse. Despite hepatic lobectomy, radiofrequency ablations and administration of recombinant interleukin-2, she died from respiratory failure in 2009.

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“…1,2 When radiotherapy (RT) is given as the main treatment, median survival is only 8 months. 3 Almost half (43%) of angiosarcomas originate from the skin of the head and neck. 1,2 Compared with truncal and extremity angiosarcoma, the prognosis of cutaneous angiosarcoma (CAS) of the head and neck is even worse.…”

Section: Introductionmentioning

confidence: 99%

Treatment of cutaneous angiosarcoma of the scalp and face in the Chinese patients: local experience at a regional hospital in Hong Kong

Chow

Kwan

2018

Hong Kong Med J

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Angiosarcoma treated with radiotherapy: impact of tumor type and size on outcome

Cited by 103 publications

References 18 publications

Treatment and prognosis of angiosarcoma of the scalp and face: a retrospective analysis of 48 patients

Treatment and prognosis of angiosarcoma of the scalp and face: a retrospective analysis of 48 patients

Long-term Survival of a Patient with Splenic Angiosarcoma after Resection, High-dose Chemotherapy, and Autologous Peripheral Blood Stem Cell Transplantation

Treatment of cutaneous angiosarcoma of the scalp and face in the Chinese patients: local experience at a regional hospital in Hong Kong

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