Angiosarcoma Thyroid: Case Report and Review of Literature

Abstract

Objective: To describe a rare case of angiosarcoma thyroid in Indian subcontinent with its successful management. Case report: A 60-year-old male with swelling in neck for 20years with sudden increase in the size during last 3 months. Fine needle aspiration cytology suggested anaplastic carcinoma. The patient underwent total thyroidectomy with central and lateral neck dissection. On histopathology, the diagnosis of angiosarcoma was suspected. Immunohisto chemistry confirmed the diagnosis of angiosarcoma. Post-operative chemoradiation was given with no recurrence at 10 months of follow up. Conclusion: Though rare, angiosarcoma should be included as differential diagnosis in cases of long standing goiters with recent rapid increase in size. Immunohistochemistry is crucial for diagnosis and should be considered in these patients. Early and prompt diagnosis will help in providing curative treatment in such patients.

Primary diagnosis of angiosarcoma by fine needle aspiration: Lessons learned from 3 cases

“…21 The majority of cases of primary thyroid angiosarcomas have been reported in the Alps region in Europe [22][23][24] where these comprise approximately 10-15% of thyroid malignancies. 20,25 In our case, the presentation of this disease in a patient from Liberia could suggest similar risk factors of endemic iodine-deficient goiter. According to the World Health Organization, most thyroid angiosarcomas are epithelioid as in our case.…”

“…Therefore, the first symptoms noted are often dyspnea and anemia . The majority of cases of primary thyroid angiosarcomas have been reported in the Alps region in Europe where these comprise approximately 10–15% of thyroid malignancies . In our case, the presentation of this disease in a patient from Liberia could suggest similar risk factors of endemic iodine‐deficient goiter.…”