Angiosarcoma of the uterus following radiotherapy for squamous cell carcinoma of the cervix

Morrel, Beth; Mulder, A. F. P.; Chadha, Seema; Tjokrowardojo, A. J. Subandono; Wijnen, Johannes A.

doi:10.1016/0028-2243(93)90269-i

Cited by 19 publications

(7 citation statements)

References 23 publications

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“…Uterine sarcomas other than leiomyosarcomas and endometrial [4] and Cardinale et al [5], only 24 cases of uterine angiosarcoma have ever been published in the English-speaking literature. Since routine immunohistochemical investigation was introduced in the early 1980s, only 15 cases [4,5,[7][8][9][10][11][12][13][14][15] have been documented using this technique in addition to morphological analysis. In the case we describe, angiosarcoma was microscopically identified by the freely anastomosing vascular channels, but also by positive immunohistochemical staining for endothelial cell antigens such as CD31, CD34, and von Willebrand factor.…”

Section: Discussionmentioning

confidence: 99%

Cardiac and gingival metastasis after total abdominal hysterectomy with bilateral salpingo-oophorectomy for primary uterine epithelioid angiosarcoma: case report and review of the literature

et al. 2009

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Uterine epithelioid angiosarcomas are extremely rare; only 24 cases have been documented worldwide. We present a unique case of cardiac and gingival metastases developing 4 years after total abdominal hysterectomy with bilateral salpingo-oophorectomy for primary uterine epithelial angiosarcoma. Initial treatment remains total abdominal hysterectomy with bilateral salpingo-oophorectomy. Limited distant metastases may be surgically resected in selected cases in order to improve quality of life or to prevent sudden death in untreated patients. Optimal chemotherapy regimens must be determined.

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Section: Discussionmentioning

confidence: 99%

Cardiac and gingival metastasis after total abdominal hysterectomy with bilateral salpingo-oophorectomy for primary uterine epithelioid angiosarcoma: case report and review of the literature

et al. 2009

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“…The presence of intracytoplasmic vacuoles in the form of minute lumens with erythrocytes favors endothelial cell differentiation. Electron microscopy may also contribute to the diagnosis if Weibel-Palade bodies can be verified [12–15]. …”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of the tumor is obscure, although Morrel et al [12] presented a case of a 61-year-old woman who developed a uterine angiosarcoma 6.5 years following radiotherapy for a squamous cell carcinoma of the uterine cervix. Others incriminated chemotherapy, chronic lymphedema, chronic steroid use, chemical exposure and tumor collision or tumor transformation as being responsible for the tumor development [1, 2, 14, 16].…”

Section: Discussionmentioning

confidence: 99%

Low-Grade Uterine Epithelioid Hemangioendothelioma Presented as a Submucosal Leiomyoma during Labor

Koutsopoulos

Sivridis

Tsikouras

et al. 2013

Case Reports in Pathology

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With the exception of leiomyomas, soft tissue tumors of the uterine corpus are not common. This is particularly true for vascular neoplasms, with the epithelioid hemangioendothelioma being a curiosity; not more than twenty-two cases of malignant hemangioendotheliomas have been reported in the literature so far, all of which were high-grade hemangioendotheliomas (hemangiosarcomas). We present herewith a unique case of low-grade epithelioid hemangioendothelioma of the uterus in a pregnant woman aged 29 years. The clinical, histological, and immunohistochemical characteristics of this entity, together with its differential diagnosis, are discussed.

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“…La localización somática es inusual y se han reportado casos esporádicos de localización visceral en pulmón, glándula mamaria, pleura e hígado (2). En el cuerpo uterino se han publicado 33 casos (2,(6)(7)(8)(9)(11)(12)(13)(14), incluido el presente, con características epidemiológicas específicas que incluyen presentación en mujeres en su mayoría posmenopáusicas con un rango de edad que oscila entre 17 y 81 años (edad promedio de 52 años); 7 casos, incluido el presente, han sido descritos en mujeres premenopausicas y con mayor sobrevida.…”

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Angiosarcoma primario uterino: revisión de la literatura y presentación de caso

et al. 2012

Rev. chil. obstet. ginecol.

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RESUMENAntecedentes: Los angiosarcomas son infrecuentes y corresponden a menos del 1% de tumores de tejidos blandos, pueden presentarse en cualquier localización fundamentalmente en la piel. El angiosarcoma primario uterino fue por primera vez reportado en 1902 por Silberberg con informes ulteriores esporádicos que suman un total de 33 casos incluyendo el presente. Objetivo: Exponer un caso diagnosticado en el Departamento de Patología de la Universidad Industrial de Santander (Bucaramanga-Colombia), y revisar la literatura de los casos previamente descritos. Caso clínico: Paciente de 25 años, con 2 años de evolución de menometrorragias y dolor pélvico crónico. Se realiza ablación endometrial encontrándose tumor maligno de endometrio pobremente diferenciado, infiltrante, el cual no es posible categorizar. Se efectúa una histerectomía ampliada, salpingooforectomía bilateral, linfadenectomía pélvica y omentectomía. El examen microscópico reveló lesión tumoral pobremente diferenciada compatible con un angiosarcoma uterino de alto grado. PALABRAS CLAVE: Angiosarcoma uterino primario, inmunohistoquímica SUMMARYBackground: Angiosarcomas are rare and account for less than 1% of soft tissue tumors can occur at any location primarily in the skin. The primary uterine angiosarcoma was first reported in 1902 by Silberberg with sporadic subsequent reports, with a total of 33 cases including the present. Objective: To present a case diagnosed in the Department of Pathology, Universidad Industrial de Santander (Bucaramanga, Colombia) and review the literature of the cases previously described. Case report: A 25 years old woman, with 2 years of chronic pelvic pain and menometrorrhagia. Endometrial ablation is performed and an endometrial malignancy was found, poorly differentiated and infiltrating, which is not possible to categorize. It makes an extended hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy, and omentectomy. Microscopic examination revealed poorly differentiated tumor, compatible with a high-grade uterine angiosarcoma.

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Angiosarcoma of the uterus following radiotherapy for squamous cell carcinoma of the cervix

Cited by 19 publications

References 23 publications

Cardiac and gingival metastasis after total abdominal hysterectomy with bilateral salpingo-oophorectomy for primary uterine epithelioid angiosarcoma: case report and review of the literature

Cardiac and gingival metastasis after total abdominal hysterectomy with bilateral salpingo-oophorectomy for primary uterine epithelioid angiosarcoma: case report and review of the literature

Low-Grade Uterine Epithelioid Hemangioendothelioma Presented as a Submucosal Leiomyoma during Labor

Angiosarcoma primario uterino: revisión de la literatura y presentación de caso

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