Angiosarcoma of the mandible: Metastasis from a primary tumor of the right atrium of the heart

Ramadhan, Anwar; Willén, Helena; Thor, Andreas

doi:10.4236/crcm.2013.21015

Cited by 7 publications

(16 citation statements)

References 18 publications

(36 reference statements)

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“…Primary ASs are often misdiagnosed as other lesions because of their rarity. Our case was initially reported as sclerosing hemangioma, and while a CT scan supported a facial artery aneurysm, other missed diagnoses include pyogenic granuloma 1 . Delayed or missed diagnosis is associated with poor treatment outcome 1 .…”

Section: Discussionmentioning

confidence: 74%

“…Angiosarcoma (AS), also known as malignant hemangioendothelioma, is a rare and aggressive malignant tumor of endothelial cells of vascular or lymphatic origin. These tumors typically have a poor prognosis, and they represent less than 1% of all malignant tumors 1 and between 1% to 2% of soft tissue sarcomas 2 3 4 . About 50% to 52% of all ASs occur in the head and neck 3 5 and are found predominantly on the scalp and face of elderly men 2 5 .…”

Section: Introductionmentioning

confidence: 99%

“…AS is extremely rare in the oral cavity and salivary glands, accounting for 1% of all ASs reported in the literature 1 4 . Although the tumor can occur in any location, the most common sites are soft tissue, skin 6 , trunk, and limbs 7 .…”

Section: Introductionmentioning

confidence: 99%

“…There is inconsistency in the data on age-related tumor involvement because some authors postulate that older patients have a greater propensity for AS, while others suggest that AS favors those of a younger age 7 . In general, all age groups can be affected, though it is prevalent among older white men and often presents as a cutaneous lesions 1 . The median age of those who develop AS, according to Yang et al 3 , is 60 to 70 years, and the mean age, according to Fanburg-Smith et al 8 , is 55 years.…”

Section: Introductionmentioning

confidence: 99%

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Primary oral soft tissue angiosarcoma of the cheek: a case report and literature review

Fomete

Samaila

Edaigbini

et al. 2015

J Korean Assoc Oral Maxillofac Surg

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Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary oral soft tissue angiosarcoma of the cheek: a case report and literature review

Fomete

Samaila

Edaigbini

et al. 2015

J Korean Assoc Oral Maxillofac Surg

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“…[ 10 11 ] Ramadhan et al . [ 12 ] reported a case of right atrial tumor metastasizing to lung, liver and mandible. Erpolat et al .…”

Section: Discussionmentioning

confidence: 99%

¹⁸ F-fluoro-deoxyglucose positron emission tomography-computed tomography in initial assessment and diagnosis of right atrial angiosarcoma with widespread visceral metastases: A rare case report and review of the literature

2015

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Cardiac angiosarcoma is the most common primary cardiac sarcoma in adults. Primary cardiac tumors are rare and have nonspecific clinical presentation, thus making its diagnosis challenging. Clinically, patients present with advanced disease demonstrating metastatic disease at initial presentation itself. It commonly metastasizes to lung, liver, brain, and bone; however metastases to lymph nodes, adrenal glands, spleen and skin has also been seen. We describe a case of right atrial angiosarcoma with extensive visceral metastases involving brain, lungs, liver, pancreas, kidney, and lymph nodes, demonstrated on contrast-enhanced 18F-fluoro-deoxyglucose positron emission tomography-computed tomography (FDG PET-CT). To the best of our knowledge metastases to pancreas and kidney have not been reported so far in the literature. With our report, we emphasize on the initial use of FDG PET-CT in workup of cardiac angiosarcoma for accurate staging and prognostication of this disease.

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Right atrial epithelioid angiosarcoma with multiple pulmonary metastasis confirmed by multimodality imaging-guided pulmonary biopsy

et al. 2018

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Rationale:Primary cardiac tumors are very rare, and angiosarcoma accounts for about 33% of all primary malignant cardiac tumors. Primary cardiac epithelioid angiosarcoma is a highly aggressive and difficult to diagnose tumor, with early systemic metastasis and poor prognosis.Patient concerns:A 35-year-old Han male experienced sudden severe palpitation and moderate dyspnea. The patient received a whole body F-18 fluoro-deoxyglucose positron emission tomography (18F-FDG PET)/computed tomography (CT) scan, the scan showed a large mass in the right atrium (RA) and numerous pulmonary nodules in both lungs.Diagnoses:The patient was diagnosed as right atrial epithelioid angiosarcoma with multiple pulmonary metastasis by pulmonary biopsy through CT-guided percutaneous transthoracic fine needle aspiration.Interventions:The patient received a cycle of chemotherapy with docetaxel and gemcitabine, followed by another cycle with epirubicin and ifosfamide.Outcomes:The chemotherapy was ineffective. After the two cycles, the bilateral pleural effusion steadily increased, the patient had severe dyspnea and palpitation, and died three weeks later, with an overall survival of 2.5 months.Lessons:Primary angiosarcoma of heart is a very rare and aggressive disease, and its diagnosis and treatment are difficult. Most patients may have systemic metastasis at diagnosis, and have a very short survival without surgical resection. Hence, early diagnosis and surgical resection is extremely important to treat this disease.

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Angiosarcoma of the mandible: Metastasis from a primary tumor of the right atrium of the heart

Cited by 7 publications

References 18 publications

Primary oral soft tissue angiosarcoma of the cheek: a case report and literature review

Primary oral soft tissue angiosarcoma of the cheek: a case report and literature review

¹⁸ F-fluoro-deoxyglucose positron emission tomography-computed tomography in initial assessment and diagnosis of right atrial angiosarcoma with widespread visceral metastases: A rare case report and review of the literature

Right atrial epithelioid angiosarcoma with multiple pulmonary metastasis confirmed by multimodality imaging-guided pulmonary biopsy

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Angiosarcoma of the mandible: Metastasis from a primary tumor of the right atrium of the heart

Cited by 7 publications

References 18 publications

Primary oral soft tissue angiosarcoma of the cheek: a case report and literature review

Primary oral soft tissue angiosarcoma of the cheek: a case report and literature review

18 F-fluoro-deoxyglucose positron emission tomography-computed tomography in initial assessment and diagnosis of right atrial angiosarcoma with widespread visceral metastases: A rare case report and review of the literature

Right atrial epithelioid angiosarcoma with multiple pulmonary metastasis confirmed by multimodality imaging-guided pulmonary biopsy

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¹⁸ F-fluoro-deoxyglucose positron emission tomography-computed tomography in initial assessment and diagnosis of right atrial angiosarcoma with widespread visceral metastases: A rare case report and review of the literature