Angiosarcoma of the head and neck: Review of 11 cases

Panje, William R.; Moran, William J.; Bostwick, David G.; Kitt, Victor V.

doi:10.1288/00005537-198612000-00012

Cited by 58 publications

(40 citation statements)

References 7 publications

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“…The prognosis of cutaneous angiosarcoma of the scalp and face is poor with a 5-year survival rate of 10±22% and a mean survival length of 24 months (Maddox and Evans 1981;Panje et al 1986;Caldwell et al 1995;Wanebo et al 1992). Spontaneous regression is exceptional (Cerroni et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Angiosarcoma of the scalp: treatment with liposomal doxorubicin and radiotherapy

Wollina

Füller

Graefe

et al. 2001

Journal of Cancer Research and Clinical Oncology

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Section: Introductionmentioning

confidence: 99%

Angiosarcoma of the scalp: treatment with liposomal doxorubicin and radiotherapy

Wollina

Füller

Graefe

et al. 2001

Journal of Cancer Research and Clinical Oncology

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“…Hence, the lesion is frequently misdiagnosed. Pathologists need extensive experience to diagnose and distinguish it from poorly differentiated adenocarcinoma, sarcoma and melanoma [13,14]. The samples sent for biopsy are often of areas of inflammation and ulceration, and not the actual tumor site.…”

Section: Discussionmentioning

confidence: 99%

Extensive angiosarcoma of the scalp involving the cranium

Chun

Urdang

2002

Eur J Plast Surg

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A case of angiosarcoma of the scalp involving the underlying bone is presented. Wide local excision of the scalp and full-thickness excision of the underlying calvarium and dura followed by reconstruction with latissimus dorsi free flap and skin graft was performed. Despite an initial negative frozen section of the margins, the final pathologic specimen showed microscopic involvement of the inferior margin. The positive margin was re-excised accomplished with the aid of mapping biopsies. This case demonstrates the typical nature of this rare tumor in terms of the difficulty of histologic diagnosis and surgical management.

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“…A spectrum of treatments can be found in the literature to include surgery, radiation or a combination of these. Although no modality of treatment seems superior, most authors seem to favor surgical excision as the cornerstone of treatment [1,14,22,29,34]. This contention is supported by the finding in many reports of no survivors without surgical intervention.…”

Section: Treatmentmentioning

confidence: 99%

Orbital angiosarcoma ? case report and treatment options

et al. 1997

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Abstract.Orbital angiosarcoma is an exceedingly rare subgroup of angiosarcoma. Angiosarcoma makes up less than 1% of all soft tissue sarcomas. Fifteen reported cases to date of orbital angiosarcoma demonstrate its size-dependent, aggressive, widely infiltrative nature, poor circumscription, multifocality, tendency for local recurrence, predilection for pediatric age groups, and dismal prognosis. Hufnagel and Koo [18] in 1987 eloquently and comprehensively reviewed the literature regarding this unusually rare subset of angiosarcoma. Proptosis associated with blepharoptosis was the most common presenting symptom. Further, swelling was noted in approximately one-half of the patients, and ophthalmoplegia was noted in approximately one-fourth. In addition, Hufnagel and Koo [18] reviewed the treatment options for orbital angiosarcoma. The options range from excision alone, excision followed by radiating therapy (RT), orbital exenteration, exenteration with RT and exenteration with RT and chemotherapy. They noted no apparent correlation between treatment modality and long-term outcome. Only three of the fifteen patients were noted to be alive without evidence of disease at 14 months, 1.5 years, and 2.5 years. The purpose of this paper is to document this rare case, to demonstrate the utility of en block resection with staged reconstruction and to report long-term survival.Key words: Orbit -Angiosarcoma -Reconstruction Case reportA 71-year-old male presented to the Institute for Craniofacial and Reconstructive Surgery at Providence Hospital, Southfield, Michigan in November of 1991, stating a six week history of swelling of the left side of the nose and medial canthal region. He was otherwise asymptomatic without ocular, nasal or lacrimal system-related symptoms. The patient underwent fine needle aspiration cy- En block resection of the left medial canthus, medial orbit including roof and floor, as the medial aspect of both the upper and lower eyelids was then performed. Initial reconstruction utilized a lower eyelid switch flap (Mustarde) for the first stage upper eyelid reconstruction and a forehead flap for nasal and medial canthal reconstruction. Six weeks later, second stage reconstruction was accomplished by insetting the lower eyelid switch flap into the upper eyelid defect. A nasal chondromucosal graft was then harvested, sutured into place in the lower eyelid, and a cheek flap was then raised to complete the lower eyelid reconstruction. The patient has been followed closely postoperatively, both with clinical exams and follow-up scans, and shows no evidence of recurrent nor metastatic disease at 41/2 years. DiscussionAngiosarcoma is a rare entity comprising less than 1% of all soft tissue sarcomas. The etiology of angiosarcoma has been speculatively linked to a number of elements. For example: 1) connective tissue dystrophy secondary to chronic lymphedema [27], 2) upper extremity lymphedema associated with the post-mastectomy patient [6,15,16], radiotherapy in a variety of different clinical settings [2,11,14,2...

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Angiosarcoma of the head and neck: Review of 11 cases

Cited by 58 publications

References 7 publications

Angiosarcoma of the scalp: treatment with liposomal doxorubicin and radiotherapy

Angiosarcoma of the scalp: treatment with liposomal doxorubicin and radiotherapy

Extensive angiosarcoma of the scalp involving the cranium

Orbital angiosarcoma ? case report and treatment options

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