Angiosarcoma hepático y trasplante hepático: reporte de caso y revisión de bibliografía

Huerta-Orozco, Lorena Denisse; Leonher-Ruezga, Karla Lisseth; Ramírez-González, Luis Ricardo; Hermosillo-Sandoval, José Manuel; Sandoval-Alvarado, José de Jesús; Morán-Galaviz, Rubén Eduardo

doi:10.1016/j.circir.2015.05.027

Cited by 4 publications

(2 citation statements)

References 13 publications

(14 reference statements)

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“…Environmental carcinogens, especially vinyl chloride, are associated with an increased risk of developing hepatic angiosarcoma; however, in most cases, the cause remains unknown [5]. Lesions seen on CT and MRI imaging can show increased vascularity, while others can be hypodense or even appear normal [6,7]. The overall prognosis is very poor, with an average survival of less than six months from the time of diagnosis [5].…”

Section: Discussionmentioning

confidence: 99%

Liver Transplantation in a Patient With Hepatic Angiosarcoma

Dhaliwal

Braseth

Dhindsa

et al. 2021

Cureus

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Liver transplantation (LT) is an accepted form of therapy for selected cases of malignant tumors of the liver that include primary and fibrolamellar hepatocellular carcinoma, cholangiocarcinoma limited to Klatskin distribution, neuroendocrine tumors, epithelioid hemangioendothelioma, and hepatoblastoma. This is the case of a 61-year-old previously healthy female transferred from an outside hospital for a second opinion for a liver transplant. Computed tomography of the abdomen with contrast showed cirrhosis and multiple masses with arterial enhancement in her liver. She underwent a liver biopsy that showed a low-grade vascular tumor. She underwent an exploratory laparotomy with open liver biopsy which showed no visual evidence of omental spread. The pathology was reported as a low-grade vascular lesion, which was likely a small vessel neoplasm. After denial for LT secondary to an unknown low-grade vascular tumor, she presented to our medical center. Oncology was consulted and diagnosed with her liver vascular tumors as benign with an overall favorable prognosis. She was listed for liver transplant with a model for end-stage liver disease-sodium score of 25 and developed hepatorenal syndrome type 1. She was on hemodialysis for approximately 10 weeks prior to her LT and was eventually listed for simultaneous liver and kidney transplants. She underwent an orthotopic liver transplant 10 weeks after presenting to UNMC. The amount of necrosis and the elevated mitotic rate was sufficient to classify the tumor as a Federation Nationale des Centres de Lutte le Cancer grade 3 of three angiosarcomas. She was scheduled for a living donor kidney transplant three days after her liver transplant, but it was postponed after she continued to have increased urine output that responded to a trial of diuretics with continued improvement in kidney function. She successfully completed 16 months post-LT without any known recurrence of primary angiosarcoma.

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Section: Discussionmentioning

confidence: 99%

Liver Transplantation in a Patient With Hepatic Angiosarcoma

Dhaliwal

Braseth

Dhindsa

et al. 2021

Cureus

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“…Afecta principalmente a pacientes entre la sexta y séptima década de vida, si bien el rango de edad de aparición va de los 20 a los 80 años 2 , y es más frecuente en varones (relación 3:1). El diagnóstico se realiza en necropsia en un alto porcentaje de casos (mayor del 35% en algunas series) 3 .…”

Section: Discusión Y Conclusionesunclassified

Angiosarcoma hepático: un tumor maligno infrecuente

Ramos-Lázaro

Chacón-Cid

Farina

et al. 2022

Rev Esp Casos Clin Med Intern

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Hepatic angiosarcoma as a cause of acute liver failure

Singh¹,

Mills

Asadi

et al. 2018

BMJ Case Reports

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Hepatic angiosarcoma is an extremely rare disease entity that accounts for approximately 0.1%-2% of primary liver malignancy. It is three times more common in men than women and usually affects the former in their sixth or seventh decade of life. Risk factors for the development of hepatic angiosarcoma include the use of oral contraceptives, exposure to anabolic steroids, radiation, thorium dioxide, arsenic and vinyl chloride. The prognosis of hepatic angiosarcoma is extremely poor which is attributable to early metastases to other organs, resistance to traditional chemotherapy and radiotherapy regimens and rapid progression of the tumour. Optimal management of patients is poorly demarcated due to the rarity of the tumour. We present a case series of two patients: one who passed away due to acute hepatic failure secondary to hepatic angiosarcoma and the second who underwent a liver transplantation and was subsequently diagnosed with hepatic angiosarcoma based on his explant histology.

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Angiosarcoma hepático y trasplante hepático: reporte de caso y revisión de bibliografía

Abstract: Hepatic angiosarcoma is a malignant vascular neoplasia, the potential curative option is surgery with tumour free margins. Liver transplantation remains controversial because of its poor prognosis in the short term.

Cited by 4 publications

References 13 publications

Liver Transplantation in a Patient With Hepatic Angiosarcoma

Liver Transplantation in a Patient With Hepatic Angiosarcoma

Angiosarcoma hepático: un tumor maligno infrecuente

Hepatic angiosarcoma as a cause of acute liver failure

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