Angiosarcoma associated with foreign body material: A report of three cases

Jennings, Timothy A.; Peterson, LoAnn; Axiotis, Constantine A.; Friedlaender, Gary E.; Cooke, Robin A.; Rosaí, Juan

doi:10.1002/1097-0142(19881201)62:11<2436::aid-cncr2820621132>3.0.co;2-j

Cited by 180 publications

(69 citation statements)

References 34 publications

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“…28,32,33 We observed that AS rates rose steadily among whites from 1978 through 2004, although they declined among white men in recent years. AS has been reported in association with chronic lymphoedema, 34 vascular malformations, 35 arteriovenous shunts, 36 environmental exposures, 37 xerodermal pigmentosum, 38 and retinoblastoma. 39 There are some possible explanations for the overall increase in incidence rates of AS.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous soft tissue sarcoma incidence patterns in the U.S.

Rouhani

Fletcher

Devesa

et al. 2008

Cancer

294

228

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BACKGROUND.Cutaneous soft tissue sarcomas (CSTS) are a heterogeneous group of mesenchymal neoplasms. To the authors' knowledge, no prior large, population‐based study has focused on CSTS.METHODS.Surveillance, Epidemiology, and End Results (SEER) Program incidence and relative survival rates of CSTS were analyzed according to race, sex, and histologic type using the 2002 criteria of the World Health Organization classification.RESULTS.Among residents of the 13 SEER registries, 12,114 CSTS were diagnosed from 1992 through 2004. Overall age‐adjusted CSTS incidence rates were highest among blacks (30.8 per 1,000,000 person‐years) followed by whites (25 per 1,000,000 person‐years), and American Indians/Alaska Natives (11.2 per 1,000,000 person‐years) and were lowest among Asian/Pacific Islanders (7.7 per 1,000,000 person‐years). Kaposi sarcoma (KS) accounted for 71.1% of cases, and the rates were similarly ranked. Dermatofibrosarcoma protuberans (DFSP) rates also were highest among blacks, whereas leiomyosarcoma (LS) and angiosarcoma (AS) rates were highest among whites. The rate ratio of men to women was 25.5 for KS, 4.7 for malignant fibrous histiocytoma (MFH), 3.7 for LS, 2.0 for AS, and 0.9 for DFSP. The 5‐year relative survival rates were 99% for patients with DFSP, 89% for patients with MFH, 92% for patients with LS, and 45% for patients with AS. KS rates among men in the original 9 SEER registries increased more than 30‐fold during the 1980s before they peaked around 1991 and subsequently declined rapidly because of human immunodeficiency virus‐associated KS and highly active antiretroviral therapy. This KS pattern was evident not only among those ages 20 to 59 years but also among those ages 60 to 69 years. From 1978 through 2004, LS and AS rates among whites increased exponentially.CONCLUSIONS.CSTS rates varied markedly over time and by race, sex, and histologic type, supporting the notion that these histologic variants of CSTS areetiologically distinct. Cancer 2008. © 2008 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Cutaneous soft tissue sarcoma incidence patterns in the U.S.

Rouhani

Fletcher

Devesa

et al. 2008

Cancer

294

228

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“…Artificial implants and accidental foreign-body material are associated with occasional soft tissue sarcomas in humans, although precise figures are not available (35). It has been argued that the rate must be low because of the small number of implant-associated soft tissue sarcomas reported in the literature despite the frequent use of various implants for medical purposes (36).…”

Section: Discussionmentioning

confidence: 99%

Implanted depleted uranium fragments cause soft tissue sarcomas in the muscles of rats.

Hahn

Guilmette

Hoover

2002

Environ Health Perspect

107

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In this study, we determined the carcinogenicity of depleted uranium (DU) metal fragments containing 0.75% titanium in muscle tissues of rats. The results have important implications for the medical management of Gulf War veterans who were wounded with DU fragments and who retain fragments in their soft tissues. We compared the tissue reactions in rats to the carcinogenicity of a tantalum metal (Ta), as a negative foreign-body control, and to a colloidal suspension of radioactive thorium dioxide ((232)Th), Thorotrast, as a positive radioactive control. DU was surgically implanted in the thigh muscles of male Wistar rats as four squares (2.5 x 2.5 x 1.5 mm or 5.0 x 5.0 x 1.5 mm) or four pellets (2.0 x 1.0 mm diameter) per rat. Ta was similarly implanted as four squares (5.0 x 5.0 x 1.1 mm) per rat. Thorotrast was injected at two sites in the thigh muscles of each rat. Control rats had only a surgical implantation procedure. Each treatment group included 50 rats. A connective tissue capsule formed around the metal implants, but not around the Thorotrast. Radiographs demonstrated corrosion of the DU implants shortly after implantation. At later times, rarifactions in the radiographic profiles correlated with proliferative tissue responses. After lifetime observation, the incidence of soft tissue sarcomas increased significantly around the 5.0 x 5.0 mm squares of DU and the positive control, Thorotrast. A slightly increased incidence occurred in rats implanted with the 2.5 x 2.5 mm DU squares and with 5.0 x 5.0 mm squares of Ta. No tumors were seen in rats with 2.0 x 1.0 mm diameter DU pellets or in the surgical controls. These results indicate that DU fragments of sufficient size cause localized proliferative reactions and soft tissue sarcomas that can be detected with radiography in the muscles of rats.

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“…Most cases have an aggressive behavior with a median survival of seven months, and 5 year survival of about 35%. 5 Palliative chemotherapy for disseminated disease is hampered by toxicities and poor response rates.…”

Section: Discussionmentioning

confidence: 90%