Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma

Nathenson, Michael J.; Molavi, Diana Weedman; Aboulafia, Albert J.

doi:10.1155/2014/185323

Cited by 8 publications

(7 citation statements)

References 11 publications

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“…An important indication is that most cancers develop later in life [ 130 ]. There are proliferative disorders such as benign hemangioma that, only on very rare occasions, transform into a malignant counterpart (i.e., angiosarcoma) [ 131 , 132 ], while other lesions, such as gastric mucosal intestinal metaplasia, have a higher risk of resulting in gastric cancer (i.e., 0.25% of the cases) [ 133 ]. For the latter, endoscopic surveillance every 1 to 2 years is needed as follow-up [ 134 ].…”

Section: Discussionmentioning

confidence: 99%

Pterygium—The Good, the Bad, and the Ugly

Acker

Bogerd

Haagdorens

et al. 2021

Cells

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Pterygium is a multifaceted pathology that displays apparent conflicting characteristics: benign (e.g., self-limiting and superficial), bad (e.g., proliferative and potentially recurrent) and ugly (e.g., signs of preneoplastic transformation). The natural successive question is: why are we lacking reports showing that pterygium lesions become life-threatening through metastasis, especially since pterygium has considerable similarities with UV-related malignancies on the molecular level? In this review, we consider how our pathophysiological understanding of the benign pterygium pathology overlaps with ocular surface squamous neoplasia and skin cancer. The three UV-related disorders share the same initial insult (i.e., UV radiation) and responsive repair mechanisms to the ensuing (in)direct DNA damage. Their downstream apoptotic regulators and other cellular adaptations are remarkably alike. However, a complicating factor in understanding the fine line between the self-limiting nature of pterygium and the malignant transformation in other UV-related diseases is the prominent ambiguity in the pathological evaluation of pterygium biopsies. Features of preneoplastic transformation (i.e., dysplasia) are used to define normal cellular reactions (i.e., atypia and metaplasia) and vice versa. A uniform grading system could help in unraveling the true nature of this ancient disease and potentially help in identifying the earliest intervention point possible regarding the cellular switch that drives a cell’s fate towards cancer.

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Section: Discussionmentioning

confidence: 99%

Pterygium—The Good, the Bad, and the Ugly

Acker

Bogerd

Haagdorens

et al. 2021

Cells

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“…2,8 Interestingly, several cases of composite hemangioendotheliomas have been reported which also include areas of low- to high-grade angiosarcomas. 8,9 Despite this, while local recurrence is common, typical composite hemangioendotheliomas are less aggressive than angiosarcomas with only 1 reported case of metastasis and death. 10 Given its nebulous definition and variety of presentations, there is question as to whether hemangioendotheliomas may represent a spectrum of disease from hemangioma to angiosarcoma, more benign or aggressive variants of angiosarcomas themselves, or entirely separate entities altogether.…”

Section: Discussionmentioning

confidence: 99%

“…However, the argument has been made that these lesions would likely be classified differently now as the cellular stage of capillary hemangiomas and not true angiosarcomas. 9 Nathenson et al 9 reported a more convincing case of soft tissue angiosarcoma arising from a hemangioma in the calf of a 40-year-old woman that had been present for 10 years. Pathology of this lesion demonstrated a cavernous hemangioma with multiple areas of high-grade angiosarcoma and an area of hemangioendothelioma.…”

Section: Discussionmentioning

confidence: 99%

Malignant Conversion of Eyelid Capillary Hemangioma to Cutaneous Angiosarcoma

Heinze

Pham

Lin

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Angiosarcomas represent a rare aggressive malignancy of endothelial cell origin that carry a poor prognosis. Here, the authors report the case of a 71-year-old male presenting with a well-differentiated angiosarcoma of the right upper eyelid which arose at the site of a congenital eyelid hemangioma. The patient had undergone multiple surgical resections of the hemangioma previously without adjunctive radiation therapy. This lends evidence to the potential for malignant transformation of benign hemangiomas, and long-term monitoring of benign cutaneous vascular lesions should be considered.

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“…They exhibit hematogenous spread with the lungs being the most common site for metastasis, followed by the liver, bones, soft tissues, and lymph nodes. The pathological diagnosis of angiosarcoma depends on the grading of tumorigenic cells either of high or low grade [ 10 ]. The overall survival rate ranges from 6 to 16 months [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Angiosarcoma of Humerus – A Case Report and Literature Review

Jeyaraman¹,

Muthu²,

Prabhakar³

et al. 2021

JOCR

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Introduction: Osseous angiosarcoma is a very rare tumor of bone with aggressive behavior, propensity for recurrences, and distant metastasis. The etiology of osseous angiosarcoma is uncertain; however, specific risk factors have been recognized. The diagnosis of angiosarcoma of bone demands multimodality imaging in conjunction with histopathological and vascular marker evaluation to aptly differentiate them from other vascular tumors. Treatment of osseous angiosarcoma remains controversial. Case Report: A 53-year-old male presented with pain and swelling of the right upper 1/3rd of the arm following heaviness while lifting weight for 3 months. He had a history of significant weight loss and appetite with no history of inciting trauma or irradiation in the past. On examination, a diffuse swelling was noted in the right shoulder and right scapular aspect with varied consistency and ill-defined borders and margins. The skin over the swelling was stretched and shiny with dilated engorged veins over it. The plain radiograph of the right shoulder with humerus revealed a large expansile lytic soft-tissue mass in the right proximal humerus with a wide zone of transition without sclerotic margins. Magnetic resonance imaging showed T1 hypointense, T2/PDFS hyperintense large well-defined expansile lytic lesion with multi-loculated cysts, and multiple blood-fluid levels involving right proximal humerus. The patient underwent an incisional biopsy which exhibited angiosarcoma of the humerus. The patient was treated with six cycles of chemotherapy with a mesna, doxorubicin, ifosfamide, and dacarbazine regimen. The patient was still under follow-up. Conclusion: Being a rare clinical entity, controversy exists in angiosarcoma of humerus regarding its etiology and recommended management protocols. Histopathology and immunohistochemistry remain the gold standard in differentiating osseous angiosarcoma from other osseous vascular tumors. The treatment protocol has to be standardized to

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Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma

Cited by 8 publications

References 11 publications

Pterygium—The Good, the Bad, and the Ugly

Pterygium—The Good, the Bad, and the Ugly

Malignant Conversion of Eyelid Capillary Hemangioma to Cutaneous Angiosarcoma

Primary Angiosarcoma of Humerus – A Case Report and Literature Review

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